| Organizations | Year | Category | Work | Result | Ref. |
| African-American Film Critics Association | 2022 | Best Ensemble | Glass Onion: A Knives Out Mystery | Won | |
| Astra TV Awards | 2023 | Best Actress in a Limited Series or Streaming Movie | Tiny Beautiful Things | Nominated | |
| 2025 | Best Actress in a Comedy Series | Agatha All Along | Nominated | |
| Best Cast Ensemble in a Streaming Comedy Series | Nominated |
| The Studio | Nominated |
| Austin Film Critics Association | 2022 | Best Ensemble | Glass Onion: A Knives Out Mystery | Nominated | |
| Capri Hollywood International Film Festival | 2022 | Best Ensemble Cast | Won | |
| CinemaCon | 2016 | Female Stars of the Year | Bad Moms | Won | |
| Critics' Choice Movie Awards | 2022 | Best Acting Ensemble | Glass Onion: A Knives Out Mystery | Won | |
| Critics' Choice Super Awards | 2022 | Best Actress in a Superhero Series | WandaVision | Nominated | |
| Best Villain in a Series | Won |
| 2025 | Best Actress in a Superhero Series, Limited Series or TV Movie | Agatha All Along | Nominated | |
| Best Actress in a Sci-Fi / Fantasy Series, Limited Series or TV Movie | Nominated |
| Critics' Choice Television Awards | 2012 | Best Guest Performer in a Comedy Series | Parks and Recreation | Nominated | |
| 2021 | Best Supporting Actress in a Miniseries or TV Movie | WandaVision | Nominated | |
| Detroit Film Critics Society | 2008 | Best Ensemble | Revolutionary Road | Nominated | |
| Dorian Awards | 2021 | Best Supporting TV Performance | WandaVision | Won | |
| Best TV Musical Performance | Won |
| Wilde Wit of the Year | —.mw- N/a | Nominated |
| 2025 | Best TV Performance — Comedy | Agatha All Along | Nominated | |
| Best TV Musical Performance | Nominated |
| Georgia Film Critics Association | 2022 | Best Ensemble | Glass Onion: A Knives Out Story | Won | |
| Gold Derby Awards | 2012 | Comedy Guest Actress | Parks and Recreation | Nominated | |
| 2019 | Comedy Guest Actress of the Decade | Parks and Recreation | Nominated | |
| 2021 | Movie/Limited Series Supporting Actress | WandaVision | Won | |
| 2022 | Ensemble Cast | Glass Onion: A Knives Out Mystery | Won | |
| 2025 | Comedy Actress | Agatha All Along | Won | |
| Comedy Supporting Actress | The Studio | Nominated |
| Performer of the Year | Agatha All Along / The Studio | Won |
| Golden Globe Awards | 2024 | Best Actress – Television Series Musical or Comedy | Agatha All Along | Nominated | |
| Gotham Awards | 2013 | Breakthrough Actor | Afternoon Delight | Nominated | |
| 2018 | Best Actress | Private Life | Nominated | |
| HCA Awards | 2022 | Best Cast Ensemble | Glass Onion: A Knives Out Mystery | Nominated | |
| HCA TV Awards | 2021 | Best Supporting Actress in a Limited Series, or Television Movie | WandaVision | Won | |
| Houston Film Critics Society | 2022 | Best Ensemble Cast | Glass Onion: A Knives Out Mystery | Nominated | |
| Human Rights Campaign | 2016 | Ally for Equality Award | —N/a | Won | |
| 2024 | Ally for Equality Award | —N/a | Won | |
| IMDb STARmeter Awards | 2025 | Fan Favorite Ensemble | The Studio | Won | |
| Independent Spirit Awards | 2024 | Best Lead Performance in a New Scripted Series | Agatha All Along | Nominated | |
| International Online Cinema Awards | 2015 | Best Ensemble in a Comedy Series | Transparent | Nominated | |
| 2018 | Best Supporting Actress in a Comedy Series | Nominated | |
| Best Ensemble in a Comedy Series | Nominated |
| 2021 | Best Supporting Actress in a Comedy Series | WandaVision | Nominated | |
| Miami International Film Festival | 2022 | Ensemble Award | Glass Onion: A Knives Out Mystery | Won | |
| MTV Movie & TV Awards | 2021 | Best Villain | WandaVision | Won | |
| Best Fight (shared with Elizabeth Olsen) | Won |
| Music Supervisors Guild Awards | 2025 | Best Song Written and/or Recorded for Television | Agatha All Along | Won | |
| New York Film Critics Online Awards | 2022 | Best Ensemble Cast | Glass Onion: A Knives Out Mystery | Won | |
| Online Film & Television Awards | 2018 | Best Supporting Actress in a Limited Series or TV Movie | Transparent | Nominated | |