| Secretary of State for the Home DepartmentIncluding constituencies for elected MPs. | Term of office | Party | Ministry | Monarch(Reign) |
| | | William Petty2nd Earl of Shelburne | 27 March 1782 | 10 July 1782 | Whig | Rockingham II | George III(1760–1820) |
| | | Thomas TownsendMP for Whitchurch | 10 July 1782 | 2 April 1783 | Whig | Shelburne(Whig–Tory) |
| | | Frederick NorthLord NorthMP for Banbury | 2 April 1783 | 19 December 1783 | Tory | Fox–North |
| | | George Nugent-Temple-Grenville3rd Earl Temple | 19 December 1783 | 23 December 1783 | Tory | Pitt I |
| | | Thomas Townsend1st Baron Sydney | 23 December 1783 | 5 June 1789 | Whig |
| | | William Grenville1st Baron GrenvilleMP for Buckinghamshire(1759–1834) | 5 June 1789 | 8 June 1791 | Tory |
| | | Henry DundasMP for Edinburgh | 8 June 1791 | 11 July 1794 | Tory |
| | | William Cavendish-Bentinck3rd Duke of Portland | 11 July 1794 | 30 July 1801 | Tory |
| Addington |
| | | Thomas Pelham4th Baron Pelham of Stanmer | 30 July 1801 | 17 August 1803 | Whig |
| | | Charles Philip YorkeMP for Cambridgeshire | 17 August 1803 | 12 May 1804 | Tory |
| | | Robert Jenkinson2nd Baron Hawkesbury | 12 May 1804 | 5 February 1806 | Tory | Pitt II |
| | | George Spencer2nd Earl Spencer | 5 February 1806 | 25 March 1807 | Whig | All the Talents(Whig–Tory) |
| | | Robert Jenkinson2nd Earl of Liverpool | 25 March 1807 | 1 November 1809 | Tory | Portland II |
| | | Richard RyderMP for Tiverton | 1 November 1809 | 8 June 1812 | Tory | Perceval |
| | | Henry Addington1st Viscount Sidmouth | 11 June 1812 | 17 January 1822 | Tory | Liverpool |
| | George IV(1820–1830) |
| | | Robert PeelMP for Oxford University | 17 January 1822 | 10 April 1827 | Tory |
| | | William Sturges BourneMP for Ashburton | 30 April 1827 | 16 July 1827 | Tory | Canning(Canningite–Whig) |
| | | Henry Petty-Fitzmaurice3rd Marquess of Lansdowne | 16 July 1827 | 22 January 1828 | Whig |
| | Goderich |
| | | Robert PeelMP for 3 constituencies respectively(1788–1850) | 26 January 1828 | 22 November 1830 | Tory | Wellington–Peel |
| | William IV(1830–1837) |
| | | William Lamb2nd Viscount Melbourne | 22 November 1830 | 16 July 1834 | Whig | Grey |
| | | John Ponsonby1st Baron Duncannon | 19 July 1834 | 15 November 1834 | Whig | Melbourne I |
| | | Arthur Wellesley1st Duke of Wellington | 15 November 1834 | 15 December 1834 | Tory | Wellington Caretaker |
| | | Henry GoulburnMP for Cambridge University | 15 December 1834 | 18 April 1835 | Conservative | Peel I |
| | | Lord John RussellMP for Stroud | 18 April 1835 | 30 August 1839 | Whig | Melbourne II |
| | Victoria(1837–1901) |
| | | Constantine Phipps1st Marquess of Normanby | 30 August 1839 | 30 August 1841 | Whig |
| | | Sir James Graham2nd BaronetMP for Dorchester | 6 September 1841 | 30 June 1846 | Conservative | Peel II |
| | | Sir George Grey2nd BaronetMP for Devonport →North Northumberland(1799–1882) | 8 July 1846 | 23 February 1852 | Whig | Russell I |
| | | Spencer Horatio WalpoleMP for Midhurst | 27 February 1852 | 19 December 1852 | Conservative | Who? Who? |
| | | Henry John Temple3rd Viscount PalmerstonMP for Tiverton | 28 December 1852 | 6 February 1855 | Whig | Aberdeen(Peelite–Whig) |
| | | Sir George Grey2nd BaronetMP for Morpeth | 8 February 1855 | 26 February 1858 | Whig | Palmerston I |
| | | Spencer Horatio WalpoleMP for Cambridge University | 26 February 1858 | 3 March 1859 | Conservative | Derby–Disraeli II |
| | | Thomas Henry Sutton Sotheron-EstcourtMP for North Wiltshire | 3 March 1859 | 18 June 1859 | Conservative |
| | | George Cornewall LewisMP for Radnor | 18 June 1859 | 25 July 1861 | Liberal | Palmerston II |
| | | Sir George Grey2nd BaronetMP for Morpeth | 25 July 1861 | 28 June 1866 | Liberal |
| | Russell II |
| | | Spencer Horatio WalpoleMP for Cambridge University | 6 July 1866 | 17 May 1867 | Conservative | Derby–Disraeli III |
| | | Gathorne Gathorne-HardyMP for Oxford University | 17 May 1867 | 3 December 1868 | Conservative |
| | | Henry BruceMP for Merthyr Tydfil →Renfrewshire(1815–1895) | 9 December 1868 | 9 August 1873 | Liberal | Gladstone I |
| | | Robert LoweMP for London University | 9 August 1873 | 20 February 1874 | Liberal |
| | | R. A. CrossMP for South West Lancashire | 21 February 1874 | 23 April 1880 | Conservative | Disraeli II |
| | | William HarcourtMP for Derby | 28 April 1880 | 23 June 1885 | Liberal | Gladstone II |
| | | R. A. CrossMP for Newton | 24 June 1885 | 1 February 1886 | Conservative | Salisbury I |
| | | Hugh ChildersMP for Edinburgh South | 6 February 1886 | 25 July 1886 | Liberal | Gladstone III |
| | | Henry MatthewsMP for Birmingham East | 3 August 1886 | 15 August 1892 | Conservative | Salisbury II |