| No. | Result | Record | Opponent | Type | Round, time | Date | Location | Notes |
| 115 | Loss | 107–6–2 | Grover Wiley | RTD | 4 (10), 3:00 | Sep 17, 2005 | America West Arena, Phoenix, Arizona, U.S. | |
| 114 | Win | 107–5–2 | Ivan Robinson | UD | 10 | May 28, 2005 | Staples Center, Los Angeles, California, U.S. | |
| 113 | Win | 106–5–2 | Frankie Randall | UD | 10 | May 22, 2004 | Plaza de Toros, Mexico City, Mexico | |
| 112 | Win | 105–5–2 | Willy Wise | TKO | 2 (10) | Nov 22, 2003 | Centro de Espectáculos Alamar, Tijuana, Mexico | |
| 111 | Win | 104–5–2 | Terry Thomas | TKO | 2 (10), 0:50 | Nov 24, 2001 | Plaza de Toros Monumental, Ciudad Juárez, Mexico | |
| 110 | Loss | 103–5–2 | Kostya Tszyu | TKO | 6 (12), 1:28 | Jul 29, 2000 | Veteran's Memorial Coliseum, Phoenix, Arizona, U.S. | For WBC light welterweight title |
| 109 | Win | 103–4–2 | Buck Smith | TKO | 3 (10) | Dec 18, 1999 | Culiacán, Mexico | |
| 108 | Loss | 102–4–2 | Willy Wise | UD | 10 | Oct 2, 1999 | Las Vegas Hilton, Winchester, Nevada, U.S. | |
| 107 | Win | 102–3–2 | Marty Jakubowski | TKO | 4 (10) | Jul 10, 1999 | Plaza de Toros Calafia, Mexicali, Mexico | |
| 106 | Win | 101–3–2 | Verdell Smith | TKO | 4 (10), 1:36 | Apr 1, 1999 | Don Haskins Center, El Paso, Texas, U.S. | |
| 105 | Loss | 100–3–2 | Oscar De La Hoya | RTD | 8 (12), 3:00 | Sep 18, 1998 | Thomas & Mack Center, Paradise, Nevada, U.S. | For WBC welterweight title |
| 104 | Win | 100–2–2 | Ken Sigurani | TKO | 3 (10), 2:09 | Jun 25, 1998 | Foxwoods Resort Casino, Ledyard, Connecticut, U.S. | |
| 103 | Draw | 99–2–2 | Miguel Ángel González | SD | 12 | Mar 7, 1998 | Plaza de Toros, Mexico City, Mexico | For vacant WBC light welterweight title |
| 102 | Win | 99–2–1 | Larry LaCoursiere | UD | 10 | Jun 28, 1997 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | |
| 101 | Win | 98–2–1 | Tony Martin | UD | 10 | Mar 29, 1997 | Las Vegas Hilton, Winchester, Nevada, U.S. | |
| 100 | Win | 97–2–1 | Joey Gamache | TKO | 8 (10), 3:00 | Oct 12, 1996 | Arrowhead Pond, Anaheim, California, U.S. | |
| 99 | Loss | 96–2–1 | Oscar De La Hoya | TKO | 4 (12), 2:37 | Jun 7, 1996 | Caesars Palace, Paradise, Nevada, U.S. | Lost WBC light welterweight title |
| 98 | Win | 96–1–1 | Scott Walker | TKO | 2 (10), 2:45 | Feb 9, 1996 | Caesars Palace, Paradise, Nevada, U.S. | |
| 97 | Win | 95–1–1 | David Kamau | UD | 12 | Sep 16, 1995 | The Mirage, Paradise, Nevada, U.S. | Retained WBC light welterweight title |
| 96 | Win | 94–1–1 | Craig Houk | KO | 1 (10), 1:19 | Jul 29, 1995 | United Center, Chicago, Illinois, U.S. | |
| 95 | Win | 93–1–1 | Giovanni Parisi | UD | 12 | Apr 8, 1995 | Caesars Palace, Paradise, Nevada, U.S. | Retained WBC light welterweight title |
| 94 | Win | 92–1–1 | Tony Lopez | TKO | 10 (12), 1:41 | Dec 10, 1994 | Estadio de Béisbol, Monterrey, Mexico | Retained WBC light welterweight title |
| 93 | Win | 91–1–1 | Meldrick Taylor | TKO | 8 (12), 1:41 | Sep 17, 1994 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Retained WBC light welterweight title |
| 92 | Win | 90–1–1 | Frankie Randall | TD | 8 (12), 2:57 | May 7, 1994 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Won WBC light welterweight title;Split TD after Chávez was cut from an accidental head clash |
