Grey's Anatomy season 22
Updated: 12/10/2025, 4:40:55 PM Wikipedia source
The twenty-second season of the American medical drama television series Grey's Anatomy was announced on April 3, 2025, and premiered in the United States on the American Broadcasting Company (ABC) on October 9, 2025. This is the first season not to feature Jake Borelli and Midori Francis as series regulars since the sixteenth and nineteenth seasons, respectively.
Infobox
Showrunner
Meg Marinis
Starring
mw- Ellen Pompeo Chandra Wilson James Pickens, Jr. Kevin McKidd Caterina Scorsone Camilla Luddington Jason George Kim Raver Chris Carmack Anthony Hill Alexis Floyd Harry Shum Jr. Adelaide Kane Niko Terho Trevor Jackson
No. of episodes
6
Original network
ABC
Original release
October 9, 2025 (2025-10-09) –present
Tables
· Episodes
449
449
No.overall
449
No. inseason
1
Title
"Only the Strong Survive"
Directed by
Debbie Allen
Written by
Meg Marinis
Original release date
October 9, 2025 (2025-10-09)
U.S. viewers(millions)
2.61
After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.
After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.
No.overall
After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.
450
450
No.overall
450
No. inseason
2
Title
"We Built This City"
Directed by
Kevin McKidd
Written by
Zoanne Clack
Original release date
October 16, 2025 (2025-10-16)
U.S. viewers(millions)
2.22
The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations. Ben accepts the position of chief resident and Meredith and Maggie spend time with Amelia.
The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations. Ben accepts the position of chief resident and Meredith and Maggie spend time with Amelia.
No.overall
The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations. Ben accepts the position of chief resident and Meredith and Maggie spend time with Amelia.
451
451
No.overall
451
No. inseason
3
Title
"Between Two Lungs"
Directed by
Debbie Allen
Written by
Sandra Hamada
Original release date
October 23, 2025 (2025-10-23)
U.S. viewers(millions)
2.16
A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance.
A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance.
No.overall
A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance.
452
452
No.overall
452
No. inseason
4
Title
"Goodbye Horses"
Directed by
Sammi Cannold
Written by
Jase Miles-Perez
Original release date
October 30, 2025 (2025-10-30)
U.S. viewers(millions)
2.13
The interns juggle a bizarre trauma, while a complex breast reconstruction forces Meredith into a tense partnership.
The interns juggle a bizarre trauma, while a complex breast reconstruction forces Meredith into a tense partnership.
No.overall
The interns juggle a bizarre trauma, while a complex breast reconstruction forces Meredith into a tense partnership.
453
453
No.overall
453
No. inseason
5
Title
"Sometimes I Feel Like a Motherless Child"
Directed by
Bille Woodruff
Written by
Jess Righthand
Original release date
November 6, 2025 (2025-11-06)
U.S. viewers(millions)
2.04
Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation.
Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation.
No.overall
Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation.
454
454
No.overall
454
No. inseason
6
Title
"When I Crash"
Directed by
Phylicia Rashad
Written by
Michelle Lirtzman
Original release date
November 13, 2025 (2025-11-13)
U.S. viewers(millions)
1.84
Grey Sloan takes in patients following a catastrophic bus accident. Teddy and Owen have an awkward encounter, and Richard tests Bailey’s patience.
Grey Sloan takes in patients following a catastrophic bus accident. Teddy and Owen have an awkward encounter, and Richard tests Bailey’s patience.
No.overall
Grey Sloan takes in patients following a catastrophic bus accident. Teddy and Owen have an awkward encounter, and Richard tests Bailey’s patience.
