| Year | Title | Role | Notes |
| 1985 | The $25,000 Pyramid | Herself (contestant) | Celebrity Guests: Constance McCashin & LeVar Burton |
| Walls of Glass | | |
| 1991 | The Kathy & Mo Show: Parallel Lives | Herself | Television special; also writerCableACE Award for Performance in a Comedy Special (shared with Mo Gaffney) (1993)Nominated – CableACE Award for Writing an Entertainment Special (shared with Mo Gaffney) (1993) |
| 1994 | In Search of Dr. Seuss | Kathy Lane | Television movie |
| Ellen | Theresa / Lorna Irons / Woman in Gay Bar | 3 episodes: "So Funny" (Season 2) / "Go Girlz" (Season 3) / "The Puppy Episode, Part 2" (Season 4) |
| She TV | — | Also writer (1 episode) |
| 1995 | The Kathy & Mo Show: The Dark Side | Herself | Television special; also writerCableACE Award for Comedy Special (shared with Mo Gaffney, Paula Mazur & Dean Parisot) (1995)CableACE Award for Performance in a Comedy Special (shared with Mo Gaffney) (1995) |
| 1996 | Adventures from the Book of Virtues | The Old Woman (voice) | Episode: "Self-Discipline" |
| Chicago Hope | Dr. Barbara "Bix" Konstadt | Recurring role; 3 episodesNominated – Viewers for Quality Television Award for Best Recurring Player (1996) |
| 1997 | Early Edition | Psychic | Episode: "Psychic" |
| Shantay | Toyota Carter | Short |
| 1997, 1999 | Hey Arnold! | Madame Blanche (voice) | 2 episodes |
| 1997–2000 | Veronica's Closet | Olive Massery | 67 episodesOFTA Television Award for Best Supporting Actress in a Series (1998)OFTA Television Award for Best Supporting Actress in a Comedy Series (1998) |
| 1997–2010, 2025–present | King of the Hill | Peggy Hill (voice) | 269 episodesAnnie Award for Outstanding Individual Achievement for Voice Acting by a Female Performer in an Animated Television Production (2001)OFTA Television Award for Best Voice-Over Performance (2001)Nominated – Annie Award for Outstanding Individual Achievement for Voice Acting by a Female Performer in an Animated Television Production (1998)Nominated – OFTA Television Award for Best Voice-Over Performance (1998, 2004, 2005) |
| 1998–1999 | Hercules | Thespis the Muse (voice) | 2 episodes |
| 1998–2000 | Pepper Ann | Coach Doogan / Margot LaSandre / Additional voices | 5 episodes |
| 1999 | The Wild Thornberrys | Ostrich / Sand Grouse (voices) | Episode: "Have Yourself a Thornberry Little Christmas" |
| The Sissy Duckling | Mother Duck (voice) | Television film |
| CinderElmo | Stepmother | Television movie |
| 2000 | If These Walls Could Talk 2 | Doctor | Television movie; segment: "2000" |
| Leaving Peoria | Dr. Beatrice Albright | Short |
| 2000–2003 | Little Bill | Mrs. Judith Shapiro (voice) | 3 episodes; succeeded Madeline Kahn, the original voice of Mrs. Shapiro, shortly after her death in 1999. |
| 2001–2003 | Oswald | Bingette Bunny (voice) | 4 episodes |
| 2001 | The Legend of Tarzan | Dania (voice) | Episode: "Tarzan and the Rift" |
| 2002 | The Scream Team | Mariah | Television movie |
| 2003 | The Mummy | Calliope / Aglaophone (voices) | Episode: "The Enemy of My Enemy" |
| Stuart Little | Margalo (voice) | Episode: "The Meatloaf Bandit" |
| Ozzy & Drix | Loretta Epstein (voice) | Episode: "The Dream Factory" |
| The Making of King of the Hill | Herself | Television documentary |
| 2004 | Higglytown Heroes | Photographer Hero (voice) | Episode: "The Legend of Higgsquatch" |
| Rocket Power | Patsy (voice) | Episode: "Sammy's Fortune" |
| 2005 | Wayside | Mrs. Peri Jewls (voice) | Television movie |
| Getting Played | Dr. Heidi Z. Klemmer |
| Balto III: Wings of Change | Dipsy (voice) | Video |
| 2006 | Scooby-Doo! Pirates Ahoy! | Sunny St. Cloud (voice) |
| Tom and Jerry: Shiver Me Whiskers | Blue Parrot Betty (voice) |
| Rugrats | Goosey (voice) | Direct-to-DVD episode: "Tales from the Crib: Three Jacks and a Beanstalk" |
| That's So Raven | Lora Stelladora | Episode: "The Dress Is Always Greener" |
| 2006–2007 | Numb3rs | Dr. Mildred Finch | 9 episodes |
| 2007 | The Suite Life of Zack & Cody | principal Mrs. Militich | Episode: "First Day of High School" |
| 2008 | Tinker Bell | Minister of Summer (voice) | Video |
| 2009 | Drop Dead Diva | Claire Porter | Episode: "The Magic Bullet" |
| Desperate Housewives | Detective Denise Lapera | Episode: "Careful the Things You Say" |
| 2010 | Ugly Betty | Dr. Jayne Frankel | Episode: "Million Dollar Smile" |
| RuPaul's Drag Race | Herself (Guest Judge) | Episode: "Country Queens" |
| 2011 | Mr. Sunshine | Myrna | Episode: "Employee of the Year" |
| Five | Rocky | Television movie |
| Deck the Halls | Alvirah Meehan | |
| 2011–2012 | Make It or Break It | Sheila / Sheila Baboyon / Kelly's Mom | 5 episodes |
