| Year | Title | Role | Notes | Ref. |
| 2010 | Last Comic Standing | Herself | 4 episodes | |
| 2011–2013 | After Lately | Herself | 14 episodes | |
| 2011–2014 | Chelsea Lately | Round table co-host | 158 episodes | |
| 2014 | 2 Broke Girls | Sherlock Mary | "And the Near Death Experience" | |
| Workaholics | Jo | "Timechair" | |
| Mulaney | Mary Jo | 3 episodes | |
| 2015 | Glee | Butch Melman | "We Built This Glee Club" | |
| 2015 | Hot Girls Walk By | Ruth | "Visitors in a Hospital" | |
| 2015 | Married | Woman on Rascal | "Mother's Day" | |
| 2015 | Drunk History | Herself | "New Mexico" | |
| 2015-2017 | The Mindy Project | Collette Kimball-Kinney | Main role (Seasons 4–6); 39 episodes | |
| 2016 | Go-Go Boy Interrupted | Fortune | Web series | |
| 2016–2019 | Life in Pieces | Dougie | 7 episodes | |
| 2017 | Chelsea | Ann Coulter / Sarah Huckabee Sanders | 5 episodes | |
| The Standups | Herself | Episode: "With Fortune Feimster" | |
| 2017–2018 | Nobodies | Libby | 2 episodes | |
| 2017–2019 | RuPaul's Drag Race | Herself | 3 episodes (including "RuPaul Roast" and "L.A.D.P.!") | |
| 2018 | Another Period | Garva | 3 episodes | |
| Dear White People | Christine Halberg | Episode: "Volume 2: Chapter IV" | |
| Champions | Ruby | 10 episodes | |
| Claws | Lauren Zorloni | "Crossroads" | |
| Foursome | Kimmy | Episode: "Stay Linked - Get Inked" | |
| Niko and the Sword of Light | Brohilda (voice) | Episode: "The Thorn of Contention" | |
| The Fix | Herself | "Let's Fix Artificial Intelligence" | |
| 2018–2023 | Summer Camp Island | Ava / various (voice) | 25 episodes | |
| 2018–2024 | Craig of the Creek | Laura Mercer (voice) | 7 episodes | |
| 2019 | Historical Roasts | Princess Diana | Episode: "Freddie Mercury" | |
| Tales of The City | Carlin | "A Touch o' Butch" | |
| American Princess | Sherl | Episode: "You Can Always Trust Your Vaganya" | |
| Sunnyside | Michelle Pinholster | "Pants Full of Sandwiches" | |
| The Simpsons | Evelyn (voice) | Episode: "Livin La Pura Vida" | |
| 2019–2020 | The L Word: Generation Q | Heather | 3 episodes | |
| 2019–2021 | Bless the Harts | Brenda (voice) | 26 episodes | |
| 2020 | Sweet and Salty | Herself | Netflix Stand-Up Special | |
| Nailed It! | Herself | Episode: "The One with the 90's Theme" | |
| 2021 | iCarly | Countess Debra | Episode: "iGot Your Back" | |
| The Mighty Ones | Vibez (voice) | "Bumbleberry/Leaf's Still Cool" | |
| Q-Force | Louisa Deck (voice) | 3 episodes | |
| Awkwafina Is Nora from Queens | Deimos | 2 episodes | |
| RuPaul's Drag Race All Stars | Herself | "Snatch Game of Love" | |
| 2021–2022 | Ada Twist, Scientist | Rosie's Mom (voice) | 4 episodes | |
| Kenan | Pam Fox | 14 episodes | |
| 2022 | Is It Cake? | Herself (judge) | "Fast Food Fakeout" | |
| Madagascar: A Little Wild | Manager Cow (voice) | "A Lil Baa Country" | |
| 2022–2023 | Firebuds | Flip / Flap (voice) | 7 episodes | |
| 2023 | Frog and Toad | Lizard (voice) | 2 episodes | |
| Ten Year Old Tom | — (voice) | "Crossing Guard/Poker Game" | |
| Strange Planet | Megafan / Elderly Being (voice) | "The Flying Machine" | |
| 2023–2024 | Velma | Olive (voice) | 15 episodes | |
