| No. | Result | Record | Opponent | Type | Round, time | Date | Age | Location | Notes |
| 81 | Loss | 76–5 | Shannon Briggs | MD | 12 | Nov 22, 1997 | 48 years, 316 days | Etess Arena, Atlantic City, New Jersey, U.S. | |
| 80 | Win | 76–4 | Lou Savarese | SD | 12 | Apr 26, 1997 | 48 years, 106 days | Convention Hall, Atlantic City, New Jersey, U.S. | Retained WBU heavyweight title |
| 79 | Win | 75–4 | Crawford Grimsley | UD | 12 | Nov 3, 1996 | 47 years, 298 days | NK Hall, Urayasu, Japan | Retained WBU heavyweight title;Won vacant IBA heavyweight title |
| 78 | Win | 74–4 | Axel Schulz | MD | 12 | Apr 22, 1995 | 46 years, 102 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Retained IBF heavyweight title;Won vacant WBU heavyweight title |
| 77 | Win | 73–4 | Michael Moorer | KO | 10 (12), 2:03 | Nov 5, 1994 | 45 years, 299 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Won WBA and IBF heavyweight titles |
| 76 | Loss | 72–4 | Tommy Morrison | UD | 12 | Jun 7, 1993 | 44 years, 148 days | Thomas & Mack Center, Paradise, Nevada, U.S. | For vacant WBO heavyweight title |
| 75 | Win | 72–3 | Pierre Coetzer | TKO | 8 (10), 1:48 | Jan 16, 1993 | 44 years, 6 days | Convention Center, Reno, Nevada, U.S. | |
| 74 | Win | 71–3 | Alex Stewart | MD | 10 | Apr 11, 1992 | 43 years, 92 days | Thomas & Mack Center, Paradise, Nevada, U.S. | |
| 73 | Win | 70–3 | Jimmy K. Ellis | TKO | 3 (10), 1:36 | Dec 7, 1991 | 42 years, 331 days | Convention Center, Reno, Nevada, U.S. | |
| 72 | Loss | 69–3 | Evander Holyfield | UD | 12 | Apr 19, 1991 | 42 years, 99 days | Convention Hall, Atlantic City, New Jersey, U.S. | For WBA, WBC, and IBF heavyweight titles |
| 71 | Win | 69–2 | Terry Anderson | KO | 1 (10), 2:59 | Sep 25, 1990 | 41 years, 258 days | London Arena, London, England | |
| 70 | Win | 68–2 | Ken Lakusta | KO | 3 (10), 1:24 | Jul 31, 1990 | 41 years, 202 days | Northlands AgriCom, Edmonton, Alberta, Canada | |
| 69 | Win | 67–2 | Adilson Rodrigues | KO | 2 (10), 2:39 | Jun 16, 1990 | 41 years, 157 days | Caesars Palace, Paradise, Nevada, U.S. | |
| 68 | Win | 66–2 | Mike Jameson | TKO | 4 (10), 2:16 | Apr 17, 1990 | 41 years, 97 days | Caesars Tahoe, Stateline, Nevada, U.S. | |
| 67 | Win | 65–2 | Gerry Cooney | KO | 2 (10), 1:57 | Jan 15, 1990 | 41 years, 5 days | Convention Hall, Atlantic City, New Jersey, U.S. | |
| 66 | Win | 64–2 | Everett Martin | UD | 10 | Jul 20, 1989 | 40 years, 191 days | Convention Center, Tucson, Arizona, U.S. | |
| 65 | Win | 63–2 | Bert Cooper | RTD | 2 (10), 3:00 | Jun 1, 1989 | 40 years, 142 days | Pride Pavilion, Phoenix, Arizona, U.S. | |
| 64 | Win | 62–2 | J. B. Williamson | TKO | 5 (10), 1:37 | Apr 30, 1989 | 40 years, 110 days | Moody Gardens Hotel Spa, Galveston, Texas, U.S. | |
| 63 | Win | 61–2 | Manoel De Almeida | TKO | 3 (10), 2:14 | Feb 16, 1989 | 40 years, 37 days | Atlantis Theater, Orlando, Florida, U.S. | |
| 62 | Win | 60–2 | Mark Young | TKO | 7 (10), 1:47 | Jan 26, 1989 | 40 years, 16 days | Community War Memorial, Rochester, New York, U.S. | |
| 61 | Win | 59–2 | David Jaco | TKO | 1 (10), 2:03 | Dec 28, 1988 | 39 years, 353 days | Casa Royal Banquet Hall, Bakersfield, California, U.S. | |
| 60 | Win | 58–2 | Tony Fulilangi | TKO | 2 (10), 2:26 | Oct 27, 1988 | 39 years, 291 days | Civic Center, Marshall, Texas, U.S. | |
| 59 | Win | 57–2 | Bobby Hitz | TKO | 1 (10), 2:59 | Sep 10, 1988 | 39 years, 244 days | The Palace, Auburn Hills, Michigan, U.S. | |
| 58 | Win | 56–2 | Ladislao Mijangos | TKO | 2 (10), 2:42 | Aug 25, 1988 | 39 years, 228 days | Lee County Civic Center, Fort Myers, Florida, U.S. | |
