| Res. | Record | Opponent | Method | Event | Date | Round | Time | Location | Notes |
| Win | 19–5 (1) | Rizvan Kuniev | Decision (split) | UFC on ABC: Hill vs. Rountree Jr. | June 21, 2025 | 3 | 5:00 | Baku, Azerbaijan | |
| Loss | 18–5 (1) | Tom Aspinall | KO (punches) | UFC 304 | July 27, 2024 | 1 | 1:00 | Manchester, England | For the interim UFC Heavyweight Championship. |
| Win | 18–4 (1) | Jailton Almeida | KO (punches) | UFC 299 | March 9, 2024 | 2 | 0:36 | Miami, Florida, United States | Performance of the Night. |
| Loss | 17–4 (1) | Sergei Pavlovich | TKO (punches) | UFC Fight Night: Pavlovich vs. Blaydes | April 22, 2023 | 1 | 3:08 | Las Vegas, Nevada, United States | |
| Win | 17–3 (1) | Tom Aspinall | TKO (knee injury) | UFC Fight Night: Blaydes vs. Aspinall | July 23, 2022 | 1 | 0:15 | London, England | |
| Win | 16–3 (1) | Chris Daukaus | TKO (punches) | UFC on ESPN: Blaydes vs. Daukaus | March 26, 2022 | 2 | 0:17 | Columbus, Ohio, United States | Performance of the Night. |
| Win | 15–3 (1) | Jairzinho Rozenstruik | Decision (unanimous) | UFC 266 | September 25, 2021 | 3 | 5:00 | Las Vegas, Nevada, United States | |
| Loss | 14–3 (1) | Derrick Lewis | KO (punch) | UFC Fight Night: Blaydes vs. Lewis | February 20, 2021 | 2 | 1:26 | Las Vegas, Nevada, United States | |
| Win | 14–2 (1) | Alexander Volkov | Decision (unanimous) | UFC on ESPN: Blaydes vs. Volkov | June 20, 2020 | 5 | 5:00 | Las Vegas, Nevada, United States | |
| Win | 13–2 (1) | Junior dos Santos | TKO (punches) | UFC Fight Night: Blaydes vs. dos Santos | January 25, 2020 | 2 | 1:06 | Raleigh, North Carolina, United States | |
| Win | 12–2 (1) | Shamil Abdurakhimov | TKO (elbow and punch) | UFC 242 | September 7, 2019 | 2 | 2:22 | Abu Dhabi, United Arab Emirates | |
| Win | 11–2 (1) | Justin Willis | Decision (unanimous) | UFC Fight Night: Thompson vs. Pettis | March 23, 2019 | 3 | 5:00 | Nashville, Tennessee, United States | |
| Loss | 10–2 (1) | Francis Ngannou | TKO (punches) | UFC Fight Night: Blaydes vs. Ngannou 2 | November 24, 2018 | 1 | 0:45 | Beijing, China | |
| Win | 10–1 (1) | Alistair Overeem | TKO (elbows) | UFC 225 | June 9, 2018 | 3 | 2:56 | Chicago, Illinois, United States | Performance of the Night. |
| Win | 9–1 (1) | Mark Hunt | Decision (unanimous) | UFC 221 | February 11, 2018 | 3 | 5:00 | Perth, Australia | |
| Win | 8–1 (1) | Aleksei Oleinik | TKO (doctor stoppage) | UFC 217 | November 4, 2017 | 2 | 1:56 | New York City, New York, United States | |
| Win | 7–1 (1) | Daniel Omielańczuk | Decision (unanimous) | UFC 213 | July 8, 2017 | 3 | 5:00 | Las Vegas, Nevada, United States | |
| NC | 6–1 (1) | Adam Milstead | NC (overturned) | UFC Fight Night: Bermudez vs. The Korean Zombie | February 4, 2017 | 2 | 0:59 | Houston, Texas, United States | Originally a TKO (knee injury) win for Blaydes; overturned after he tested positive for marijuana. |
| Win | 6–1 | Cody East | TKO (elbows) | UFC Fight Night: Lineker vs. Dodson | October 1, 2016 | 2 | 2:02 | Portland, Oregon, United States | Performance of the Night. |
| Loss | 5–1 | Francis Ngannou | TKO (doctor stoppage) | UFC Fight Night: Rothwell vs. dos Santos | April 10, 2016 | 2 | 5:00 | Zagreb, Croatia | |
| Win | 5–0 | Luis Cortez | TKO (punches) | RFA 35 | February 19, 2016 | 3 | 0:41 | Orem, Utah, United States | |
| Win | 4–0 | Allen Crowder | TKO (punches) | Battle in the South 10 | April 10, 2015 | 2 | N/A | Wilmington, North Carolina, United States | |
| Win | 3–0 | Brad Faylor | TKO (punches) | Sugar Creek Showdown 23 | November 15, 2014 | 2 | 0:45 | Hinton, Oklahoma, United States | |
| Win | 2–0 | William Baptiste | TKO (punches) | XFO 53 | October 11, 2014 | 1 | 2:14 | Chicago, Illinois, United States | |
| Win | 1–0 | Lorenzo Hood | TKO (doctor stoppage) | XFO 51 | May 31, 2014 | 1 | 1:42 | Chicago, Illinois, United States | Heavyweight debut. |