| Year(s) | Title | Role | Notes |
| 2002 | Fidel | Chucho Osorio | |
| The Brothers García | Mr. Fender | Episode: "The Student Buddy" |
| Curb Your Enthusiasm | Himself | |
| 2002–07 | George Lopez | George Lopez | 120 episodesWon – Imagen Award for Best Actor – Television (2004)[citation needed]Nominated – NAACP Image Award for Outstanding Actor in a Comedy Series (2004–07)Teen Choice Award for Choice TV Breakout Star – MaleYoung Artist Award for Most Popular Mom & Pop in a Television Series (shared with Constance Marie; 2004) |
| 2004 | Naughty or Nice | Henry Ramiro | |
| 2006 | Freddie | George | Episode: "Freddie Gets Cross Over" |
| 2007 | America's Mexican | Himself | HBO special |
| 2007–08 | The Naked Brothers Band | Himself | 5 episodes |
| 2008 2022 | Reno 911! | Mayor of Reno | 4 episodes |
| 2009 | Mr. Troop Mom | Eddie Serrano | Nickelodeon filmNominated – ALMA Award for Outstanding TV Comedy ActorNominated – Teen Choice Award for Choice Summer TV Star: Male |
| 2009 | Tall, Dark, & Chicano | Himself | HBO special |
| 2009–11 | Lopez Tonight | Himself/host | Nominated – People's Choice Award for Favorite Talk Show Host (2011) |
| 2012 | Take Me Out | Himself/host | |
| 2012 | It's Not Me, It's You | Himself | HBO special |
| 2013 | Shake It Up | George Martinez | Episode: "In The Bag It Up" |
| 2014 | Saint George | George | Series regular (10 episodes); also creator and executive producer |
| 2015 | Real Rob | Himself | Episode: "Cleaning House" |
| 2016–17 | Lopez | Himself | Series regular and executive-producer24 episodes |
| 2016 | America's Got Talent | Himself (guest judge) | Episode: "Judge Cuts 2" |
| 2017 | The Comedy Get Down | Himself | |
| 2018 | The Garbage Man Show | Beach Man | Episode: "This is the End" |
| 2019–21 | The Casagrandes | Ernesto Estrella | Voice, 3 episodes |
| 2020 | Harley Quinn | Himself | Voice, episode: "There's No Place to Go But Down" |
| 2020 | Jimmy Kimmel Live! | Himself | Guest host |
| 2021 | The Neighborhood | Victor Alvarez | Episode: "Welcome to the Challenge" |
| 2021 | Victor and Valentino | José Guadalupe Posada | Voice, episode: "Finding Posada" |
| 2022–25 | Lopez vs Lopez | George Lopez | Also creator / executive producer, |
| 2022 | The Loud House | Ernesto Estrella | Voice, episode: "Great Lakes Freakout!" |
