| Year | Award | Category | Film | Result | Notes |
| 2005 | Primetime Emmy Awards | Outstanding Writing for a Variety, Music or Comedy Program | Da Ali G Show | Nominated | Shared with Seth Rogen and other writing staff |
| 2008 | Canadian Comedy Awards | Best Writing – Film | Superbad | Won | Shared with Seth Rogen |
| 2012 | Golden Globe Awards | Best Motion Picture – Musical or Comedy | 50/50 | Nominated | Shared with Seth Rogen and Ben Karlin |
| Independent Spirit Awards | Best Feature Film | Nominated | Shared with Seth Rogen and Ben Karlin |
| 2013 | Canadian Screen Awards | Best Screenplay | Goon | Nominated | Shared with Jay Baruchel |
| 2021 | Primetime Emmy Awards | Outstanding Drama Series | The Boys | Nominated | Shared with producers |
| 2022 | Primetime Emmy Awards | Outstanding Limited or Anthology Series | Pam & Tommy | Nominated | Shared with producers |
| Outstanding Short Form Animated Program | The Boys Presents: Diabolical | Nominated | Shared with producers |
| 2024 | Annie Awards | Outstanding Achievement for Writing in an Animated Feature Production | Teenage Mutant Ninja Turtles: Mutant Mayhem | Nominated | Shared with Seth Rogen, Jeff Rowe, Dan Hernandez and Benji Samit |
| 2025 | Primetime Emmy Awards | Outstanding Comedy Series | The Studio | Won | Shared with Seth Rogen and other producers |
| Outstanding Directing for a Comedy Series | Won | Shared with Seth Rogen |
| Outstanding Writing for a Comedy Series | Won | Shared with Seth Rogen, Peter Huyck, Alex Gregory, and Frida Perez |