| Year | Title | Role | Language | Notes |
| 2001 | Point de lendemain | Agnes | French | Short subject |
| 2002 | Duelles | Sabine | Episode: "Mauvaise conduite" |
| The Piano Player | Erika Nile | English | American title: The Target |
| Not For, or Against | A call girl | French | French title: Ni pour, ni contre (bien au contraire) |
| Mon Idole | Clara Broustal | English title: Whatever You Say |
| 2003 | Michel Vaillant | Julie Wood | |
| 2004 | Troy | Helen | English | |
| Wicker Park | Lisa | |
| Narco | La fille du night-club | French | |
| National Treasure | Abigail Chase | English | |
| 2005 | Joyeux Noël | Anna Sørensen | French, English, German | |
| Frankie | Frankie | French | |
| 2006 | Les Brigades du Tigre | Constance Radetsky | English title: The Tiger Brigades |
| Copying Beethoven | Anna Holtz | English | |
| 2007 | Goodbye Bafana | Gloria Gregory | |
| Days of Darkness | Véronica Star | French | French title: L'Âge des ténèbres |
| The Hunting Party | Mirjana | English | |
| National Treasure: Book of Secrets | Abigail Chase | |
| 2008 | Anything for Her | Lisa | French | |
| 2009 | Inglourious Basterds | Bridget von Hammersmark | English, French, German | |
| Mr. Nobody | Anna | English | |
| Farewell | Femme jogging | French | French title: L'Affaire Farewell |
| 2010 | Inhale | Diane Stanton | English | |
| Lily Sometimes | Clara | French | French title: Pieds nus sur les limaces |
| 2011 | Unknown | Gina | English | |
| Forces spéciales | Elsa | French | English title: Special Forces |
| 2012 | Farewell, My Queen | Queen Marie Antoinette | French title: Les adieux à la Reine |
| Un plan parfait | Isabelle | English title: A Perfect Plan / Fly Me to the Moon |
| 2013 | The Host | The Seeker/Lacey | English | |
| Me, Myself and Mum | Ingeborg | French | French title: Les Garçons et Guillaume, à table! |
| The Galapagos Affair: Satan Came to Eden | Margret Wittmer | English | Narration/Voice |
| 2014 | The Better Angels | Sarah Bush Lincoln | |
| 2015 | Fathers and Daughters | Elizabeth | |
| Disorder | Jessie | French | |
| Sky | Romy | English | |
| 2016 | The Infiltrator | Kathy Ertz | |
| 2017 | In the Fade | Katja Sekerci | German | German title: Aus dem Nichts |
| All That Divides Us | Julia Keller | French | |
| 2018 | JT LeRoy | Eva | English | |
| Welcome to Marwen | Deja Thoris | |
| 2019 | The Operative | Rachel | |
| QT8: The First Eight | Herself | Documentary film |
| 2022 | The 355 | Marie Schmidt | |
| Out of the Blue | Marilyn | |
| Marlowe | Clare Cavendish | |
| 2023 | Visions | Estelle | French | |
| Joika | Tatiyana Volkova | English | Biopic drama |
| 2024 | The Shrouds | Three roles | |
| Longing | Alice | |
