| No. | Result | Record | Opponent | Type | Round(s), time | Date | Location | Notes |
| 75 | Win | 69–6 | Eric Esch | UD | 10 | Jul 27, 2002 | Scope, Norfolk, Virginia, U.S. | |
| 74 | Win | 68–6 | Mike Weaver | TKO | 6 (10), 0:45 | Nov 17, 2000 | Coast Coliseum, Biloxi, Mississippi, U.S. | |
| 73 | Win | 67–6 | James Smith | TKO | 8 (10), 2:00 | Jun 18, 1999 | Crown Coliseum, Fayetteville, North Carolina, U.S. | |
| 72 | Win | 66–6 | Maurice Harris | SD | 10 | Jul 29, 1997 | The Theater at Madison Square Garden, New York City, New York, U.S. | |
| 71 | Loss | 65–6 | Brian Nielsen | SD | 12 | Jan 24, 1997 | Brøndby Hall, Copenhagen, Denmark | For IBO heavyweight title |
| 70 | Win | 65–5 | Anthony Willis | KO | 8 (10), 1:13 | Jun 16, 1996 | Casino Magic, Bay St. Louis, Mississippi, U.S. | |
| 69 | Win | 64–5 | Quinn Navarre | UD | 10 | Apr 16, 1996 | Casino Magic, Bay St. Louis, Mississippi, U.S. | |
| 68 | Win | 63–5 | Curtis Sheppard | KO | 4 (10), 2:41 | Jan 9, 1996 | Casino Magic, Bay St. Louis, Mississippi, U.S. | |
| 67 | Win | 62–5 | Ed Donaldson | UD | 10 | Sep 19, 1995 | Casino Magic, Bay St. Louis, Mississippi, U.S. | |
| 66 | Loss | 61–5 | Oliver McCall | UD | 12 | Apr 8, 1995 | Caesars Palace, Paradise, Nevada, U.S. | For WBC heavyweight title |
| 65 | Win | 61–4 | Jesse Ferguson | UD | 10 | Sep 8, 1994 | Mystic Lake Casino Hotel, Shakopee, Minnesota, U.S. | |
| 64 | Win | 60–4 | Garing Lane | UD | 10 | Mar 8, 1994 | Foxwoods Resort Casino, Ledyard, Connecticut, U.S. | |
| 63 | Win | 59–4 | José Ribalta | UD | 10 | Sep 28, 1993 | Casino Magic, Bay St. Louis, Mississippi, U.S. | |
| 62 | Win | 58–4 | Paul Poirier | RTD | 6 (10), 3:00 | May 18, 1993 | Casino Magic, Bay St. Louis, Mississippi, U.S. | |
| 61 | Win | 57–4 | Ken Lakusta | RTD | 7 (10), 3:00 | Apr 13, 1993 | Casino Magic, Bay St. Louis, Mississippi, U.S. | |
| 60 | Win | 56–4 | Rocky Pepeli | RTD | 4 (10), 3:00 | Mar 9, 1993 | Casino Magic, Bay St. Louis, Mississippi, U.S. | |
| 59 | Win | 55–4 | Everett Martin | UD | 10 | Jan 5, 1993 | Coast Coliseum, Biloxi, Mississippi, U.S. | |
| 58 | Loss | 54–4 | Evander Holyfield | UD | 12 | Jun 19, 1992 | Caesars Palace, Paradise, Nevada, U.S. | For WBA, WBC, and IBF heavyweight titles |
| 57 | Win | 54–3 | Ray Mercer | UD | 12 | Feb 7, 1992 | Convention Hall, Atlantic City, New Jersey, U.S. | |
| 56 | Win | 53–3 | Jamie Howe | TKO | 1 (10), 1:57 | Nov 12, 1991 | Coliseum, Jacksonville, Florida, U.S. | |
| 55 | Win | 52–3 | Art Card | UD | 10 | Sep 17, 1991 | Marriott's World Center, Orlando, Florida, U.S. | |
| 54 | Win | 51–3 | Michael Greer | KO | 4 (10), 1:18 | Aug 24, 1991 | Neal S. Blaisdell Arena, Honolulu, Hawaii, U.S. | |
| 53 | Win | 50–3 | Eddie Gonzales | UD | 10 | Aug 13, 1991 | Hyatt Regency, Tampa, Florida, U.S. | |
| 52 | Win | 49–3 | Tim Anderson | TKO | 1 (10), 2:03 | Apr 7, 1991 | The Diplomat, Hollywood, Florida, U.S. | |
| 51 | Loss | 48–3 | Mike Tyson | TKO | 4 (12), 2:55 | Jan 22, 1988 | Convention Hall, Atlantic City, New Jersey, U.S. | For WBA, WBC, and IBF heavyweight titles |
| 50 | Loss | 48–2 | Michael Spinks | SD | 15 | Apr 19, 1986 | Las Vegas Hilton, Winchester, Nevada, U.S. | For IBF and The Ring heavyweight titles |
| 49 | Loss | 48–1 | Michael Spinks | UD | 15 | Sep 21, 1985 | Riviera, Winchester, Nevada, U.S. | Lost IBF and The Ring heavyweight titles |