455
455
No.overall
455
No. inseason
7
Title
"Skyfall"
Directed by
TBA
Written by
Carol Brown
Original release date
January 8, 2026 (2026-01-08)
U.S. viewers(millions)
TBD
456
456
No.overall
456
No. inseason
8
Title
"Heavy On Me"
Directed by
TBA
Written by
Tameson Duffy
Original release date
January 15, 2026 (2026-01-15)
U.S. viewers(millions)
TBD
457
457
No.overall
457
No. inseason
9
Title
TBA
Directed by
Kim Raver
Written by
Julie Wong
Original release date
January 22, 2026 (2026-01-22)
U.S. viewers(millions)
TBD
458
458
No.overall
458
No. inseason
10
Title
"Strip That Down"
Directed by
Kevin McKidd
Written by
TBA
Original release date
January 29, 2026 (2026-01-29)
U.S. viewers(millions)
TBD
| No.overall | No. inseason | Title | Directed by | Written by | Original release date | viewers(millions) | |
| 449 | 1 | "Only the Strong Survive" | Debbie Allen | Meg Marinis | October 9, 2025 (2025-10-09) | 2.61 | |
| After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation. | |||||||
| 450 | 2 | "We Built This City" | Kevin McKidd | Zoanne Clack | October 16, 2025 (2025-10-16) | 2.22 | |
| The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations. Ben accepts the position of chief resident and Meredith and Maggie spend time with Amelia. | |||||||
| 451 | 3 | "Between Two Lungs" | Debbie Allen | Sandra Hamada | October 23, 2025 (2025-10-23) | 2.16 | |
| A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance. | |||||||
| 452 | 4 | "Goodbye Horses" | Sammi Cannold | Jase Miles-Perez | October 30, 2025 (2025-10-30) | 2.13 | |
| The interns juggle a bizarre trauma, while a complex breast reconstruction forces Meredith into a tense partnership. | |||||||
| 453 | 5 | "Sometimes I Feel Like a Motherless Child" | Bille Woodruff | Jess Righthand | November 6, 2025 (2025-11-06) | 2.04 | |
| Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation. | |||||||
| 454 | 6 | "When I Crash" | Phylicia Rashad | Michelle Lirtzman | November 13, 2025 (2025-11-13) | 1.84 | |
| Grey Sloan takes in patients following a catastrophic bus accident. Teddy and Owen have an awkward encounter, and Richard tests Bailey’s patience. | |||||||
| 455 | 7 | "Skyfall" | TBA | Carol Brown | January 8, 2026 (2026-01-08) | TBD | |
| 456 | 8 | "Heavy On Me" | TBA | Tameson Duffy | January 15, 2026 (2026-01-15) | TBD | |
| 457 | 9 | TBA | Kim Raver | Julie Wong | January 22, 2026 (2026-01-22) | TBD | |
| 458 | 10 | "Strip That Down" | Kevin McKidd | TBA | January 29, 2026 (2026-01-29) | TBD | |
Viewership and ratings per episode of Grey's Anatomy season 22 · Reception › Ratings
1
1
No.
1
Title
"Only the Strong Survive"
Air date
October 9, 2025
Timeslot (ET)
Thursday 10:00 p.m.
Rating/share(18–49)
0.3/3
Viewers(millions)
2.61
DVR(18–49)
—
DVR viewers(millions)
—
Total(18–49)
—
Total viewers(millions)
—
2
2
No.
2
Title
"We Built This City"
Air date
October 16, 2025
Timeslot (ET)
0.2/2
Rating/share(18–49)
2.20
Viewers(millions)
—
DVR(18–49)
—
DVR viewers(millions)
—
Total(18–49)
—
3
3
No.
3
Title
"Between Two Lungs"
Air date
October 23, 2025
Timeslot (ET)
0.2/3
Rating/share(18–49)
2.16
Viewers(millions)
—
DVR(18–49)
—
DVR viewers(millions)
—
Total(18–49)
—
4
4
No.
4
Title
"Goodbye Horses"
Air date
October 30, 2025
Timeslot (ET)
0.2/3
Rating/share(18–49)
2.13
Viewers(millions)
—
DVR(18–49)
—
DVR viewers(millions)
—
Total(18–49)
—
5
5
No.
5
Title
"Sometimes I Feel Like a Motherless Child"
Air date
November 6, 2025
Timeslot (ET)
0.2/2
Rating/share(18–49)
2.04
Viewers(millions)
—
DVR(18–49)
—
DVR viewers(millions)
—
Total(18–49)
—
6
6
No.
