| Title | Year | Peak chart positions | Certifications | Album |
| ITA | AUT | BEL(Wa) | FRA | GER | LTU | NLD | NOR | SWE | SWI |
| "Time to Rock" | 2002 | 33 | — | — | — | — | — | — | — | — | — | | Gabry Ponte |
| "Geordie" | 9 | — | — | — | — | — | — | — | — | — | |
| "De musica tonante" | 2003 | 13 | — | — | — | — | — | — | — | — | — | |
| "Music" (with Fargetta) | 75 | — | — | — | — | — | — | — | — | — | |
| "The Man in the Moon" | 30 | — | — | — | — | — | — | — | — | — | |
| "Giulia" (with DJ Lhasa) | 16 | — | — | — | — | — | — | — | — | — | | Non-album single |
| "La danza delle streghe" | 7 | — | — | — | — | — | — | — | — | — | FIMI: Gold | Dr. Jekyll & Mister DJ |
| "Figli di Pitagora"(featuring Little Tony) | 2004 | 13 | — | — | 66 | — | — | — | — | — | — | |
| "Sin pararse" (with Ye Man) | 20 | — | — | — | — | — | — | — | — | — | | Non-album single |
| "Depends on You" | 2005 | 13 | — | — | — | — | — | — | — | — | — | | Dr. Jekyll & Mister DJ |
| "Sono già solo (Remix)" | 2010 | 51 | — | — | — | — | — | — | — | — | — | | Dance and Love – The Selection Vol. 3 |
| "Beat on My Drum"(featuring Pitbull and Sophia Del Carmen) | 2012 | 85 | — | — | — | — | — | — | — | — | — | | Non-album singles |
| "La fine del mondo"(featuring Two Fingerz) | 2014 | 7 | — | — | — | — | — | — | — | — | — | |
| "Buonanotte giorno" | 7 | — | — | — | — | — | — | — | — | — | |
| "Che ne sanno i 2000"(featuring Danti) | 2016 | 22 | — | — | — | — | — | — | — | — | — | FIMI: 2× Platinum |
| "Tu sei"(featuring Danti) | 2017 | 45 | — | — | — | — | — | — | — | — | — | FIMI: Gold |
| "Monster"(with Lum!x) | 2019 | — | 52 | 37 | 41 | 20 | — | — | — | — | 55 | FIMI: Gold BVMI: 2× Platinum IFPI AUT: 3× Platinum SNEP: Diamond |
| "The Passenger (LaLaLa)"(with Lum!x and Mokaby and D.T.E) | 2020 | — | 47 | — | 128 | 58 | — | — | — | — | — | BVMI: Gold IFPI AUT: Platinum |
| "Lonely"(with Jerome) | — | — | — | — | 77 | — | — | — | — | — | |
| "Golden" (with Blasterjaxx featuring Riell) | 2021 | — | — | — | — | — | — | — | — | — | — | |
| "Oh La La" (with Moti featuring Mougleta) | — | — | — | — | — | — | — | — | — | — | |
| "Going Down" (with Lucky Luke and Kevin Palms) | — | — | — | — | — | — | — | — | — | — | |
| "Thunder"(with Lum!x and Prezioso) | 42 | 36 | 5 | 18 | 79 | — | 14 | 5 | 7 | 20 | FIMI: 2× Platinum BVMI: Gold IFPI AUT: Platinum IFPI NOR: 3× Platinum SNEP: Diamond |
| "The Portrait (Ooh La La)" (with R3hab) | — | — | — | — | — | — | — | — | — | — | |
| "Superman" (with Roberto Molinaro) | — | — | — | — | — | — | — | — | — | |
| "The Feeling" (with Henri PFR) | — | — | 40 | — | — | — | — | — | — | — | |
| "Can't Get Over You" (featuring Aloe Blacc) | — | — | — | — | — | — | — | — | — | — | |
| "Call Me"(with R3hab and Timmy Trumpet) | 2022 | — | — | — | — | — | — | 80 | — | — | — | |
| "Hasta La Vista" (with Blasterjaxx) | — | — | — | — | — | — | — | — | — | — | |
| "We Could Be Together"(with Lum!x and Daddy DJ) | 93 | — | — | 96 | — | — | 34 | — | — | — | FIMI: Gold SNEP: Gold |
| "Rely on Me"(with Sigala and Alex Gaudino) | — | — | — | — | — | — | — | — | — | — | | Every Cloud – Silver Linings |
| "Dance Dance"(with Alessandra) | 2023 | — | — | — | — | — | — | — | — | — | — | | Non-album singles |
| "Let You Down"(with Dvbbs featuring Sofiloud) | 2024 | — | — | — | — | — | — | — | — | — | — | |
| "Born to Love Ya"(with Sean Paul and Natti Natasha) | — | — | — | — | — | — | 76 | — | — | — | |
| "Tutta l'Italia" | 2025 | 14 | — | — | — | — | 32 | — | — | 91 | — | |
| "Exotica" | — | — | — | 94 | — | — | — | — | — | — | SNEP: Gold |
| "Brokenhearted" (with Train) | | | | | | | | | | | |
| "Rave Music" (with Nicky Romero) | | | | | | | | | | | |
| "Pretty Women(All Around The World)" (with Azteck and Pitbull) | | | | | | | | | | | |
| "I Don't Know"(with Erika) | — | — | — | — | — | — | — | — | — | — | |
| "—" denotes a recording that did not chart or was not released. |
