| No. | Result | Record | Opponent | Type | Round, time | Date | Location | Notes |
| 49 | Win | 44–4–1 | Tyrrell Anthony Herndon | TKO | 7 (10), 2:16 | Jun 27, 2025 | Charles Koch Arena, Wichita, Kansas, U.S. | |
| 48 | Loss | 43–4–1 | Zhilei Zhang | TKO | 5 (12), 1:51 | Jun 1, 2024 | Kingdom Arena, Riyadh, Saudi Arabia | |
| 47 | Loss | 43–3–1 | Joseph Parker | UD | 12 | Dec 23, 2023 | Kingdom Arena, Riyadh, Saudi Arabia | For WBO Inter-Continental and vacant WBC International heavyweight titles |
| 46 | Win | 43–2–1 | Robert Helenius | KO | 1 (12), 2:57 | Oct 15, 2022 | Barclays Center, New York City, New York, U.S. | |
| 45 | Loss | 42–2–1 | Tyson Fury | KO | 11 (12), 1:10 | Oct 9, 2021 | T-Mobile Arena, Paradise, Nevada, U.S. | For WBC and The Ring heavyweight titles |
| 44 | Loss | 42–1–1 | Tyson Fury | TKO | 7 (12), 1:39 | Feb 22, 2020 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Lost WBC heavyweight title;For vacant The Ring heavyweight title |
| 43 | Win | 42–0–1 | Luis Ortiz | KO | 7 (12), 2:51 | Nov 23, 2019 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Retained WBC heavyweight title |
| 42 | Win | 41–0–1 | Dominic Breazeale | KO | 1 (12), 2:17 | May 18, 2019 | Barclays Center, New York City, New York, U.S. | Retained WBC heavyweight title |
| 41 | Draw | 40–0–1 | Tyson Fury | SD | 12 | Dec 1, 2018 | Staples Center, Los Angeles, California, U.S. | Retained WBC heavyweight title |
| 40 | Win | 40–0 | Luis Ortiz | TKO | 10 (12), 2:05 | Mar 3, 2018 | Barclays Center, New York City, New York, U.S. | Retained WBC heavyweight title |
| 39 | Win | 39–0 | Bermane Stiverne | KO | 1 (12), 2:59 | Nov 4, 2017 | Barclays Center, New York City, New York, U.S. | Retained WBC heavyweight title |
| 38 | Win | 38–0 | Gerald Washington | TKO | 5 (12), 1:45 | Feb 25, 2017 | Legacy Arena, Birmingham, Alabama, U.S. | Retained WBC heavyweight title |
| 37 | Win | 37–0 | Chris Arreola | RTD | 8 (12), 3:00 | Jul 16, 2016 | Legacy Arena, Birmingham, Alabama, U.S. | Retained WBC heavyweight title |
| 36 | Win | 36–0 | Artur Szpilka | KO | 9 (12), 2:24 | Jan 16, 2016 | Barclays Center, New York City, New York, U.S. | Retained WBC heavyweight title |
| 35 | Win | 35–0 | Johann Duhaupas | TKO | 11 (12), 0:55 | Sep 26, 2015 | Legacy Arena, Birmingham, Alabama, U.S. | Retained WBC heavyweight title |
| 34 | Win | 34–0 | Éric Molina | KO | 9 (12), 1:03 | Jun 13, 2015 | Bartow Arena, Birmingham, Alabama, U.S. | Retained WBC heavyweight title |
| 33 | Win | 33–0 | Bermane Stiverne | UD | 12 | Jan 17, 2015 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Won WBC heavyweight title |
| 32 | Win | 32–0 | Jason Gavern | RTD | 4 (10), 3:00 | Aug 16, 2014 | StubHub Center, Carson, California, U.S. | |
| 31 | Win | 31–0 | Malik Scott | KO | 1 (12), 1:36 | Mar 15, 2014 | Coliseo Rubén Rodríguez, Bayamón, Puerto Rico | |
| 30 | Win | 30–0 | Nicolai Firtha | KO | 4 (10), 1:26 | Oct 26, 2013 | Boardwalk Hall, Atlantic City, New Jersey, U.S. | Retained WBC Continental Americas heavyweight title |
| 29 | Win | 29–0 | Siarhei Liakhovich | KO | 1 (10), 1:43 | Aug 9, 2013 | Fantasy Springs Resort Casino, Indio, California, U.S. | Retained WBC Continental Americas heavyweight title |
| 28 | Win | 28–0 | Audley Harrison | TKO | 1 (12), 1:10 | Apr 27, 2013 | Motorpoint Arena, Sheffield, England | |