6
Title
"When I Crash"
Air date
November 13, 2025
Timeslot (ET)
0.1/2
Rating/share(18–49)
1.84
Viewers(millions)
—
DVR(18–49)
—
DVR viewers(millions)
—
Total(18–49)
—
| No. | Title | Air date | Timeslot (ET) | Rating/share(18–49) | Viewers(millions) | DVR(18–49) | DVR viewers(millions) | Total(18–49) | Total viewers(millions) | Ref. |
| 1 | "Only the Strong Survive" | October 9, 2025 | Thursday 10:00 p.m. | 0.3/3 | 2.61 | — | — | — | — | |
| 2 | "We Built This City" | October 16, 2025 | 0.2/2 | 2.20 | — | — | — | — | ||
| 3 | "Between Two Lungs" | October 23, 2025 | 0.2/3 | 2.16 | — | — | — | — | ||
| 4 | "Goodbye Horses" | October 30, 2025 | 0.2/3 | 2.13 | — | — | — | — | ||
| 5 | "Sometimes I Feel Like a Motherless Child" | November 6, 2025 | 0.2/2 | 2.04 | — | — | — | — | ||
| 6 | "When I Crash" | November 13, 2025 | 0.1/2 | 1.84 | — | — | — | — |
References
- Varietyhttps://variety.com/2025/tv/news/9-1-1-greys-anatomy-the-rookie-shifting-gears-will-trent-renewed-abc-1236359024/
- Deadline Hollywoodhttps://deadline.com/2025/07/abc-greys-anatomy-9-1-1-nashville-premiere-dates-1236473298/
- Shondalandhttps://www.shondaland.com/shondaland-series/greys-anatomy/grey-s-anatomy-showrunner-meg-marinis-on-that-shocking-mid-season-finale-two-big-departures-and-what-s-coming-next
- The Futon Critichttp://www.thefutoncritic.com/showatch/greys-anatomy/listings/
- Writers Guild of America Westhttps://directories.wga.org/project/691370/greys-anatomy/
- 9-1-1: Nashvillehttps://programminginsider.com/thursday-ratings-9-1-1-nashville-on-abc-has-okay-debut/
- Programming Insiderhttps://programminginsider.com/thursday-ratings-cbs-leads-broadcast-networks-among-total-viewers-year-over-year-erosion-in-key-demos-for-linear-overall/
- Ghostshttps://programminginsider.com/thursday-ratings-ghosts-on-cbs-earns-top-18-49-and-25-54-demos-among-prime-time-broadcast-network-telecasts/
- Programming Insiderhttps://programminginsider.com/thursday-ratings-cbs-and-abc-battle-for-demo-supremacy-among-broadcast-networks/
- Wicked: One Wonderful Nighthttps://programminginsider.com/thursday-ratings-nbc-musical-special-wicked-one-wonderful-night-tops-its-time-slot-in-demos-among-broadcast-shows/
- Programming Insiderhttps://programminginsider.com/thursday-ratings-26th-annual-latin-grammy-awards-televised-on-univision/
- Deadline Hollywoodhttps://deadline.com/2025/10/greys-anatomy-trevor-jackson-jade-pettyjohn-anita-kalathara-1236573970/
- TVLinehttps://tvline.com/lists/2025-fall-tv-schedule-returning-shows-preview/
- TVLinehttps://www.tvline.com/2005250/sophia-bush-greys-anatomy-season-22-episode-3-video/
- Varietyhttps://variety.com/2025/tv/news/kate-walsh-greys-anatomy-season-22-guest-star-1236600004/
- Deadline Hollywoodhttps://deadline.com/2025/04/greys-anatomy-renewed-season-22-abc-ellen-pompeo-cast-1236358105/
- People Magazinehttps://people.com/chandra-wilson-after-20-years-it-is-time-to-watch-greys-anatomy-exclusive-11734391
- "Backstory… Tonight I'm re-watching the season finale again to prepare for filming tmw. And suddenly.. Matt decides he needs to blend a smoothie. At 8pm.. during this scene.. I had to start recording 😂"https://www.instagram.com/p/DMy-JrgR8rw/
- Varietyhttps://variety.com/2025/tv/news/greys-anatomy-9-1-1-nashville-premiere-dates-1236473391/
- Varietyhttps://variety.com/2025/tv/news/ellen-pompeo-greys-anatomy-storylines-streaming-residuals-1236380723/
- TV Insiderhttps://www.tvinsider.com/1184821/greys-anatomy-season-22-cast-premiere-date-details/
- Deadline Hollywoodhttps://deadline.com/2025/10/greys-anatomy-catarina-scorsone-amelia-hiatus-return-1236589898/
- Deadline Hollywoodhttps://deadline.com/2025/11/greys-anatomy-james-pickens-jr-prostate-cancer-diagnosis-1236618685/
- CNNhttps://www.cnn.com/2025/11/14/entertainment/greys-anatomy-james-pickens-jr-prostate-cancer