| 57 | Win | 55–2 | Carlos Hernández | TKO | 4 (10), 1:36 | Jun 26, 1988 | 39 years, 168 days | Tropworld Casino and Entertainment Resort, Atlantic City, New Jersey, U.S. | |
| 56 | Win | 54–2 | Frank Lux | TKO | 3 (10), 2:07 | May 21, 1988 | 39 years, 132 days | Sullivan Arena, Anchorage, Alaska, U.S. | |
| 55 | Win | 53–2 | Dwight Muhammad Qawi | TKO | 7 (10), 1:51 | Mar 19, 1988 | 39 years, 69 days | Caesars Palace, Paradise, Nevada, U.S. | |
| 54 | Win | 52–2 | Guido Trane | TKO | 5 (10), 2:39 | Feb 5, 1988 | 39 years, 26 days | Caesars Palace, Paradise, Nevada, U.S. | |
| 53 | Win | 51–2 | Tom Trimm | KO | 1 (10), 0:45 | Jan 23, 1988 | 39 years, 13 days | Sheraton Twin Towers, Orlando, Florida, U.S. | |
| 52 | Win | 50–2 | Rocky Sekorski | TKO | 3 (10), 2:48 | Dec 18, 1987 | 38 years, 342 days | Bally's Las Vegas, Paradise, Nevada, U.S. | |
| 51 | Win | 49–2 | Tim Anderson | TKO | 4 (10), 2:23 | Nov 21, 1987 | 38 years, 315 days | Eddie Graham Sports Complex, Orlando, Florida, U.S. | |
| 50 | Win | 48–2 | Bobby Crabtree | TKO | 6 (10) | Sep 15, 1987 | 38 years, 248 days | The Hitchin' Post, Springfield, Missouri, U.S. | |
| 49 | Win | 47–2 | Charles Hostetter | KO | 3 (10), 2:01 | Jul 9, 1987 | 38 years, 180 days | County Coliseum, Oakland, California, U.S. | |
| 48 | Win | 46–2 | Steve Zouski | TKO | 4 (10), 2:47 | Mar 9, 1987 | 38 years, 58 days | ARCO Arena, Sacramento, California, U.S. | |
| 47 | Loss | 45–2 | Jimmy Young | UD | 12 | Mar 17, 1977 | 28 years, 66 days | Roberto Clemente Coliseum, San Juan, Puerto Rico | |
| 46 | Win | 45–1 | Pedro Agosto | TKO | 4 (10), 2:34 | Jan 22, 1977 | 28 years, 12 days | Civic Center, Pensacola, Florida, U.S. | |
| 45 | Win | 44–1 | John "Dino" Denis | TKO | 4 (10), 2:25 | Oct 15, 1976 | 27 years, 279 days | Sportatorium, Hollywood, Florida, U.S. | |
| 44 | Win | 43–1 | Scott LeDoux | TKO | 3 (10), 2:58 | Aug 14, 1976 | 27 years, 217 days | Memorial Auditorium, Utica, New York, U.S. | |
| 43 | Win | 42–1 | Joe Frazier | TKO | 5 (12), 2:26 | Jun 15, 1976 | 27 years, 157 days | Nassau Veterans Memorial Coliseum, Hempstead, New York, U.S. | Retained NABF heavyweight title |
| 42 | Win | 41–1 | Ron Lyle | KO | 5 (12), 2:28 | Jan 24, 1976 | 27 years, 14 days | Caesars Palace, Paradise, Nevada, U.S. | Won vacant NABF heavyweight title |
| 41 | Loss | 40–1 | Muhammad Ali | KO | 8 (15), 2:58 | Oct 30, 1974 | 25 years, 293 days | Stade du 20 Mai, Kinshasa, Zaire | Lost WBA, WBC, and The Ring heavyweight titles |
| 40 | Win | 40–0 | Ken Norton | TKO | 2 (15), 2:00 | Mar 26, 1974 | 25 years, 75 days | Poliedro, Caracas, Venezuela | Retained WBA, WBC, and The Ring heavyweight titles |
| 39 | Win | 39–0 | José Roman | KO | 1 (15), 2:00 | Sep 1, 1973 | 24 years, 234 days | Nippon Budokan, Tokyo, Japan | Retained WBA, WBC, and The Ring heavyweight titles |
| 38 | Win | 38–0 | Joe Frazier | TKO | 2 (15), 2:26 | Jan 22, 1973 | 24 years, 12 days | National Stadium, Kingston, Jamaica | Won WBA, WBC, and The Ring heavyweight titles |
| 37 | Win | 37–0 | Terry Sorrell | KO | 2 (10), 1:05 | Oct 10, 1972 | 23 years, 274 days | Salt Palace, Salt Lake City, Utah, U.S. | |
| 36 | Win | 36–0 | Miguel Angel Paez | KO | 2 (10), 2:29 | May 11, 1972 | 23 years, 122 days | County Coliseum Arena, Oakland, California, U.S. | Won Pan American heavyweight title |
| 35 | Win | 35–0 | Ted Gullick | KO | 2 (10), 2:28 | Apr 10, 1972 | 23 years, 91 days | The Forum, Inglewood, California, U.S. | |
| 34 | Win | 34–0 | Clarence Boone | KO | 2 (10), 2:55 | Mar 7, 1972 | 23 years, 57 days | Civic Center, Beaumont, Texas, U.S. | |
| 33 | Win | 33–0 | Joe Murphy Goodwin | KO | 2 (10) | Feb 29, 1972 | 23 years, 50 days | Municipal Auditorium, Austin, Texas, U.S. | |