| No. overall | No. in season | Main segment | Original release date | U . viewers (millions) |
| 90 | 1 | False or misleading statements by Donald Trump | February 12, 2017 (2017-02-12) | 1 |
| Main article: Trump vs. Truth Guest: Actor Thomas Kopache |
| 91 | 2 | Vladimir Putin and Russia–United States relations | February 19, 2017 (2017-02-19) | 1 |
| Guests: Singers and dancers Olivia Cipolla, Michaela Sprague, Nicole Medoro, Mishay Petronelli and Wesley Faucher |
| 92 | 3 | Affordable Care Act (Obamacare) | February 26, 2017 (2017-02-26) | 0 |
| Other segment: Immigration policy of Donald Trump |
| 93 | 4 | Tibetan sovereignty debate and Human rights in Tibet | March 5, 2017 (2017-03-05) | 1 |
| Other segment: Presidency of Donald Trump Guests: 14th Dalai Lama |
| 94 | 5 | American Health Care Act | March 12, 2017 (2017-03-12) | 1 |
| Other segments: International Women's Day, Wikileaks' March 2017 CIA disclosures Guests: Actors Thomas Kopache, Rob Corddry |
| 95 | 6 | United States federal budget | March 19, 2017 (2017-03-19) | 1 |
| Other segments: Trump Tower wiretapping allegations, La Paz traffic zebras |
| 96 | 7 | Cannabis in the United States | April 2, 2017 (2017-04-02) | 1 |
| Other segments: Trump Tower wiretapping allegations, United Kingdom invocation of Article 50 of the Treaty on European Union, La Paz traffic zebras Guest: Actor and puppeteer Noel MacNeal |
| 97 | 8 | Gerrymandering in the United States | April 9, 2017 (2017-04-09) | 1 |
| Other segments: 2017 Shayrat missile strike, Bill O'Reilly sexual harassment lawsuits Guest: Actor Thomas Kopache |
| 98 | 9 | 2017 French presidential election | April 16, 2017 (2017-04-16) | 1 |
| Other segments: Sean Spicer Hitler–Assad controversy, political positions of Donald Trump, 2017 Nangarhar airstrike |
| 99 | 10 | Ivanka Trump and Jared Kushner | April 23, 2017 (2017-04-23) | 1 |
| Other segments: 2017 North Korean missile tests, 2017 Turkish constitutional referendum Guest: Actor Gilbert Gottfried |
| 100 | 11 | Net neutrality in the United States | May 7, 2017 (2017-05-07) | 1 |
| Main article: Net Neutrality II Other segments: Eight Mile Style v New Zealand National Party, American Health Care Act of 2017 |
| 101 | 12 | Kidney dialysis and DaVita Inc. | May 14, 2017 (2017-05-14) | 1 |
| Other segments: Dismissal of James Comey, Bill English |
| 102 | 13 | Russian interference in the 2016 United States elections | May 21, 2017 (2017-05-21) | 1 |
| Main article: Stupid Watergate Other segments: Donald Trump's disclosure of classified information to Russia, Comey memos, Transportation Security Administration Guests: Sesame Street penguins (performed by actors and puppeteers Pam Arciero, Tyler Bunch, Stephanie D'Abruzzo, and John Kennedy) |
| 103 | 14 | United States withdrawal from the Paris Agreement | June 4, 2017 (2017-06-04) | 1 |
| Other segments: 2017 London Bridge attack, Russian interference in the 2016 United States elections |
| 104 | 15 | 2017 United Kingdom general election and Brexit negotiations | June 11, 2017 (2017-06-11) | 1 |
| Other segment: James Comey's testimony before Congress Guest: Lord Buckethead |
| 105 | 16 | Coal mining in the United States and Bob Murray | June 18, 2017 (2017-06-18) | 1 |
| Other segment: American Health Care Act of 2017 Guest: Actor and puppeteer Noel MacNeal Note: Within four days of airing of this episode, Bob Murray sued John Oliver for defamation over content presented in this episode. Murray eventually dropped his lawsuit two years later, which was the subject of the main segment of the November 10, 2019 episod |
| 106 | 17 | Vaccine safety | June 25, 2017 (2017-06-25) | 1 |
| Other segments: Lawsuit over coal segment from episode 105, possible existence of Trump–Comey recordings, Better Care Reconciliation Act of 2017 |
| 107 | 18 | Local news and Sinclair Broadcast Group | July 2, 2017 (2017-07-02) | 1 |
| Other segments: Donald Trump's Twitter comments about Mika Brzezinski, Trump administration's travel ban, the Hall of Presidents wax museum in Gettysburg Guests: Actors Steve Schirripa, Campbell Scott, Anna Kendrick, Michael McKean, James Cromwell, and Laura Linney |
| 108 | 19 | Alex Jones and InfoWars | July 30, 2017 (2017-07-30) | 1 |
| Other segments: Donald Trump administration's proposed transgender military ban, Anthony Scaramucci, Health Care Freedom Act of 2017 Guests: Actors Jack McBrayer, Gilbert Gottfried |
| 109 | 20 | United States Border Patrol | August 6, 2017 (2017-08-06) | 1 |
| Other segments: Presidency of Donald Trump, Stephen Miller Guests: Actor Will Arnett |
| 110 | 21 | 2017 North Korea crisis | August 13, 2017 (2017-08-13) | 1 |
| Other segment: Charlottesville car attack Guests: Musician "Weird Al" Yankovic |
| 111 | 22 | Nuclear waste | August 20, 2017 (2017-08-20) | 1 |
| Other segments: Departure of Steve Bannon, Donald Trump's response to Charlottesville |
| 112 | 23 | Pardon of Joe Arpaio | September 10, 2017 (2017-09-10) | 0 |
| Other segments: 2018 United States federal budget, rescinding of Deferred Action for Childhood Arrivals |
| 113 | 24 | Mergers and acquisitions | September 24, 2017 (2017-09-24) | 1 |
| Other segments: 2017 NFL U . national anthem protest, Tom Price and Steven Mnuchin private jet scandals |
| 114 | 25 | Forensic identification | October 1, 2017 (2017-10-01) | 1 |