| No. | Result | Record | Opponent | Type | Round, time | Date | Location | Notes |
| 63 | Loss | 54–7–1 (1) | Jake Paul | UD | 10 | 28 Jun 2025 | Honda Center, Anaheim, California, U.S. | |
| 62 | Win | 54–6–1 (1) | Uriah Hall | UD | 6 | 20 Jul 2024 | Amalie Arena, Tampa, Florida, U.S. | |
| 61 | Win | 53–6–1 (1) | David Zegarra | UD | 10 | 18 Dec 2021 | Palenque de la Feria Ganadera, Culiacan, Mexico | |
| 60 | Loss | 52–6–1 (1) | Anderson Silva | SD | 8 | 19 Jun 2021 | Estadio Jalisco, Guadalajara, Mexico | |
| 59 | Win | 52–5–1 (1) | Jeyson Minda | TKO | 4 (10), 2:55 | 27 Nov 2020 | Parque Revolucion, Culiacán, Mexico | |
| 58 | Loss | 51–5–1 (1) | Mario Abel Cazares | TD | 6 (10), 0:41 | 25 Sep 2020 | Grand Hotel, Tijuana, Mexico | |
| 57 | Loss | 51–4–1 (1) | Daniel Jacobs | RTD | 5 (12), 3:00 | 20 Dec 2019 | Talking Stick Resort Arena, Phoenix, Arizona, U.S. | |
| 56 | Win | 51–3–1 (1) | Evert Bravo | KO | 1 (10), 1:22 | 10 Aug 2019 | Salon Diamante Premier, San Juan de los Lagos, Mexico | |
| 55 | Loss | 50–3–1 (1) | Canelo Álvarez | UD | 12 | 6 May 2017 | T-Mobile Arena, Paradise, Nevada, U.S. | |
| 54 | Win | 50–2–1 (1) | Dominik Britsch | UD | 10 | 10 Dec 2016 | Monterrey Arena, Monterrey, Mexico | |
| 53 | Win | 49–2–1 (1) | Marcos Reyes | UD | 10 | 18 Jul 2015 | Don Haskins Center, El Paso, Texas, U.S. | |
| 52 | Loss | 48–2–1 (1) | Andrzej Fonfara | RTD | 9 (12), 3:00 | 18 Apr 2015 | StubHub Center, Carson, California, U.S. | For vacant WBC International light heavyweight title |
| 51 | Win | 48–1–1 (1) | Brian Vera | UD | 12 | 1 Mar 2014 | Alamodome, San Antonio, Texas, U.S. | Won vacant WBC Continental Americas super middleweight title |
| 50 | Win | 47–1–1 (1) | Brian Vera | UD | 10 | 28 Sep 2013 | StubHub Center, Carson, California, U.S. | |
| 49 | Loss | 46–1–1 (1) | Sergio Martínez | UD | 12 | 15 Sep 2012 | Thomas & Mack Center, Paradise, Nevada, U.S. | Lost WBC middleweight title;For The Ring middleweight title |
| 48 | Win | 46–0–1 (1) | Andy Lee | TKO | 7 (12), 2:21 | 16 Jun 2012 | Sun Bowl, El Paso, Texas, U.S. | Retained WBC middleweight title |
| 47 | Win | 45–0–1 (1) | Marco Antonio Rubio | UD | 12 | 4 Feb 2012 | Alamodome, San Antonio, Texas, U.S. | Retained WBC middleweight title |
| 46 | Win | 44–0–1 (1) | Peter Manfredo Jr. | TKO | 5 (12), 1:52 | 19 Nov 2011 | Reliant Arena, Houston, Texas, U.S. | Retained WBC middleweight title |
| 45 | Win | 43–0–1 (1) | Sebastian Zbik | MD | 12 | 4 Jun 2011 | Staples Center, Los Angeles, California, U.S. | Won WBC middleweight title |
| 44 | Win | 42–0–1 (1) | Billy Lyell | UD | 10 | 29 Jan 2011 | Estadio Banorte, Culiacán, Mexico | Retained WBC Silver middleweight title |
| 43 | Win | 41–0–1 (1) | John Duddy | UD | 12 | 26 Jun 2010 | Alamodome, San Antonio, Texas, U.S. | Won vacant WBC Silver middleweight title |
| 42 | NC | 40–0–1 (1) | Troy Rowland | UD | 10 | 14 Nov 2009 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Originally a UD win for Chávez Jr., later ruled an NC after he failed a drug test |
| 41 | Win | 40–0–1 | Jason LeHoullier | TKO | 1 (10), 2:43 | 12 Sep 2009 | Palenque de La Feria, Tepic, Mexico | Retained WBC Latino super welterweight title |