| 48 | Win | 48–0 | Carl Williams | UD | 15 | May 20, 1985 | Lawlor Events Center, Reno, Nevada, U.S. | Retained IBF and The Ring heavyweight titles |
| 47 | Win | 47–0 | David Bey | TKO | 10 (15), 2:58 | Mar 15, 1985 | Riviera, Winchester, Nevada, U.S. | Retained IBF and The Ring heavyweight titles |
| 46 | Win | 46–0 | James Smith | TKO | 12 (15), 2:10 | Nov 9, 1984 | Riviera, Winchester, Nevada, U.S. | Retained IBF and The Ring heavyweight titles |
| 45 | Win | 45–0 | Marvis Frazier | TKO | 1 (12), 2:57 | Nov 25, 1983 | Caesars Palace, Paradise, Nevada, U.S. | Retained The Ring heavyweight title |
| 44 | Win | 44–0 | Scott Frank | TKO | 5 (12), 1:28 | Sep 10, 1983 | Broadway by the Bay Theater, Atlantic City, New Jersey, U.S. | Retained WBC and The Ring heavyweight titles |
| 43 | Win | 43–0 | Tim Witherspoon | SD | 12 | May 20, 1983 | Dunes, Paradise, Nevada, U.S. | Retained WBC and The Ring heavyweight titles |
| 42 | Win | 42–0 | Lucien Rodriguez | UD | 12 | Mar 27, 1983 | Watres Armory, Scranton, Pennsylvania, U.S. | Retained WBC and The Ring heavyweight titles |
| 41 | Win | 41–0 | Randall Cobb | UD | 15 | Nov 26, 1982 | Astrodome, Houston, Texas, U.S. | Retained WBC and The Ring heavyweight titles |
| 40 | Win | 40–0 | Gerry Cooney | TKO | 13 (15), 2:52 | Jun 11, 1982 | Caesars Palace, Paradise, Nevada, U.S. | Retained WBC and The Ring heavyweight titles |
| 39 | Win | 39–0 | Renaldo Snipes | TKO | 11 (15), 1:05 | Nov 6, 1981 | Civic Arena, Pittsburgh, Pennsylvania, U.S. | Retained WBC and The Ring heavyweight titles |
| 38 | Win | 38–0 | Leon Spinks | TKO | 3 (15), 2:34 | Jun 12, 1981 | Joe Louis Arena, Detroit, Michigan, U.S. | Retained WBC and The Ring heavyweight titles |
| 37 | Win | 37–0 | Trevor Berbick | UD | 15 | Apr 11, 1981 | Caesars Palace, Paradise, Nevada, U.S. | Retained WBC and The Ring heavyweight titles |
| 36 | Win | 36–0 | Muhammad Ali | RTD | 10 (15), 3:00 | Oct 2, 1980 | Caesars Palace, Paradise, Nevada, U.S. | Retained WBC and The Ring heavyweight titles |
| 35 | Win | 35–0 | Scott LeDoux | TKO | 7 (15), 2:05 | Jul 7, 1980 | Metropolitan Sports Center, Bloomington, Minnesota, U.S. | Retained WBC and The Ring heavyweight titles |
| 34 | Win | 34–0 | Leroy Jones | TKO | 8 (15), 2:56 | Mar 31, 1980 | Caesars Palace, Paradise, Nevada, U.S. | Retained WBC heavyweight title |
| 33 | Win | 33–0 | Lorenzo Zanon | KO | 6 (15), 2:39 | Feb 3, 1980 | Caesars Palace, Paradise, Nevada, U.S. | Retained WBC heavyweight title |
| 32 | Win | 32–0 | Earnie Shavers | TKO | 11 (15), 2:00 | Sep 28, 1979 | Caesars Palace, Paradise, Nevada, U.S. | Retained WBC heavyweight title |
| 31 | Win | 31–0 | Mike Weaver | TKO | 12 (15), 0:44 | Jun 22, 1979 | Madison Square Garden, New York City, New York, U.S. | Retained WBC heavyweight title |
| 30 | Win | 30–0 | Ossie Ocasio | TKO | 7 (15), 2:38 | Mar 23, 1979 | Hilton, Winchester, Nevada, U.S. | Retained WBC heavyweight title |
| 29 | Win | 29–0 | Alfredo Evangelista | KO | 7 (15), 2:14 | Nov 10, 1978 | Caesars Palace, Paradise, Nevada, U.S. | Retained WBC heavyweight title |
| 28 | Win | 28–0 | Ken Norton | SD | 15 | Jun 9, 1978 | Caesars Palace, Paradise, Nevada, U.S. | Won WBC heavyweight title |
| 27 | Win | 27–0 | Earnie Shavers | UD | 12 | Mar 25, 1978 | Caesars Palace, Paradise, Nevada, U.S. | |