| Res. | Record | Opponent | Method | Event | Date | Round | Time | Location | Notes |
| Loss | 21–9 | Tito Ortiz | KO (punches) | Golden Boy Promotions: Liddell vs. Ortiz 3 | November 24, 2018 | 1 | 4:24 | Inglewood, California, United States | Heavyweight bout. |
| Loss | 21–8 | Rich Franklin | KO (punch) | UFC 115 | June 12, 2010 | 1 | 4:55 | Vancouver, British Columbia, Canada | |
| Loss | 21–7 | Maurício Rua | TKO (punches) | UFC 97 | April 18, 2009 | 1 | 4:28 | Montreal, Quebec, Canada | |
| Loss | 21–6 | Rashad Evans | KO (punch) | UFC 88 | September 6, 2008 | 2 | 1:51 | Atlanta, Georgia, United States | |
| Win | 21–5 | Wanderlei Silva | Decision (unanimous) | UFC 79 | December 29, 2007 | 3 | 5:00 | Las Vegas, Nevada, United States | Fight of the Night. |
| Loss | 20–5 | Keith Jardine | Decision (split) | UFC 76 | September 22, 2007 | 3 | 5:00 | Anaheim, California, United States | |
| Loss | 20–4 | Quinton Jackson | KO (punches) | UFC 71 | May 26, 2007 | 1 | 1:53 | Las Vegas, Nevada, United States | Lost the UFC Light Heavyweight Championship. |
| Win | 20–3 | Tito Ortiz | TKO (punches) | UFC 66 | December 30, 2006 | 3 | 3:59 | Las Vegas, Nevada, United States | Defended the UFC Light Heavyweight Championship. Fight of the Night. |
| Win | 19–3 | Renato Sobral | TKO (punches) | UFC 62 | August 26, 2006 | 1 | 1:35 | Las Vegas, Nevada, United States | Defended the UFC Light Heavyweight Championship. Knockout of the Night. |
| Win | 18–3 | Randy Couture | KO (punch) | UFC 57 | February 4, 2006 | 2 | 1:28 | Las Vegas, Nevada, United States | Defended the UFC Light Heavyweight Championship. |
| Win | 17–3 | Jeremy Horn | TKO (retirement) | UFC 54 | August 20, 2005 | 4 | 2:46 | Las Vegas, Nevada, United States | Defended the UFC Light Heavyweight Championship. |
| Win | 16–3 | Randy Couture | KO (punches) | UFC 52 | April 16, 2005 | 1 | 2:06 | Las Vegas, Nevada, United States | Won the UFC Light Heavyweight Championship. Knockout of the Year (2005). |
| Win | 15–3 | Vernon White | KO (punch) | UFC 49 | August 21, 2004 | 1 | 4:05 | Las Vegas, Nevada, United States | |
| Win | 14–3 | Tito Ortiz | KO (punches) | UFC 47 | April 2, 2004 | 2 | 0:38 | Las Vegas, Nevada, United States | |
| Loss | 13–3 | Quinton Jackson | TKO (corner stoppage) | Pride Final Conflict 2003 | November 9, 2003 | 2 | 3:10 | Tokyo, Japan | 2003 Pride Middleweight Grand Prix Semifinals. |
| Win | 13–2 | Alistair Overeem | KO (punches) | Pride Total Elimination 2003 | August 10, 2003 | 1 | 3:09 | Saitama, Saitama, Japan | 2003 Pride Middleweight Grand Prix Quarterfinals. |
| Loss | 12–2 | Randy Couture | TKO (punches) | UFC 43 | June 6, 2003 | 3 | 2:39 | Las Vegas, Nevada, United States | For the interim UFC Light Heavyweight Championship. |
| Win | 12–1 | Renato Sobral | KO (head kick) | UFC 40 | November 22, 2002 | 1 | 2:55 | Las Vegas, Nevada, United States | |
| Win | 11–1 | Vitor Belfort | Decision (unanimous) | UFC 37.5 | June 22, 2002 | 3 | 5:00 | Las Vegas, Nevada, United States | |
| Win | 10–1 | Amar Suloev | Decision (unanimous) | UFC 35 | January 11, 2002 | 3 | 5:00 | Uncasville, Connecticut, United States | |
| Win | 9–1 | Murilo Bustamante | Decision (unanimous) | UFC 33 | September 28, 2001 | 3 | 5:00 | Las Vegas, Nevada, United States | |
| Win | 8–1 | Guy Mezger | KO (punch) | Pride 14 - Clash of the Titans | May 27, 2001 | 2 | 0:21 | Kanagawa, Japan | |
| Win | 7–1 | Kevin Randleman | KO (punches) | UFC 31 | May 4, 2001 | 1 | 1:18 | Atlantic City, New Jersey, United States | |
| Win | 6–1 | Jeff Monson | Decision (unanimous) | UFC 29 | December 16, 2000 | 3 | 5:00 | Tokyo, Japan | |
| Win | 5–1 | Ron Kosakowski | KO (head kick) | IFC WC 9 | July 18, 2000 | 2 | 5:39 | Friant, California, United States | Won the IFC World Light Heavyweight Championship. |
| Win | 4–1 | Paul Jones | TKO (punches) | UFC 22 | September 24, 1999 | 1 | 3:53 | Lake Charles, Louisiana, United States | |
| Win | 3–1 | Kenneth Williams | Submission (rear-naked choke) | NG 11 | March 31, 1999 | 1 | 3:35 | Los Angeles, California, United States | |
| Loss | 2–1 | Jeremy Horn | Technical Submission (arm-triangle choke) | UFC 19 | March 5, 1999 | 1 | 12:00 | Bay St. Louis, Mississippi, United States | |
| Win | 2–0 | Jose Landi-Jons | Decision (unanimous) | IVC 6 | August 23, 1998 | 1 | 30:00 | São Paulo, Brazil | |
| Win | 1–0 | Noe Hernandez | Decision (unanimous) | UFC 17 | May 15, 1998 | 1 | 12:00 | Mobile, Alabama, United States | |