| No.overall | No. inseason | Main segment | Original release date | viewers(millions) |
| 321 | 1 | DOGE and Elon Musk's influence on Trump's presidency | February 16, 2025 (2025-02-16) | 0.255 |
| Other segment: Recap of major news stories from the previous two months |
| 322 | 2 | Online content moderation, particularly for Facebook | February 23, 2025 (2025-02-23) | N/A |
| Other segments: 2025 United States federal mass layoffs and DOGE budget savings underperformanceGuests: Cecily Strong, Ronny Chieng, Peter Grosz, Tarik Davis |
| 323 | 3 | Tipping | March 2, 2025 (2025-03-02) | 0.317 |
| Other segments: The Silicon Valley Auto Show, 2025 Trump–Zelenskyy meeting, Kash Patel and Dan Bongino's leadership at the FBI |
| 324 | 4 | Immigration and Customs Enforcement detention centers | March 9, 2025 (2025-03-09) | N/A |
| Other segments: 2025 Donald Trump speech to a joint session of Congress, town hall meetings with members of the 119th United States Congress, and the Trump tariffs |
| 325 | 5 | Sports betting in the United States | March 16, 2025 (2025-03-16) | N/A |
| Other segment: Detention of Mahmoud KhalilGuests: Ben Schwartz, Adam Pally, Bobby Moynihan, Casey Wilson, Jacquis Neal |
| 326 | 6 | Axon Enterprise, use of tasers by police in America, and excited delirium | March 30, 2025 (2025-03-30) | N/A |
| Other segments: Signalgate, theft of a Paddington Bear statue, and 2025 Turkish protests |
| 327 | 7 | Discrimination against trans women in sports in the United States | April 6, 2025 (2025-04-06) | N/A |
| Other segment: The Trump tariffs |
| 328 | 8 | Tariffs in the second Trump administration | April 13, 2025 (2025-04-13) | N/A |
| Other segments: Fish doorbell, Linda McMahon mis-abbreviating Artificial Intelligence as "A1" instead of AIGuest: Mario (performing a song written for the Fish doorbell segment) |
| 329 | 9 | Robert F. Kennedy Jr. and cuts made to the Department of Health and Human Services | April 27, 2025 (2025-04-27) | N/A |
| Other segment: Death and funeral of Pope Francis and a possible papacy of Pierbattista Pizzaballa |
| 330 | 10 | Immigrants and deportations under Trump | May 4, 2025 (2025-05-04) | N/A |
| Other segments: 2025 Canadian federal election, Minor league baseball team names |
| 331 | 11 | Alliance Defending Freedom | May 11, 2025 (2025-05-11) | N/A |
| Other segments: 2025 papal conclave, Tariffs in the second Trump administration, John Kruk's color commentary |
| 332 | 12 | Freedom of the press under the second Trump administration | May 18, 2025 (2025-05-18) | N/A |
| Other segments: Eurovision Song Contest 2025, HBO Max rebranding, followup to the Minor league baseball rebranding contest from Episode 330 |
| 333 | 13 | Air traffic control in the United States | June 1, 2025 (2025-06-01) | N/A |
| Other segment: Use of pardons by President TrumpGuests: Lauren Adams, H. Jon Benjamin, Lil Rel Howery, and Keyla Monterroso Mejia as air traffic controllers |
| 334 | 14 | Med spas | June 8, 2025 (2025-06-08) | N/A |
| Other segments: TV coverage of the 2025 South Korean presidential election, Elon Musk–Donald Trump feud, Dominion Voting Systems' civil lawsuit against Mike Lindell, and Stephen Baldwin's one-man film "Heaven, How I Got Here: The Story of the Thief on the Cross"Guest: Rachel Dratch as Wanda Jo Oliver |
| 335 | 15 | Juvenile courts and youth incarceration in the United States | June 15, 2025 (2025-06-15) | N/A |
| Other segments: Ed (an escaped zebra who was returned to his owners via helicopter after his capture), and the June 2025 Los Angeles protests |
| 336 | 16 | AI slop | June 22, 2025 (2025-06-22) | N/A |
| Other segment: Iran–Israel warGuest: Michael Jones, British woodcarver and content creator |
| 337 | 17 | The One Big Beautiful Bill Act | June 29, 2025 (2025-06-29) | N/A |
| Other segments: The Democratic Primaries in the 2025 New York City mayoral election; the second followup to the Minor league baseball rebranding contest from Episode 330 Guest: Bob Costas (voice-over) |
| 338 | 18 | Gang databases | July 27, 2025 (2025-07-27) | N/A |
| Other segments: The relationship between Donald Trump and Jeffrey Epstein and the Jeffrey Epstein client list, and the debut game of the Erie Moon Mammoths (the third followup to the Minor league baseball rebranding contest from Episode 330) Guests: L.V., Bob Costas (voice-over), and people associated with Erie, Pennsylvania, or its minor league baseball team including: Laina Banic (Director of fan engagement for the team), Gregg Coleman (Team president), George Moon (Amateur scuba diver), John Oliver (President of the Erie tourist association)Note: In addition to appearing as a guest, L.V. was also profiled in the main segment |
| 339 | 19 | Deferred prosecution agreements | August 3, 2025 (2025-08-03) | N/A |
| Other segments: Product recall of the High Noon seltzer, Gaza Strip famine |
| 340 | 20 | Changes to ICE and related agencies' conduct during Trump's second term | August 10, 2025 (2025-08-10) | N/A |
| Other segments: Donald Trump's tour of the roof of the White House, Chuck Schumer's use of a persona couple (which he named "The Baileys") to make points about public policy Guests: Bobby Moynihan and Edi Patterson (as Mr. and Mrs. Bailey) |
| 341 | 21 | Make America Healthy Again, wellness influencer marketing, and Casey Means | August 17, 2025 (2025-08-17) | N/A |
| Other segments: 2025 Russia–United States Summit, Trump's federal takeover of DC police |
| 342 | 22 | Tertiary education policy of the second Trump administration | September 7, 2025 (2025-09-07) | N/A |
| Other segments: 2025 China Victory Day Parade, the State of Florida dropping mandatory vaccinations for public school students |
| 343 | 23 | Suspension of Jimmy Kimmel Live! | September 21, 2025 (2025-09-21) | N/A |
| Other segments: 2025 state visit by Donald Trump to the United Kingdom, Bernd das Brot Guest: H. Jon Benjamin (voice-over) |
| 344 | 24 | Benjamin Netanyahu | September 28, 2025 (2025-09-28) | N/A |
| Other segments: 2025 Donald Trump speech at the United Nations, Indictment of James Comey |
| 345 | 25 | The U.S. Presidential library system | October 5, 2025 (2025-10-05) | N/A |