| Year | Single | Peak chart positions | Album |
| US | US Cashbox | US R&B | US Country | US AC | CANCHUM /RPM | CAN Country | UK |
| 1958 | "Dreamy Eyes" /"Well I'm Your Man" (from Words and Music by Johnny Tillotson EP) | 6387 | —— | —— | —— | —— | —— | —— | —— | Johnny Tillotson's Best |
| "I'm Never Gonna Kiss You" (with Genevieve) | — | — | — | — | — | — | — | — | Non-album single |
| 1959 | "True True Happiness"b/w "Love Is Blind" (non-album track) | 54 | 49 | — | — | — | — | — | — | Johnny Tillotson's Best |
| 1960 | "Why Do I Love You So"b/w "Never Let Me Go" (non-album track) | 42 | 31 | — | — | — | 25 | — | — |
| "Earth Angel" / "Pledging My Love"* | 5763* | 6173 | —— | —— | —— | —— | —— | —— |
| "Poetry in Motion"b/w "Princess Princess" | 2 | 2 | 27 | — | — | 6 | — | 1 |
| 1961 | "Jimmy's Girl"b/w "(Little Sparrow) His True Love Said Goodbye" | 25 | 24 | — | — | — | 29 | — | 43 |
| "Without You"b/w "Cutie Pie" | 7 | 12 | — | — | — | 15 | — | — |
| 1962 | "Dreamy Eyes" (re-issue)b/w "Well I'm Your Man" (from Words and Music by Johnny Tillotson EP) | 35 | 46 | — | — | — | 14 | — | — |
| "It Keeps Right On a-Hurtin b/w "She Gave Sweet Love to Me" (non-album track) | 3 | 5 | 6 | 4 | — | 10 | — | 31 | It Keeps Right On a-Hurtin' |
| "Send Me the Pillow You Dream On" / | 17 | 14 | — | 11 | 5 | 37 | — | 21 |
| "What'll I Do" | 106 | — | — | — | — | — | — | — |
| "I'm So Lonesome I Could Cry" / | 89 | 94 | — | — | — | — | — | — |
| "I Can't Help It (If I'm Still in Love with You)" | 24 | 29 | — | — | 8 | 23 | — | 41 |
| 1963 | "Out of My Mind"b/w "Empty Feelin (from You Can Never Stop Me Loving You) | 24 | 23 | — | — | 11 | 28 | — | 34 | Non-album single |
| "You Can Never Stop Me Loving You"b/w "Judy, Judy, Judy" | 18 | 18 | — | — | 4 | 12 | — | — | You Can Never Stop Me Loving You |
| "Talk Back Trembling Lips"b/w "Another You" | 7 | 7 | — | — | 6 | — | — | — | Talk Back Trembling Lips |
| "Funny How Time Slips Away"b/w "A Very Good Year for Girls" | 50 | 62 | — | — | 16 | — | — | — | It Keeps Right On a-Hurtin' |
| 1964 | "I'm a Worried Guy" / | 37 | 38 | — | — | — | 39 | — | — | Talk Back Trembling Lips |
| "Please Don't Go Away" | 112 | 122 | — | — | — | — | — | — |
| "I Rise, I Fall"b/w "I'm Watching My Watch" | 36— | 44125 | —— | —— | —— | —— | —— | —— | The Tillotson Touch |
| "Worry"b/w "Sufferin' from a Heartache" | 45 | 45 | — | — | 5 | 36 | — | — |
| "She Understands Me"b/w "Tomorrow" | 31 | 29 | — | — | 4 | 25 | — | — | She Understands Me |
| 1965 | "Angel"b/w "Little Boy" (from She Understands Me) | 51 | 53 | — | — | — | 33 | — | — | Johnny Tillotson Sings |
| "Then I'll Count Again"b/w "One's Yours, One's Mine" (from Johnny Tillotson Sings) | 86 | 67 | — | — | — | – | — | — | That's My Style |
| "Heartaches by the Number"b/w "Your Mem'ry Comes Along" | 35 | 32 | — | — | 4 | 14 | — | — |
| "Our World"b/w "(Wait Till You See) My Gidget" | 70 | 54 | — | — | — | 23 | — | — | Johnny Tillotson Sings |
| 1966 | "Hello Enemy"b/w "I Never Loved You Anyway" (from Johnny Tillotson Sings) | 128 | 104 | — | — | — | — | — | — | Non-album single |
| "Me, Myself and I"b/w "Country Boy" | — | — | — | — | — | — | — | — | That's My Style |
| "No Love at All"b/w "What Am I Gonna Do" (from Talk Back Trembling Lips) | — | — | — | — | — | — | — | — | No Love at All |
| "Open Up Your Heart"b/w "More Than Before" | — | — | — | — | — | — | — | — | Non-album single |
| "Christmas Is the Best of All"b/w "Christmas Country Style" | — | — | — | — | — | — | — | — | The Christmas Touch |
| 1967 | "Tommy Jones"b/w "Strange Things Happen" (from Johnny Tillotson Sings) | — | 91 | — | — | — | — | — | — | Here I Am |
| "Don't Tell Me It's Raining"b/w "Takin' It Easy" | — | — | — | — | — | — | — | — |
| "You're the Reason"b/w "Countin' My Teardrops" (from That's My Style) | — | — | — | 48 | — | — | 24 | — | The Best of Johnny Tillotson |
| 1968 | "I Can Spot a Cheater"b/w "It Keeps Right On a-Hurtin (from The Best of Johnny Tillotson) | — | — | — | 63 | — | — | — | — | Non-album singles |
| "Why So Lonely"b/w "I Haven't Begun to Love You Yet" | — | — | — | — | — | — | — | — |
| "Letter to Emily"b/w "Your Memory Comes Along" | — | — | — | — | — | — | — | — |
| 1969 | "Tears on My Pillow"b/w "Remember When" | 119 | 98 | — | — | — | 94 | — | — | Tears on My Pillow |
| "Joy to the World"b/w "What Am I Living For" | — | — | — | — | — | — | — | — |
| "Raining in My Heart"b/w "Today I Started Loving You Again" | — | — | — | — | — | — | — | — |
| 1970 | "Susan"b/w "Love Waits for Me" | — | — | — | — | — | — | — | — | Non-album singles |
| "I Don't Believe in If Anymore"b/w "Kansas City, Kansas" | — | — | — | — | — | — | — | — |
| 1971 | "Apple Bend"b/w "Star Spangled Bus" (non-album track) | 127 | — | — | — | — | — | — | — | Johnny Tillotson (1970) |
| "Welfare Hero"b/w "The Flower Kissed the Shoes That Jesus Wore" | — | — | — | — | — | — | — | — |
| "Make Me Believe"b/w "The Flower Kissed the Shoes That Jesus Wore" | — | — | — | — | — | — | — | — |
| 1973 | "Your Love's Been a Long Time Comin b/w "Apple Bend" | — | — | — | — | — | — | — | — |
| "If You Wouldn't Be My Lady"b/w "The Sunshine of My Life" | — | — | — | — | — | — | 77 | — | Non-album singles |