| No. | Result | Record | Opponent | Type | Round, time | Date | Location | Notes |
| 29 | Loss | 28–1 | Terence Crawford | TKO | 9 (12), 2:32 | Jul 29, 2023 | T-Mobile Arena, Paradise, Nevada, U.S. | Lost WBA (Super), WBC, and IBF welterweight titles; For WBO and vacant The Ring welterweight titles |
| 28 | Win | 28–0 | Yordenis Ugás | TKO | 10 (12), 1:44 | Apr 16, 2022 | AT&T Stadium, Arlington, Texas, U.S. | Retained WBC and IBF welterweight titles;Won WBA (Super) welterweight title |
| 27 | Win | 27–0 | Danny Garcia | UD | 12 | Dec 5, 2020 | AT&T Stadium, Arlington, Texas, U.S. | Retained WBC and IBF welterweight titles |
| 26 | Win | 26–0 | Shawn Porter | SD | 12 | Sep 28, 2019 | Staples Center, Los Angeles, California, U.S. | Retained IBF welterweight title;Won WBC welterweight title |
| 25 | Win | 25–0 | Mikey Garcia | UD | 12 | Mar 16, 2019 | AT&T Stadium, Arlington, Texas, U.S. | Retained IBF welterweight title |
| 24 | Win | 24–0 | Carlos Ocampo | KO | 1 (12), 3:00 | Jun 16, 2018 | Ford Center at The Star, Frisco, Texas, U.S. | Retained IBF welterweight title |
| 23 | Win | 23–0 | Lamont Peterson | RTD | 7 (12), 3:00 | Jan 20, 2018 | Barclays Center, New York City, New York, U.S. | Retained IBF welterweight title |
| 22 | Win | 22–0 | Kell Brook | KO | 11 (12), 1:47 | May 27, 2017 | Bramall Lane, Sheffield, England | Won IBF welterweight title |
| 21 | Win | 21–0 | Leonard Bundu | KO | 6 (12), 2:06 | Aug 21, 2016 | Ford Amphitheater at Coney Island, New York City, New York, U.S. | |
| 20 | Win | 20–0 | Chris Algieri | TKO | 5 (10), 0:48 | Apr 16, 2016 | Barclays Center, New York City, New York, U.S. | |
| 19 | Win | 19–0 | Alejandro Barrera | TKO | 5 (12), 1:46 | Nov 28, 2015 | The Bomb Factory, Dallas, Texas, U.S. | |
| 18 | Win | 18–0 | Chris van Heerden | TKO | 8 (10), 0:50 | Sep 11, 2015 | Ricoh Coliseum, Toronto, Ontario, Canada | |
| 17 | Win | 17–0 | Phil Lo Greco | TKO | 3 (10), 1:50 | Jun 20, 2015 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | |
| 16 | Win | 16–0 | Samuel Vargas | TKO | 4 (10), 1:45 | Apr 11, 2015 | Barclays Center, New York City, New York, U.S. | |
| 15 | Win | 15–0 | Francisco Javier Castro | TKO | 5 (8), 2:43 | Dec 13, 2014 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | |
| 14 | Win | 14–0 | Noe Bolanos | RTD | 2 (8), 3:00 | Sep 11, 2014 | The Joint, Paradise, Nevada, U.S. | |
| 13 | Win | 13–0 | Ronald Cruz | UD | 10 | Jun 27, 2014 | The Joint, Paradise, Nevada, U.S. | |
| 12 | Win | 12–0 | Raymond Charles | TKO | 1 (10), 2:52 | Apr 18, 2014 | Illusions Theater, San Antonio, Texas, U.S. | |
| 11 | Win | 11–0 | Peter Olouch | KO | 4 (8), 1:39 | Feb 10, 2014 | Cowboys Dancehall, San Antonio, Texas, U.S. | |
| 10 | Win | 10–0 | Gerardo Cuevas | RTD | 1 (8), 3:00 | Dec 13, 2013 | Fantasy Springs Resort Casino, Indio, California, U.S. | |
| 9 | Win | 9–0 | Emmanuel Lartie Lartey | UD | 8 | Oct 14, 2013 | BB&T Center, Sunrise, Florida, U.S. | |
| 8 | Win | 8–0 | Jesus Tavera | TKO | 1 (8), 2:33 | Sep 12, 2013 | MGM Grand Marquee Ballroom, Paradise, Nevada, U.S. | |
| 7 | Win | 7–0 | Eddie Cordova | KO | 1 (6), 2:13 | Jul 20, 2013 | Fantasy Springs Resort Casino, Indio, California, U.S. | |
| 6 | Win | 6–0 | Guillermo Ibarra | KO | 1 (6), 1:32 | Jun 1, 2013 | BB&T Center, Sunrise, Florida, U.S. | |
| 5 | Win | 5–0 | Brandon Hoskins | TKO | 1 (6), 2:35 | May 3, 2013 | Cosmopolitan of Las Vegas, Paradise, Nevada, U.S | |
| 4 | Win | 4–0 | Luis Torres | UD | 4 | Mar 2, 2013 | Our Lady of the Lake University Gym, San Antonio, Texas, U.S. | |
| 3 | Win | 3–0 | Nathan Butcher | TKO | 1 (4), 1:03 | Jan 26, 2013 | The Joint, Paradise, Nevada, U.S. | |
| 2 | Win | 2–0 | Richard Andrews | TKO | 3 (4), 0:44 | Dec 15, 2012 | Memorial Sports Arena, Los Angeles, California, U.S. | |
| 1 | Win | 1–0 | Jonathan Garcia | KO | 3 (4), 2:41 | Nov 9, 2012 | Fantasy Springs Resort Casino, Indio, California, U.S. | |