| 91 | Loss | 89–1–1 | Frankie Randall | SD | 12 | Jan 29, 1994 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Lost WBC light welterweight title |
| 90 | Win | 89–0–1 | Andy Holligan | TKO | 5 (12) | Dec 18, 1993 | Estadio Cuauhtémoc, Puebla City, Mexico | Retained WBC light welterweight title |
| 89 | Win | 88–0–1 | Mike Powell | TKO | 4 (10) | Oct 30, 1993 | Ciudad Juárez, Mexico | |
| 88 | Draw | 87–0–1 | Pernell Whitaker | MD | 12 | Sep 10, 1993 | Alamodome, San Antonio, Texas, U.S. | For WBC welterweight title |
| 87 | Win | 87–0 | Terrence Alli | TKO | 6 (12), 0:45 | May 8, 1993 | Thomas & Mack Center, Paradise, Nevada, U.S. | Retained WBC light welterweight title |
| 86 | Win | 86–0 | Silvio Walter Rojas | KO | 3 (10), 2:05 | Apr 10, 1993 | Auditorio Benito Juárez, Guadalajara, Mexico | |
| 85 | Win | 85–0 | Greg Haugen | TKO | 5 (12), 2:02 | Feb 20, 1993 | Estadio Azteca, Mexico City, Mexico | Retained WBC light welterweight title |
| 84 | Win | 84–0 | Marty Jakubowski | TKO | 6 (10), 0:18 | Dec 13, 1992 | The Mirage, Paradise, Nevada, U.S. | |
| 83 | Win | 83–0 | Bruce Pearson | KO | 3 (10), 1:30 | Oct 31, 1992 | Culiacán, Mexico | |
| 82 | Win | 82–0 | Héctor Camacho | UD | 12 | Sep 12, 1992 | Thomas & Mack Center, Paradise, Nevada, U.S. | Retained WBC light welterweight title |
| 81 | Win | 81–0 | Frankie Mitchell | TKO | 4 (12), 0:56 | Aug 1, 1992 | Las Vegas Hilton, Winchester, Nevada, U.S. | Retained WBC light welterweight title |
| 80 | Win | 80–0 | Angel Hernandez | TKO | 5 (12), 1:11 | Apr 10, 1992 | Toreo de Cuatro Caminos, Mexico City, Mexico | Retained WBC light welterweight title |
| 79 | Win | 79–0 | Juan Soberanes Ramos | KO | 4 (10) | Mar 13, 1992 | La Paz, Mexico | |
| 78 | Win | 78–0 | Ignacio Perdomo | RTD | 7 (10), 3:00 | Dec 13, 1991 | Hermosillo, Mexico | |
| 77 | Win | 77–0 | Jorge Alberto Melian | KO | 4 (10), 1:36 | Nov 12, 1991 | Mexico City, Mexico | |
| 76 | Win | 76–0 | Lonnie Smith | UD | 12 | Sep 14, 1991 | The Mirage, Paradise, Nevada, U.S. | Retained WBC light welterweight title |
| 75 | Win | 75–0 | Tommy Small | KO | 4 (10), 0:56 | Apr 26, 1991 | Estadio General Ángel Flores, Culiacán, Mexico | |
| 74 | Win | 74–0 | John Duplessis | TKO | 4 (12), 2:42 | Mar 18, 1991 | The Mirage, Paradise, Nevada, U.S. | Retained WBC and IBF light welterweight titles |
| 73 | Win | 73–0 | Kyung-Duk Ahn | TKO | 3 (12), 2:14 | Dec 8, 1990 | Convention Hall, Atlantic City, New Jersey, U.S. | Retained WBC and IBF light welterweight titles |
| 72 | Win | 72–0 | Jaime Balboa | TKO | 4 (10), 2:10 | Nov 8, 1990 | Mazatlán, Mexico | |
| 71 | Win | 71–0 | Russell Mosley | KO | 3 (10) | Aug 18, 1990 | Culiacán, Mexico | |
| 70 | Win | 70–0 | Akwei Addo | KO | 2 (10) | Jul 5, 1990 | Palacio de Deportes, Madrid, Spain | |
| 69 | Win | 69–0 | Meldrick Taylor | TKO | 12 (12), 2:58 | Mar 17, 1990 | Las Vegas Hilton, Winchester, Nevada, U.S. | Retained WBC light welterweight title;Won IBF light welterweight title |
| 68 | Win | 68–0 | Alberto de las Mercedes Cortes | TKO | 3 (12), 1:56 | Dec 16, 1989 | Palacio de los Deportes, Mexico City, Mexico | Retained WBC light welterweight title |
| 67 | Win | 67–0 | Sammy Fuentes | RTD | 10 (12), 3:00 | Nov 18, 1989 | Caesars Palace, Paradise, Nevada, U.S. | Retained WBC light welterweight title |