| Res. | Record | Opponent | Method | Event | Date | Round | Time | Location | Notes |
| Win | 28–1 (1) | Stipe Miocic | TKO (spinning back kick and punches) | UFC 309 | November 16, 2024 | 3 | 4:29 | New York City, New York, United States | Defended the UFC Heavyweight Championship. Broke the record for overall title defenses in UFC history (12). Performance of the Night. Later vacated title after deciding to retire. |
| Win | 27–1 (1) | Ciryl Gane | Submission (guillotine choke) | UFC 285 | March 4, 2023 | 1 | 2:04 | Las Vegas, Nevada, United States | Heavyweight debut. Won the vacant UFC Heavyweight Championship. Performance of the Night. |
| Win | 26–1 (1) | Dominick Reyes | Decision (unanimous) | UFC 247 | February 8, 2020 | 5 | 5:00 | Houston, Texas, United States | Defended the UFC Light Heavyweight Championship. Extended the record for overall UFC Light Heavyweight title defenses (11). Later vacated the title. |
| Win | 25–1 (1) | Thiago Santos | Decision (split) | UFC 239 | July 6, 2019 | 5 | 5:00 | Las Vegas, Nevada, United States | Defended the UFC Light Heavyweight Championship. |
| Win | 24–1 (1) | Anthony Smith | Decision (unanimous) | UFC 235 | March 2, 2019 | 5 | 5:00 | Las Vegas, Nevada, United States | Defended the UFC Light Heavyweight Championship. Jones was deducted two points in round 4 due to an illegal knee. |
| Win | 23–1 (1) | Alexander Gustafsson | KO (punches) | UFC 232 | December 29, 2018 | 3 | 2:02 | Inglewood, California, United States | Won the vacant UFC Light Heavyweight Championship. |
| NC | 22–1 (1) | Daniel Cormier | NC (overturned) | UFC 214 | July 29, 2017 | 3 | 3:01 | Anaheim, California, United States | For the UFC Light Heavyweight Championship. Performance of the Night. Originally a KO (head kick and punches) win for Jones; overturned and stripped of the title after he tested positive for a turinabol metabolite. |
| Win | 22–1 | Ovince Saint Preux | Decision (unanimous) | UFC 197 | April 23, 2016 | 5 | 5:00 | Las Vegas, Nevada, United States | Won the interim UFC Light Heavyweight Championship. Later stripped of the title after he tested positive for clomiphene and letrozole. |
| Win | 21–1 | Daniel Cormier | Decision (unanimous) | UFC 182 | January 3, 2015 | 5 | 5:00 | Las Vegas, Nevada, United States | Defended the UFC Light Heavyweight Championship. Extended the record for most consecutive UFC Light Heavyweight title defenses (8). Fight of the Night. Later stripped of the title after he violated the UFC athlete conduct policy. |
| Win | 20–1 | Glover Teixeira | Decision (unanimous) | UFC 172 | April 26, 2014 | 5 | 5:00 | Baltimore, Maryland, United States | Defended the UFC Light Heavyweight Championship. |
| Win | 19–1 | Alexander Gustafsson | Decision (unanimous) | UFC 165 | September 21, 2013 | 5 | 5:00 | Toronto, Ontario, Canada | Defended the UFC Light Heavyweight Championship. Broke the record for the most consecutive UFC Light Heavyweight title defenses (6). Fight of the Night. |
| Win | 18–1 | Chael Sonnen | TKO (elbows and punches) | UFC 159 | April 27, 2013 | 1 | 4:33 | Newark, New Jersey, United States | Defended the UFC Light Heavyweight Championship. |
| Win | 17–1 | Vitor Belfort | Submission (keylock) | UFC 152 | September 22, 2012 | 4 | 0:54 | Toronto, Ontario, Canada | Defended the UFC Light Heavyweight Championship. Submission of the Night. |
| Win | 16–1 | Rashad Evans | Decision (unanimous) | UFC 145 | April 21, 2012 | 5 | 5:00 | Atlanta, Georgia, United States | Defended the UFC Light Heavyweight Championship. |
| Win | 15–1 | Lyoto Machida | Technical Submission (guillotine choke) | UFC 140 | December 10, 2011 | 2 | 4:26 | Toronto, Ontario, Canada | Defended the UFC Light Heavyweight Championship. Fight of the Night. |
| Win | 14–1 | Quinton Jackson | Submission (rear-naked choke) | UFC 135 | September 24, 2011 | 4 | 1:14 | Denver, Colorado, United States | Defended the UFC Light Heavyweight Championship. Fight of the Night. |
| Win | 13–1 | Maurício Rua | TKO (punches and knees) | UFC 128 | March 19, 2011 | 3 | 2:37 | Newark, New Jersey, United States | Won the UFC Light Heavyweight Championship. |
| Win | 12–1 | Ryan Bader | Submission (guillotine choke) | UFC 126 | February 5, 2011 | 2 | 4:20 | Las Vegas, Nevada, United States | Submission of the Night. |
| Win | 11–1 | Vladimir Matyushenko | TKO (elbows) | UFC Live: Jones vs. Matyushenko | August 1, 2010 | 1 | 1:52 | San Diego, California, United States | |
| Win | 10–1 | Brandon Vera | TKO (elbows and punches) | UFC Live: Vera vs. Jones | March 21, 2010 | 1 | 3:19 | Broomfield, Colorado, United States | Knockout of the Night. |
| Loss | 9–1 | Matt Hamill | DQ (illegal elbows) | The Ultimate Fighter: Heavyweights Finale | December 5, 2009 | 1 | 4:14 | Las Vegas, Nevada, United States | |
| Win | 9–0 | Jake O'Brien | Submission (guillotine choke) | UFC 100 | July 11, 2009 | 2 | 2:43 | Las Vegas, Nevada, United States | |
| Win | 8–0 | Stephan Bonnar | Decision (unanimous) | UFC 94 | January 31, 2009 | 3 | 5:00 | Las Vegas, Nevada, United States | |
| Win | 7–0 | André Gusmão | Decision (unanimous) | UFC 87 | August 9, 2008 | 3 | 5:00 | Minneapolis, Minnesota, United States | |
| Win | 6–0 | Moyses Gabin | TKO (punches) | Battle Cage Xtreme 5 | July 12, 2008 | 2 | 1:58 | Atlantic City, New Jersey, United States | Won the USKBA Light Heavyweight Championship. |
| Win | 5–0 | Parker Porter | KO (punch) | World Championship Fighting 3 | June 20, 2008 | 1 | 0:36 | Wilmington, Massachusetts, United States | |
| Win | 4–0 | Ryan Verrett | TKO (punches) | United States Fight League: War in the Woods 3 | May 9, 2008 | 1 | 0:14 | Ledyard, Connecticut, United States | |
| Win | 3–0 | Anthony Pina | Submission (guillotine choke) | ICE Fighter | April 25, 2008 | 1 | 1:15 | Worcester, Massachusetts, United States | |
| Win | 2–0 | Carlos Eduardo | KO (punches) | Battle Cage Xtreme 4 | April 19, 2008 | 3 | 0:24 | Atlantic City, New Jersey, United States | Light Heavyweight debut. |
| Win | 1–0 | Brad Bernard | TKO (punches) | Full Force Productions: Untamed 20 | April 12, 2008 | 1 | 1:32 | Boxborough, Massachusetts, United States | Catchweight (210 lb) bout. |