| Res. | Record | Opponent | Method | Event | Date | Round | Time | Location | Notes |
| Loss | 22–3 (1) | Stipe Miocic | Decision (unanimous) | UFC 252 | August 15, 2020 | 5 | 5:00 | Las Vegas, Nevada, United States | For the UFC Heavyweight Championship. |
| Loss | 22–2 (1) | Stipe Miocic | TKO (punches) | UFC 241 | August 17, 2019 | 4 | 4:09 | Anaheim, California, United States | Lost the UFC Heavyweight Championship. |
| Win | 22–1 (1) | Derrick Lewis | Submission (rear-naked choke) | UFC 230 | November 3, 2018 | 2 | 2:14 | New York City, New York, United States | Defended the UFC Heavyweight Championship. |
| Win | 21–1 (1) | Stipe Miocic | KO (punches) | UFC 226 | July 7, 2018 | 1 | 4:33 | Las Vegas, Nevada, United States | Won the UFC Heavyweight Championship. Performance of the Night. |
| Win | 20–1 (1) | Volkan Oezdemir | TKO (punches) | UFC 220 | January 20, 2018 | 2 | 2:00 | Boston, Massachusetts, United States | Defended the UFC Light Heavyweight Championship. Performance of the Night. Later vacated the title. |
| NC | 19–1 (1) | Jon Jones | NC (overturned by CSAC) | UFC 214 | July 29, 2017 | 3 | 3:01 | Anaheim, California, United States | Retained the UFC Light Heavyweight Championship. Originally a KO (head kick and punches) loss; overturned to a no contest by the CSAC after Jones tested positive for a turinabol metabolite. Cormier was subsequently reinstated as champion. |
| Win | 19–1 | Anthony Johnson | Submission (rear-naked choke) | UFC 210 | April 8, 2017 | 2 | 3:37 | Buffalo, New York, United States | Defended the UFC Light Heavyweight Championship. |
| Win | 18–1 | Anderson Silva | Decision (unanimous) | UFC 200 | July 9, 2016 | 3 | 5:00 | Las Vegas, Nevada, United States | Non-title bout. |
| Win | 17–1 | Alexander Gustafsson | Decision (split) | UFC 192 | October 3, 2015 | 5 | 5:00 | Houston, Texas, United States | Defended the UFC Light Heavyweight Championship. Fight of the Night. |
| Win | 16–1 | Anthony Johnson | Submission (rear-naked choke) | UFC 187 | May 23, 2015 | 3 | 2:39 | Las Vegas, Nevada, United States | Won the vacant UFC Light Heavyweight Championship. Performance of the Night. |
| Loss | 15–1 | Jon Jones | Decision (unanimous) | UFC 182 | January 3, 2015 | 5 | 5:00 | Las Vegas, Nevada, United States | For the UFC Light Heavyweight Championship. Fight of the Night. |
| Win | 15–0 | Dan Henderson | Technical Submission (rear-naked choke) | UFC 173 | May 24, 2014 | 3 | 3:53 | Las Vegas, Nevada, United States | |
| Win | 14–0 | Patrick Cummins | TKO (punches) | UFC 170 | February 22, 2014 | 1 | 1:19 | Las Vegas, Nevada, United States | Light Heavyweight debut. |
| Win | 13–0 | Roy Nelson | Decision (unanimous) | UFC 166 | October 19, 2013 | 3 | 5:00 | Houston, Texas, United States | |
| Win | 12–0 | Frank Mir | Decision (unanimous) | UFC on Fox: Henderson vs. Melendez | April 20, 2013 | 3 | 5:00 | San Jose, California, United States | |
| Win | 11–0 | Dion Staring | TKO (punches) | Strikeforce: Marquardt vs. Saffiedine | January 12, 2013 | 2 | 4:02 | Oklahoma City, Oklahoma, United States | |
| Win | 10–0 | Josh Barnett | Decision (unanimous) | Strikeforce: Barnett vs. Cormier | May 19, 2012 | 5 | 5:00 | San Jose, California, United States | Won the Strikeforce Heavyweight Grand Prix Tournament. |
| Win | 9–0 | Antônio Silva | KO (punches) | Strikeforce: Barnett vs. Kharitonov | September 10, 2011 | 1 | 3:56 | Cincinnati, Ohio, United States | Strikeforce Heavyweight Grand Prix Semi-Final. |
| Win | 8–0 | Jeff Monson | Decision (unanimous) | Strikeforce: Overeem vs. Werdum | June 18, 2011 | 3 | 5:00 | Dallas, Texas, United States | Strikeforce Heavyweight Grand Prix reserve bout. |
| Win | 7–0 | Devin Cole | Decision (unanimous) | Strikeforce Challengers: Woodley vs. Saffiedine | January 7, 2011 | 3 | 5:00 | Nashville, Tennessee, United States | |
| Win | 6–0 | Soa Palelei | TKO (submission to punches) | XMMA 3 | November 5, 2010 | 1 | 2:23 | Sydney, Australia | Defended the XMMA Heavyweight Championship. |
| Win | 5–0 | Jason Riley | TKO (submission to punches) | Strikeforce: Houston | August 21, 2010 | 1 | 1:02 | Houston, Texas, United States | |
| Win | 4–0 | Tony Johnson | Submission (rear-naked choke) | KOTC: Imminent Danger | August 13, 2010 | 1 | 2:27 | Mescalero, New Mexico, United States | Won the KOTC Heavyweight Championship. |
| Win | 3–0 | Lucas Browne | TKO (punches) | XMMA 2 | July 31, 2010 | 1 | 4:35 | Sydney, Australia | Won the XMMA Heavyweight Championship. |
| Win | 2–0 | John Devine | KO (punch) | Strikeforce Challengers: Johnson vs. Mahe | March 26, 2010 | 1 | 1:19 | Fresno, California, United States | |
| Win | 1–0 | Gary Frazier | TKO (punches) | Strikeforce Challengers: Kennedy vs. Cummings | September 25, 2009 | 2 | 3:39 | Bixby, Oklahoma, United States | |