| Year | Association | Category | Work | Result | Ref. |
| 1995 | American Comedy Awards | Funniest Supporting Female Performer in a Television Series | Friends | Nominated | |
| People's Choice Awards | Favorite Performer in a New Television Program | Won | |
| 1996 | Screen Actors Guild Awards | Outstanding Performance by an Ensemble in a Comedy Series | Won | |
| 1997 | Nickelodeon Kids' Choice Awards | Favorite Television Actress | Nominated | |
| 1998 | Blockbuster Entertainment Awards | Favorite Actress – Horror | Scream 2 | Nominated | |
| Saturn Awards | Best Supporting Actress | Nominated | |
| 1999 | American Comedy Awards | Funniest Supporting Female Performer in a Television Series | Friends | Nominated | |
| Screen Actors Guild Awards | Outstanding Performance by an Ensemble in a Comedy Series | Nominated | |
| 2000 | Nickelodeon Kids' Choice Awards | Favorite Television Friends (shared with Jennifer Aniston & Lisa Kudrow) | Nominated | |
| Screen Actors Guild Awards | Outstanding Performance by an Ensemble in a Comedy Series | Nominated | |
| Teen Choice Awards | Choice Movie – Chemistry (shared with David Arquette) | Scream 3 | Won | |
| TV Guide Awards | Editor's Choice Award | Friends | Won | |
| 2001 | Blockbuster Entertainment Awards | Favorite Actress – Horror (Internet Only) | Scream 3 | Nominated | |
| Screen Actors Guild Awards | Outstanding Performance by an Ensemble in a Comedy Series | Friends | Nominated | |
| The Stinkers Bad Movie Awards | Most Annoying Fake Accent – Female | 3000 Miles to Graceland | Nominated | |
| Worst Supporting Actress | Nominated | |
| 2002 | Golden Raspberry Awards | Worst Supporting Actress | Nominated | |
| Worst Screen Couple (shared with Kurt Russell) | Nominated | |
| Screen Actors Guild Awards | Outstanding Performance by an Ensemble in a Comedy Series | Friends | Nominated | |
| Teen Choice Awards | Choice TV Actress – Comedy | Nominated | |
| 2003 | Screen Actors Guild Awards | Outstanding Performance by an Ensemble in a Comedy Series | Nominated | |
| Teen Choice Awards | Choice TV Actress – Comedy | Nominated | |
| 2004 | Screen Actors Guild Awards | Outstanding Performance by an Ensemble in a Comedy Series | Nominated | |
| 2005 | Teen Choice Awards | Choice Movie – Hissy Fit | The Longest Yard | Nominated | |
| 2006 | The Stinkers Bad Movie Awards | Worst Supporting Actress | Zoom | Nominated | |
| TV Land Awards | Most Wonderful Wedding (shared with Matthew Perry) | Friends | Nominated | |
| 2007 | TV Land Awards | Break Up That Was So Bad It Was Good (shared with Michael J. Fox) | Family Ties | Nominated | |
| 2010 | Gold Derby Awards | Comedy Lead Actress | Cougar Town | Won | |
| Golden Globe Awards | Best Actress in a Television Series – Comedy or Musical | Nominated | |
| The Streamy Awards | Best Guest Star in a Web Series | Web Therapy | Nominated | |
| Women's Image Network Awards | Actress Comedy Series | Cougar Town | Nominated | |
| 2011 | Critics' Choice Television Awards | Best Actress in a Comedy Series | Nominated | |
| Gold Derby Awards | Comedy Lead Actress | Nominated | |
| People's Choice Awards | Favorite Television Comedy Actress | Nominated | |
| 2012 | People's Choice Awards | Favorite Television Comedy Actress | Nominated | |
| 2014 | People's Choice Awards | Favorite Cable Television Actress | Nominated | |
| 2015 | People's Choice Awards | Favorite Cable Television Actress | Nominated | |
| 2017 | Daytime Emmy Awards | Outstanding Game Show | Celebrity Name Game | Nominated | |
| 2021 | Primetime Emmy Awards | Outstanding Variety Special (Pre-Recorded) | Friends: The Reunion | Nominated | |
| 2022 | Saturn Awards | Best Actress in a Network or Cable Television Series | Shining Vale | Nominated | |
| 2023 | MTV Movie & TV Awards | Best Fight (shared with Ghostface) | Scream VI | Won | |