| 40 | Win | 39–0–1 | Luciano Cuello | UD | 10 | 28 Mar 2009 | Bullring by the Sea, Tijuana, Mexico | Won WBC Latino super welterweight title |
| 39 | Win | 38–0–1 | Matt Vanda | UD | 10 | 1 Nov 2008 | Mandalay Bay Events Center, Paradise, Nevada, U.S. | |
| 38 | Win | 37–0–1 | Matt Vanda | SD | 10 | 12 Jul 2008 | Palenque ExpoGan, Hermosillo, Mexico | |
| 37 | Win | 36–0–1 | Tobia Giuseppe Loriga | KO | 9 (10), 1:47 | 26 Apr 2008 | Plaza de Toros Santa María, Querétaro City, Mexico | Retained WBC Continental Americas super welterweight title |
| 36 | Win | 35–0–1 | José Celaya | TKO | 8 (12), 2:14 | 9 Feb 2008 | Domo de la Feria, León, Mexico | Won WBC Continental Americas super welterweight title |
| 35 | Win | 34–0–1 | Ray Sánchez | KO | 6 (10), 1:33 | 1 Dec 2007 | Tingley Coliseum, Albuquerque, New Mexico, U.S. | |
| 34 | Win | 33–0–1 | Louis Brown | TKO | 5 (10), 2:42 | 4 Aug 2007 | Allstate Arena, Rosemont, Illinois, U.S. | |
| 33 | Win | 32–0–1 | Grover Wiley | KO | 3 (10), 2:27 | 9 Jun 2007 | Madison Square Garden, New York City, New York, U.S. | |
| 32 | Win | 31–0–1 | Anthony Shuler | KO | 2 (10), 1:32 | 14 Apr 2007 | Alamodome, San Antonio, Texas, U.S. | |
| 31 | Win | 30–0–1 | Raúl Jorge Muñoz | TKO | 3 (10), 1:29 | 9 Mar 2007 | Dodge Arena, Hidalgo, Texas, U.S. | |
| 30 | Win | 29–0–1 | Christian Solano | UD | 10 | 16 Dec 2006 | Plaza de Toros, Culiacán, Mexico | |
| 29 | Win | 28–0–1 | Shad Howard | RTD | 4 (8), 0:10 | 23 Sep 2006 | Dodge Arena, Hidalgo, Texas, U.S. | |
| 28 | Win | 27–0–1 | Jermaine White | TKO | 4 (10), 1:52 | 19 Aug 2006 | Don Haskins Center, El Paso, Texas, U.S. | Won vacant WBC Youth super welterweight title |
| 27 | Win | 26–0–1 | Aaron Drake | TKO | 2 (6), 1:53 | 10 Jun 2006 | Madison Square Garden, New York City, New York, U.S. | |
| 26 | Win | 25–0–1 | Tyler Ziolkowski | KO | 2 (6), 2:40 | 8 Apr 2006 | Thomas & Mack Center, Paradise, Nevada, U.S. | |
| 25 | Win | 24–0–1 | Carlos Molina | MD | 6 | 18 Feb 2006 | The New Aladdin, Paradise, Nevada, U.S. | |
| 24 | Draw | 23–0–1 | Carlos Molina | PTS | 6 | 16 Dec 2005 | Monterrey Arena, Monterrey, Mexico | |
| 23 | Win | 23–0 | Jeremy Stiers | TKO | 5 (6), 0:47 | 8 Oct 2005 | Thomas & Mack Center, Paradise, Nevada, U.S. | |
| 22 | Win | 22–0 | Corey Alarcon | TKO | 2 (6), 0:35 | 17 Sep 2005 | America West Arena, Phoenix, Arizona, U.S. | |
| 21 | Win | 21–0 | Jonathan Nelson | KO | 1 (6), 0:54 | 12 Aug 2005 | Entertainment Center, Laredo, Texas, U.S. | |
| 20 | Win | 20–0 | Rubén Galván | TKO | 4 (8), 2:22 | 25 Jun 2005 | Boardwalk Hall, Atlantic City, New Jersey, U.S. | |
| 19 | Win | 19–0 | Adam Wynant | KO | 1 (6), 0:42 | 28 May 2005 | Staples Center, Los Angeles, California, U.S. | |
| 18 | Win | 18–0 | Travis Hartman | TKO | 3 (8), 0:51 | 22 Apr 2005 | Dodge Arena, Hidalgo, Texas, U.S. | |
| 17 | Win | 17–0 | Ryan Maraldo | TKO | 3 (6), 2:56 | 19 Mar 2005 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | |
| 16 | Win | 16–0 | Leroy Newton | TKO | 1 (6), 2:11 | 11 Feb 2005 | Convention Center, San Diego, California, U.S. | |
| 15 | Win | 15–0 | Jose Cruz | TKO | 2 (8) | 21 Jan 2005 | Parque Revolución, Culiacán, Mexico | |