| 27 | Win | 27–0 | Matthew Greer | TKO | 2 (8), 1:16 | Jan 19, 2013 | Centro de Convenciones, Villahermosa, Mexico | |
| 26 | Win | 26–0 | Kelvin Price | KO | 3 (10), 0:51 | Dec 15, 2012 | Memorial Sports Arena, Los Angeles, California, U.S. | Won vacant WBC Continental Americas heavyweight title |
| 25 | Win | 25–0 | Damon McCreary | KO | 2 (10), 0:55 | Sep 8, 2012 | The Hangar, Costa Mesa, California, U.S. | |
| 24 | Win | 24–0 | Kertson Manswell | TKO | 1 (10), 2:10 | Aug 4, 2012 | Civic Center Expo Hall, Mobile, Alabama, U.S. | |
| 23 | Win | 23–0 | Owen Beck | RTD | 3 (8), 3:00 | Jun 23, 2012 | Killer Buzz Arena, Tuscaloosa, Alabama, U.S. | |
| 22 | Win | 22–0 | Jesse Oltmanns | TKO | 1 (8), 0:26 | May 26, 2012 | Oasis Hotel Complex, Cancún, Mexico | |
| 21 | Win | 21–0 | Marlon Hayes | TKO | 4 (8), 3:00 | Feb 25, 2012 | Scottrade Center, St. Louis, Missouri, U.S. | |
| 20 | Win | 20–0 | David Long | KO | 1 (8), 1:17 | Nov 26, 2011 | Bank Arena, Cincinnati, Ohio, U.S. | |
| 19 | Win | 19–0 | Daniel Cota | KO | 3 (8), 2:55 | Nov 5, 2011 | Centro de Convenciones, Cancún, Mexico | |
| 18 | Win | 18–0 | Dominique Alexander | TKO | 2 (6), 2:02 | Aug 27, 2011 | Water Oaks Farm Arena, Tuscaloosa, Alabama, U.S. | |
| 17 | Win | 17–0 | Damon Reed | KO | 2 (6), 1:59 | Jun 18, 2011 | Tuscaloosa Amphitheater, Tuscaloosa, Alabama, U.S. | |
| 16 | Win | 16–0 | Reggie Pena | TKO | 1 (6), 2:03 | May 6, 2011 | Fantasy Springs Resort Casino, Indio, California, U.S. | |
| 15 | Win | 15–0 | DeAndrey Abron | TKO | 2 (6), 1:23 | Feb 19, 2011 | Shelton State Community College, Tuscaloosa, Alabama, U.S. | |
| 14 | Win | 14–0 | Danny Sheehan | KO | 1 (6), 1:48 | Dec 2, 2010 | Hilton Towers Ballroom, Lafayette, Louisiana, U.S. | |
| 13 | Win | 13–0 | Harold Sconiers | TKO | 4 (6), 1:09 | Oct 15, 2010 | Fantasy Springs Resort Casino, Indio, California, U.S. | |
| 12 | Win | 12–0 | Shannon Caudle | KO | 1 (6), 1:04 | Sep 25, 2010 | Fitzgeralds Casino and Hotel, Tunica Resorts, Mississippi, U.S. | |
| 11 | Win | 11–0 | Dustin Nichols | TKO | 1 (6), 3:00 | Jul 3, 2010 | Club Palace, Hattiesburg, Mississippi, U.S. | |
| 10 | Win | 10–0 | Alvaro Morales | TKO | 3 (6), 1:23 | Apr 30, 2010 | Tropicana Las Vegas, Paradise, Nevada, U.S. | |
| 9 | Win | 9–0 | Ty Cobb | KO | 1 (6), 0:33 | Apr 2, 2010 | The Joint, Paradise, Nevada, U.S. | |
| 8 | Win | 8–0 | Jerry Vaughn | KO | 1 (6), 1:02 | Nov 28, 2009 | Duke Energy Convention Center, Cincinnati, Ohio, U.S. | |
| 7 | Win | 7–0 | Travis Allen | TKO | 1 (4), 1:30 | Aug 14, 2009 | Desert Diamond Casino, Tucson, Arizona, U.S. | |
| 6 | Win | 6–0 | Kelsey Arnold | KO | 1 (4), 1:13 | Jun 26, 2009 | Desert Diamond Casino, Tucson, Arizona, U.S. | |
| 5 | Win | 5–0 | Charles Brown | KO | 1 (6), 0:55 | May 23, 2009 | Duke Energy Convention Center, Cincinnati, Ohio, U.S. | |
| 4 | Win | 4–0 | Joseph Rabotte | KO | 1 (4), 2:33 | Apr 24, 2009 | UIC Pavilion, Chicago, Illinois, U.S. | |
| 3 | Win | 3–0 | Richard Greene Jr. | RTD | 1 (4), 0:11 | Mar 14, 2009 | Duke Energy Convention Center, Cincinnati, Ohio, U.S. | |
| 2 | Win | 2–0 | Shannon Gray | TKO | 1 (4), 2:12 | Mar 6, 2009 | James M. Trotter Convention Center, Columbus, Mississippi, U.S. | |
| 1 | Win | 1–0 | Ethan Cox | TKO | 2 (4), 2:54 | Nov 15, 2008 | Memorial Gymnasium, Nashville, Tennessee, U.S. | |