| Res. | Record | Opponent | Method | Event | Date | Round | Time | Location | Notes |
| NC | 13–2 (1) | Tom Aspinall | NC (accidental eye poke) | UFC 321 | October 25, 2025 | 1 | 4:35 | Abu Dhabi, United Arab Emirates | For the UFC Heavyweight Championship. Accidental eye poke rendered Aspinall unable to continue. |
| Win | 13–2 | Alexander Volkov | Decision (split) | UFC 310 | December 7, 2024 | 3 | 5:00 | Las Vegas, Nevada, United States | |
| Win | 12–2 | Serghei Spivac | TKO (punches) | UFC Fight Night: Gane vs. Spivac | September 2, 2023 | 2 | 3:44 | Paris, France | Performance of the Night. |
| Loss | 11–2 | Jon Jones | Submission (guillotine choke) | UFC 285 | March 4, 2023 | 1 | 2:04 | Las Vegas, Nevada, United States | For the vacant UFC Heavyweight Championship. |
| Win | 11–1 | Tai Tuivasa | KO (punches) | UFC Fight Night: Gane vs. Tuivasa | September 3, 2022 | 3 | 4:23 | Paris, France | Fight of the Night. |
| Loss | 10–1 | Francis Ngannou | Decision (unanimous) | UFC 270 | January 22, 2022 | 5 | 5:00 | Anaheim, California, United States | For the UFC Heavyweight Championship. |
| Win | 10–0 | Derrick Lewis | TKO (punches) | UFC 265 | August 7, 2021 | 3 | 4:11 | Houston, Texas, United States | Won the interim UFC Heavyweight Championship. Performance of the Night. |
| Win | 9–0 | Alexander Volkov | Decision (unanimous) | UFC Fight Night: Gane vs. Volkov | June 26, 2021 | 5 | 5:00 | Las Vegas, Nevada, United States | |
| Win | 8–0 | Jairzinho Rozenstruik | Decision (unanimous) | UFC Fight Night: Rozenstruik vs. Gane | February 27, 2021 | 5 | 5:00 | Las Vegas, Nevada, United States | |
| Win | 7–0 | Junior dos Santos | TKO (elbow) | UFC 256 | December 12, 2020 | 2 | 2:34 | Las Vegas, Nevada, United States | |
| Win | 6–0 | Tanner Boser | Decision (unanimous) | UFC Fight Night: Edgar vs. The Korean Zombie | December 21, 2019 | 3 | 5:00 | Busan, South Korea | |
| Win | 5–0 | Don'Tale Mayes | Submission (heel hook) | UFC Fight Night: Maia vs. Askren | October 26, 2019 | 3 | 4:46 | Kallang, Singapore | Performance of the Night. |
| Win | 4–0 | Raphael Pessoa | Submission (arm-triangle choke) | UFC Fight Night: Shevchenko vs. Carmouche 2 | August 10, 2019 | 1 | 4:12 | Montevideo, Uruguay | |
| Win | 3–0 | Roggers Souza | TKO (punches) | TKO 48 | May 24, 2019 | 1 | 4:26 | Gatineau, Quebec, Canada | Defended the TKO Heavyweight Championship. |
| Win | 2–0 | Adam Dyczka | TKO (punches) | TKO 44 | September 21, 2018 | 2 | 4:57 | Québec City, Quebec, Canada | Defended the TKO Heavyweight Championship. |
| Win | 1–0 | Bobby Sullivan | Submission (guillotine choke) | TKO Fight Night 1 | August 2, 2018 | 1 | 1:42 | Montreal, Quebec, Canada | Heavyweight debut. Won the vacant TKO Heavyweight Championship. |