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Liquid breathing

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Liquid breathing

Liquid breathing is a form of respiration in which a normally air-breathing organism breathes an oxygen-rich liquid which is capable of CO2 gas exchange (such as a perfluorocarbon). The liquid involved requires certain physical properties, such as respiratory gas solubility, density, viscosity, vapor pressure and lipid solubility, which some perfluorochemicals (PFCs) have. Thus, it is critical to choose the appropriate PFC for a specific biomedical application, such as liquid ventilation, drug delivery or blood substitutes. The physical properties of PFC liquids vary substantially; however, the one common property is their high solubility for respiratory gases. In fact, these liquids carry more oxygen and carbon dioxide than blood. In theory, liquid breathing could assist in the treatment of patients with severe pulmonary or cardiac trauma, especially in pediatric cases. Liquid breathing has also been proposed for use in deep diving and space travel. Despite some recent advances in liquid ventilation, a standard mode of application has not yet been established.

Infobox

MeSH
D021061

Tables

Physicochemical properties (37 °C at 1 atm) of 18 perfluorochemical liquids used for biomedical applications. This table characterizes the most significant physical properties related to systemic physiology and their range of properties. · Approaches
Oxygen
Oxygen
Gas solubility
Oxygen
Col 2
33–66 mL / 100 mL PFC
Carbon dioxide
Carbon dioxide
Gas solubility
Carbon dioxide
Col 2
140–166 mL / 100 mL PFC
Vapor pressure
Vapor pressure
Gas solubility
Vapor pressure
Col 2
0.2–400 torr
Density
Density
Gas solubility
Density
Col 2
1.58–2.1 g/mL
Viscosity
Viscosity
Gas solubility
Viscosity
Col 2
1–8.0 cSt
Gas solubility
Oxygen
33–66 mL / 100 mL PFC
Carbon dioxide
140–166 mL / 100 mL PFC
Vapor pressure
torr
Density
1.58–2.1 g/mL
Viscosity
cSt

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