| Year | Title | Role | Notes |
| 1994–1999, 2002,2005, 2019–2020 | All That | Various roles | Main role (Seasons 1-5); guest role (Season 7); guest role (Seasons 10-11); Executive producer (Season 11) |
| 1996–1998 | The Steve Harvey Show | Junior | 4 episodes |
| 1996–2000 | Kenan & Kel | Kenan Rockmore | Main role |
| 1997 | Sister, Sister | Trevor | Episode: "Inherit the Twin" |
| 1998 | Sabrina, the Teenage Witch | Kenan Rockmore | Episode: "Sabrina's Choice" |
| 1999 | Oh Yeah! Cartoons | Host | |
| 1999 | The Amanda Show | Himself | Episode: "Episode 1" |
| Cousin Skeeter | Kenan Rockmore | Episodes: "Hoo, I'm Wild Wild West" (Parts 1 & 2) |
| 2000 | The Parkers | Damon | Episode: "Trading Places" |
| 2001 | Untitled Sisqo Project | | NBC television sitcom pilot |
| 2001 | Felicity | DeForrest Ingram | 4 episodes |
| 2002 | Off Centre | MC French | 2 episodes |
| 2003 | Clifford the Big Red Dog | Hamburger | Voice; episode: "Food for Thought/Friends Forever" |
| 2003–present | Saturday Night Live | Himself/Various roles | Featured player (Seasons 29–30); Repertory player (Season 31–present) |
| 2005, 2018 | Wild 'n Out | Himself | 2 episodes |
| 2005 | Rugrats | Magic Mirror | Voice; Direct-to-video episode: "Tales from the Crib: Snow White" |
| 2007 | Crank Yankers | Mark Thomas | Episode: "4.1" |
| 2008 | The Mighty B! | Rocky Rhodes | Voice; 5 episodes |
| 2009 | Psych | Joon | Episode: "High Top Fade-Out" |
| Sit Down, Shut Up | Sue Sezno | Voice: 13 episodes |
| 2011 | iCarly | Himself | Episode: "iParty with Victorious" |
| The '90s Are All That | Host | |
| 2013 | Wonder Pets! | Lion | Voice; episode: "In the Land of Oz" |
| Martha Speaks | Stanley | Voice; episode: "Stanley Saves the Day" |
| 2013–15 | The Awesomes | Austin "Impresario" Sullivan | Voice |
| 2015 | Randy Cunningham: 9th Grade Ninja | Socko | Voice; episode: "Rorg: A Hero of a Past" |
| The Tonight Show Starring Jimmy Fallon | Lester Oakes | Episode: "James Spader/Andrew Rannells/Brian Regan" |
| 2015–17 | Nature Cat | Ronald | Voice, season 1 only |
| 2016 | Maya & Marty | Various roles | Main role |
| 2016, 2019 | Unbreakable Kimmy Schmidt | Roland | 2 episodes |
| 2017–19 | Match Game | Himself/Panelist | 4 episodes |
| 2018 | Double Dare | Himself | Contestant; episode: "Team Kel vs. Team Kenan" |
| Studio C | Himself, various roles | |
| 2019 | The Masked Singer | Himself | Guest judge; episodes 8, 9 |
| Scooby-Doo and Guess Who? | Voice; episode: "Quit Clowning!" |
| Bring the Funny | Judge |
| 2020 | America's Got Talent | Guest judge | Season 15, two episodes1 |
| 2020–22 | Trolls: TrollsTopia | Tiny Diamond | Voice |
| 2021–22 | Kenan | Kenan Williams | Main role and executive producer |
| 2021 | 2021 Kids' Choice Awards | Himself | Host |
| Trolls: Holiday in Harmony | Tiny Diamond | Voice |
| 47th People's Choice Awards | Himself | Host |
| Jonas Brothers Family Roast |
| Bless the Harts | Travis | Voice; 6 episodes |
| 2022 | Fraggle Rock: Back to the Rock | Jack Hammer Doozer | Voice; episode: "Wembley the Spokesfraggle" |
| The Boys Presents: Diabolical | Mo-Slo's Dad | Voice; episode: "An Animated Short Where Pissed-Off Supes Kill Their Parents" |
| The Kids in the Hall | Ron | Episode 3 |
| That Damn Michael Che | Himself | Episode: "Join the Club" |
| Archer | The Broker (voice) | Episode: "Saturday" |
