| Year | Title | Role | Notes |
| 1980 | Shirley | Gloria | Episode: "Teddy Roosevelt Slept Here" |
| 1980 | Reunion | Anne Samoorian | Television film |
| 1980 | Rape and Marriage: The Rideout Case | Greta Rideout | Television film |
| 1980–1981 | Secrets of Midland Heights | Lisa Rogers | 10 episodes |
| 1982 | King's Crossing | Lauren Hollister | 10 episodes |
| 1982 | Country Gold | Josie Greenwood | Television film |
| 1984 | Hill Street Blues | Sandy Valpariso | 4 episodes |
| 1985 | Secret Weapons | Elena Koslov | Television film |
| 1986 | Murder, She Wrote | Carol McDermott | Episode: "Menace, Anyone?" |
| 1986 | Club Med | Kate | Television film |
| 1987–1989 | Beauty and the Beast | Catherine Chandler | 46 episodes |
| 1988 | Go Toward the Light | Claire Madison | Television film |
| 1991 | Saturday Night Live | Host | Episode: "Linda Hamilton/Mariah Carey" |
| 1995 | A Mother's Prayer | Rosemary Holstrom | Television film |
| 1997 | Frasier | Laura | Episode: "Odd Man Out" |
| 1998 | On the Line | Det. Jean Martin | Television film |
| 1998 | Rescuers: Stories of Courage – Two Couples | Marie Taquet | Television film |
| 1998 | Point Last Seen | Rachel Harrison | Television film |
| 1998 | The Color of Courage | Anna Sipes | Television film |
| 1998 | The New Batman Adventures | Susan | Voice, episode: "Chemistry" |
| 1998–1999 | Hercules | Nemesis | Voice, 2 episodes |
| 1999 | Batman Beyond | Dr. Stephanie Lake | Voice, episode: "Meltdown" |
| 2000 | Sex & Mrs. X | Joanna Scott | Television film |
| 2000 | Buzz Lightyear of Star Command | Dr. Furbanna | Voice, 3 episodes |
| 2001 | Bailey's Mistake | Liz Donovan | Television film |
| 2001 | A Girl Thing | Rachel Logan | Television film |
| 2002 | Silent Night | Elisabeth Vincken | Television film |
| 2003 | Wholey Moses | Valerie | Short film |
| 2004 | Jonah | June | Short film |
| 2005 | According to Jim | Melissa Evans | Episode: "Lean on Me" |
| 2006 | Thief | Roselyn Moore | 2 episodes |
| 2006 | Home by Christmas | Julie Bedford | Television film |
| 2008–2009 | The Line | Carol | 11 episodes |
| 2010 | Weeds | Linda | 3 episodes |
| 2010–2012 | Chuck | Mary Elizabeth Bartowski | 12 episodes |
| 2013 | Bad Behavior | Margaret | Television film |
| 2013 | Lost Girl | Acacia | 2 episodes |
| 2013 | Air Force One Is Down | United States President Harriet Rowntree | Television miniseries |
| 2014 | Bermuda Tentacles | Admiral Hansen | Television film |
| 2014–2015 | Defiance | Pilar McCawley | 6 episodes |
| 2017 | Shoot Me Nicely | Layla | Short film |
| 2020 | Big City Greens | Librarian | Voice, episode: "Quiet Please" |
| 2021–2025 | Resident Alien | General McCallister | Recurring role; 21 episodes |
| 2021 | Claws | Eve | 6 episodes |
| 2024 | Solar Opposites | Narrator | Episode: “An Earth Shatteringly Romantic Solar Valentine's Day Opposites Special” |
| 2025 | Stranger Things | Major General Dr. Kay | Season 5 |
