| Character | Japanese | English |
| Main characters |
| Tanjiro Kamado (竈門 炭治郎, Kamado Tanjirō) | Natsuki HanaeSatomi Satō (child) | Zach AguilarAllegra Clark (child) |
| Nezuko Kamado (竈門 禰豆子, Kamado Nezuko) | Akari Kitō | Abby Trott |
| Zenitsu Agatsuma (我妻 善逸, Agatsuma Zen'itsu) | Hiro Shimono | Aleks Le |
| Inosuke Hashibira (嘴平 伊之助, Hashibira Inosuke) | Yoshitsugu Matsuoka | Bryce Papenbrook |
| Kanao Tsuyuri (栗花落 カナヲ, Tsuyuri Kanao) | Reina Ueda | Brianna Knickerbocker |
| Genya Shinazugawa (不死川 玄弥, Shinazugawa Gen'ya) | Nobuhiko Okamoto | Zeno Robinson |
| Secondary characters |
| Giyu Tomioka (冨岡 義勇, Tomioka Giyū) | Takahiro Sakurai | Johnny Yong Bosch |
| Shinobu Kocho (胡蝶 しのぶ, Kochō Shinobu) | Saori Hayami | Erika Harlacher |
| Kyojuro Rengoku (煉獄 杏寿郎, Rengoku Kyōjurō) | Satoshi HinoMariya Ise (child) | Mark WhittenRyan Bartley (child) |
| Tengen Uzui (宇髄 天元, Uzui Tengen) | Katsuyuki Konishi | Ray Chase |
| Mitsuri Kanroji (甘露寺 蜜璃, Kanroji Mitsuri) | Kana Hanazawa | Kira Buckland |
| Muichiro Tokito (時透 無一郎, Tokitō Muichirō) | Kengo Kawanishi | Griffin Burns |
| Sanemi Shinazugawa (不死川 実弥, Shinazugawa Sanemi) | Tomokazu Seki | Kaiji Tang |
| Obanai Iguro (伊黒 小芭内, Iguro Obanai) | Kenichi Suzumura | Erik Scott Kimerer |
| Gyomei Himejima (悲鳴嶼 行冥, Himejima Gyōmei) | Tomokazu Sugita | Crispin Freeman |
| Supporting characters |
| Kagaya Ubuyashiki (産屋敷 耀哉, Ubuyashiki Kagaya) | Toshiyuki Morikawa | Matthew Mercer |
| Amane Ubuyashiki (産屋敷 あまね, Ubuyashiki Amane) | Rina Satō | Suzie Yeung |
| Hinaki Ubuyashiki (産屋敷 ひなき, Ubuyashiki Hinaki) | Yumiri Hanamori | Kimberly Woods |
| Nichika Ubuyashiki (産屋敷 にちか, Ubuyashiki Nichika) | Ari Ozawa | Brianna Knickerbocker |
| Kiriya Ubuyashiki (産屋敷 輝利哉, Ubuyashiki Kiriya) | Aoi Yūki | Christine Marie Cabanos |
| Kanata Ubuyashiki (産屋敷 かなた, Ubuyashiki Kanata) | Shiori Izawa | Mela Lee |
| Muzan Kibutsuji (鬼舞辻 無惨, Kibutsuji Muzan) | Toshihiko Seki | Greg Chun |
| Nakime (鳴女, Nakime) | Marina Inoue | Amber Lee Connors |
| Kaigaku (獪岳, Kaigaku) | Yoshimasa Hosoya | Alejandro Saab |
| Kokushibo / Upper Rank 1 (黒死牟, Kokushibō) | Ryōtarō Okiayu | Jonah Scott |
| Doma / Upper Rank 2 (童磨, Dōma) | Mamoru Miyano | Stephen Fu |
| Akaza / Upper Rank 3 (猗窩座) | Akira Ishida | Lucien Dodge |
| Hantengu / Upper Rank 4 (半天狗) | Toshio Furukawa (Hantengu and Urami)Yūichirō Umehara (Sekido)Kaito Ishikawa (Karaku)Shunsuke Takeuchi (Urogi)Soma Saito (Aizetsu)Koichi Yamadera (Zohakuten) | Christopher Corey Smith (Hantengu and Urami)Yong Yea (Sekido)Caleb Yen (Karaku)Chris Hackney (Urogi)Brian Timothy Anderson (Aizetsu)Ben Balmaceda (Zohakuten) |
| Gyokko / Upper Rank 5 (玉壼, Gyokko) | Kohsuke Toriumi | Brent Mukai |
| Daki / Upper Rank 6 (堕姫, Daki) | Miyuki Sawashiro | Erica Lindbeck |
| Gyutaro / Upper Rank 6 (妓夫太郎, Gyūtarō) | Ryōta Ōsaka | Brandon McInnis |
| Enmu / Lower Rank 1 (魘夢, Enmu) | Daisuke Hirakawa | Landon McDonald |
| Rokuro / Lower Rank 2 (轆轤, Rokuro) | Taiten Kusunoki | Ray Chase |
| Wakuraba / Lower Rank 3 (病葉, Wakuraba) | Sōichirō Hoshi | Stefan Martello |
| Mukago / Lower Rank 4 (零余子, Mukago) | Kana Ueda | Kira Buckland |
| Rui / Lower Rank 5 (累, Rui) | Koki Uchiyama | Billy Kametz |
| Kamanue / Lower Rank 6 (釜鵺, Kamanue) | KENN | Alan Lee |
| Kyogai (響凱, Kyōgai) | Junichi Suwabe | Steve Blum |
| Minor characters |
| Spider Demon (Mother) (蜘蛛鬼「母」, Kumo Oni: Haha) | Ami Koshimizu | Allegra Clark |
| Spider Demon (Father) (蜘蛛鬼「父」, Kumo Oni: Chichi) | Tetsu Inada | Kellen Goff |
| Spider Demon (Brother) (蜘蛛鬼「兄」, Kumo Oni: Ani) | Showtaro Morikubo | Derek Stephen Prince |
| Spider Demon (Sister) (蜘蛛鬼「姉」, Kumo Oni: Ane) | Ryoko Shiraishi | Erica Lindbeck |
| Yahaba (矢琶羽, Yahaba) | Jun Fukuyama | Xander Mobus |
| Susamaru (朱紗丸, Susamaru) | Mikako Komatsu | Sarah Anne Williams |
| Sakonji Urokodaki (鱗滝 左近次, Urokodaki Sakonji) | Hōchū Ōtsuka | Brook Chalmers |
