| Television |
| Year | Title | Role | Notes |
| 1982–1988 | St. Elsewhere | Dr. Wayne Fiscus | 137 episodes |
| 1984 | Match Game/Hollywood Squares Hour | Himself | Panelist |
| School | TV movie |
| The Princess Who Had Never Laughed | Weinerhead Waldo | |
| Welcome to the Fun Zone | — | TV movie Writer |
| 1984–1985 | Muppet Babies | Skeeter/Animal/Bunsen | Voice 26 Episodes |
| 1985 | Howie Mandel: Live from Carnegie Mall | Himself | Executive producer Writer |
| Little Muppet Monsters | | Episode 1: "In the Beginning" |
| 1985–1986 | Faerie Tale Theatre | Wienerhead Waldo/Guest Interviewee | 2 Episodes |
| 1986 | The Young Comedians All-Star Reunion | Himself | Writer - Uncredited |
| David Letterman's 2nd Annual Holiday Film Festival | Locker Room Guy | Segment: "The Iceman Hummeth" Uncredited |
| 1987 | Howie from Maui | Himself | TV movie Executive producer Writer |
| 1990 | Carol & Company | Steve | Season 1 episode 7: "Myna and the Messenger" |
| Mother Goose Rock 'n' Rhyme | Humpty Dumpty | TV movie |
| 1990–1991 | Good Grief | Ernie Lapidus | Main 13 Episodes |
| 1990–1998 | Bobby's World | Self/Bobby Generic/Howard Generic | 81 episodes Executive producer |
| 1991 | Howie and Rose | Howie Newman | TV pilot |
| 1992 | Howie | Various | Executive producer |
| The Amazing Live Sea Monkeys | The Professor | 11 episodes Executive producer |
| 1993 | David Copperfield | Mealy (Dog) | TV movie Voice |
| 1994 | In Search of Dr. Seuss | Sam-I-Am | Voice Television movie |
| 1995 | Homicide: Life on the Street | Interior Decorator | Season 3 episode 9: "Every Mother's Son" |
| Harrison Bergeron | Charlie | TV movie |
| The Ben Stiller Show | Himself | Uncredited Episode 13: "ZooTV at Night" |
| Howie Mandel's Sunny Skies | Director Executive producer (2 episodes) Host (2 episodes) Writer (1 episode) |
| Highjacker | — | TV short Executive producer |
| Hello There | — |
| Brunch | — |
| 1996 | Bless This House | Stuart Wyler | Episode 16: "Natural Born Parents" |
| Lois & Clark: The New Adventures of Superman | Mr. Mxyzptlk | Season 4 episode 11: "Twas the Night Before Mxymas" |
| 1997 | The Outer Limits | Karl Durand | Season 3 episode 2: "Second Thoughts" |
| 1998 | The Nanny | Howie Mandel | Season 6 episode 8: "Making Whoopi" |
| 1998–1999 | The Howie Mandel Show | Host | Executive producer Writer Segment director (1 episode) |
| 1999 | Sunset Beach | "Jerry Show" Announcer | Episode |
| Jackie's Back! | Himself | TV movie |
| 2000 | Timothy Tweedle the First Christmas Elf | Comet |
| 2001 | Spinning Out of Control | Marty Levinne |
| 2002–2003 | Hollywood Squares | Himself | Center square 25 episodes |
| 2003 | Untitled Howie Mandel Project | | TV movie |
| 2004 | Crown Heights | Rabbi |
| 2005 | Hidden Howie: The Private Life of a Public Nuisance | Himself | Executive producer |
| Punk'd | — | Executive producer - Season 6 episode 3: "David Boreanaz, Kristin Cavallari & Terrell Owens" |
| 2005–2019 | Deal or No Deal | Host | |
| 2006 | Las Vegas | Himself | Season 3 episode 16: "Coyote Ugly" |
| MADtv | Season 12 episode 2 |
| Studio 60 on the Sunset Strip | Episode 10: "B-12" |
| The Great American Christmas | Narrator | TV movie |
| The Great Polar Bear Adventure | Pupa | Voice TV movie |
