| Res. | Record | Opponent | Method | Event | Date | Round | Time | Location | Notes |
| Win | 29–0 | Justin Gaethje | Technical Submission (triangle choke) | UFC 254 | 24 October 2020 | 2 | 1:34 | Abu Dhabi, United Arab Emirates | Defended and unified the UFC Lightweight Championship. Performance of the Night. Later vacated title after announcing retirement. |
| Win | 28–0 | Dustin Poirier | Submission (rear-naked choke) | UFC 242 | 7 September 2019 | 3 | 2:06 | Abu Dhabi, United Arab Emirates | Defended and unified the UFC Lightweight Championship. Performance of the Night. |
| Win | 27–0 | Conor McGregor | Submission (neck crank) | UFC 229 | 6 October 2018 | 4 | 3:03 | Las Vegas, Nevada, United States | Defended the UFC Lightweight Championship. |
| Win | 26–0 | Al Iaquinta | Decision (unanimous) | UFC 223 | 7 April 2018 | 5 | 5:00 | Brooklyn, New York, United States | Won the vacant UFC Lightweight Championship. |
| Win | 25–0 | Edson Barboza | Decision (unanimous) | UFC 219 | 30 December 2017 | 3 | 5:00 | Las Vegas, Nevada, United States | Performance of the Night. |
| Win | 24–0 | Michael Johnson | Submission (kimura) | UFC 205 | 12 November 2016 | 3 | 2:31 | New York City, New York, United States | |
| Win | 23–0 | Darrell Horcher | TKO (punches) | UFC on Fox: Teixeira vs. Evans | 16 April 2016 | 2 | 3:38 | Tampa, Florida, United States | Catchweight (160 lb) bout. |
| Win | 22–0 | Rafael dos Anjos | Decision (unanimous) | UFC on Fox: Werdum vs. Browne | 19 April 2014 | 3 | 5:00 | Orlando, Florida, United States | |
| Win | 21–0 | Pat Healy | Decision (unanimous) | UFC 165 | 21 September 2013 | 3 | 5:00 | Toronto, Ontario, Canada | |
| Win | 20–0 | Abel Trujillo | Decision (unanimous) | UFC 160 | 25 May 2013 | 3 | 5:00 | Las Vegas, Nevada, United States | Catchweight (158.5 lb) bout; Nurmagomedov missed weight. |
| Win | 19–0 | Thiago Tavares | KO (punches and elbows) | UFC on FX: Belfort vs. Bisping | 19 January 2013 | 1 | 1:55 | São Paulo, Brazil | Tavares tested positive for drostanolone. |
| Win | 18–0 | Gleison Tibau | Decision (unanimous) | UFC 148 | 7 July 2012 | 3 | 5:00 | Las Vegas, Nevada, United States | |
| Win | 17–0 | Kamal Shalorus | Submission (rear-naked choke) | UFC on FX: Guillard vs. Miller | 20 January 2012 | 3 | 2:08 | Nashville, Tennessee, United States | Return to Lightweight. |
| Win | 16–0 | Arymarcel Santos | TKO (punches) | ProFC 36 | 22 October 2011 | 1 | 3:33 | Khasavyurt, Russia | |
| Win | 15–0 | Vadim Sandulskiy | Submission (triangle choke) | ProFC / GM Fight: Ukraine Cup 3 | 15 September 2011 | 1 | 3:01 | Odesa, Ukraine | |
| Win | 14–0 | Khamiz Mamedov | Submission (triangle choke) | ProFC 30 | 5 August 2011 | 1 | 3:15 | Rostov-on-Don, Russia | |
| Win | 13–0 | Kadzhik Abadzhyan | Submission (triangle choke) | ProFC 29: Union Nation Cup Final | 2 July 2011 | 1 | 4:28 | Rostov-on-Don, Russia | |
| Win | 12–0 | Ashot Shaginyan | KO (punches) | ProFC 28: Union Nation Cup 15 | 5 May 2011 | 1 | 2:18 | Rostov-on-Don, Russia | |
| Win | 11–0 | Said Khalilov | Submission (kimura) | ProFC 26: Union Nation Cup 14 | 9 April 2011 | 1 | 3:16 | Rostov-on-Don, Russia | |
| Win | 10–0 | Alexander Agafonov | TKO (corner stoppage) | M-1 Selection Ukraine 2010: The Finals | 12 February 2011 | 2 | 5:00 | Kyiv, Ukraine | |
| Win | 9–0 | Vitaliy Ostroskiy | TKO (punches) | M-1 Selection Ukraine 2010: Clash of the Titans | 18 September 2010 | 1 | 4:06 | Kyiv, Ukraine | |
| Win | 8–0 | Ali Bagov | Decision (unanimous) | Golden Fist of Russia 1 | 10 June 2010 | 2 | 5:00 | Moscow, Russia | |
| Win | 7–0 | Shahbulat Shamhalaev | Submission (armbar) | M-1 Challenge: 2009 Selections 9 | 3 November 2009 | 1 | 4:36 | Saint Petersburg, Russia | Lightweight bout. |
| Win | 6–0 | Eldar Eldarov | TKO (punches) | Tsumada FC 3 | 8 August 2009 | 2 | 2:44 | Agvali, Russia | Won the Tsumada FC Welterweight Tournament. |
| Win | 5–0 | Said Akhmed | TKO (punches) | 1 | 2:05 | Welterweight debut. Tsumada FC Welterweight Tournament Semifinal. |
| Win | 4–0 | Shamil Abdulkerimov | Decision (unanimous) | Atrium Pankration Cup 2008 | 11 October 2008 | 2 | 5:00 | Moscow, Russia | Won the Atrium Pankration Cup Lightweight Tournament. |
| Win | 3–0 | Ramazan Kurbanismailov | Decision (unanimous) | 2 | 5:00 | Atrium Pankration Cup Lightweight Tournament Semifinal. |
| Win | 2–0 | Magomed Magomedov | Decision (unanimous) | 2 | 5:00 | Atrium Pankration Cup Lightweight Tournament Quarterfinal. |
| Win | 1–0 | Vusal Bayramov | Submission (triangle choke) | CSFU: Champions League | 13 September 2008 | 1 | 2:20 | Poltava, Ukraine | Lightweight debut. |