| Year | Title | Role | Notes |
| 1978 | Up in Smoke | Pedro de Pacas | |
| 1980 | Cheech and Chong's Next Movie | Cheech/Dwayne "Red" Mendoza | |
| 1981 | Nice Dreams | Cheech | |
| 1982 | Things Are Tough All Over | Cheech/Mr.Slyman/Narrator | |
| 1983 | Still Smokin' | Cheech | |
| Yellowbeard | El Segundo | |
| 1984 | Cannonball Run II | Tire Store Employee | |
| Cheech & Chong's The Corsican Brothers | Corsican Brother | |
| 1985 | Get Out of My Room | Cheech/Ian Rotten | |
| After Hours | Neil | |
| 1986 | Charlie Barnett's Terms of Enrollment | Elvis Friend & Fan | |
| Echo Park | Sid | |
| 1987 | Born in East L.A. | Rudy Robles | Also director and writer |
| Fatal Beauty | Bartender | |
| 1988 | Mickey's 60th Birthday | Disney Janitor | |
| Oliver & Company | Tito the Chihuahua (voice) | |
| 1989 | Ghostbusters II | Dock Supervisor | |
| Rude Awakening | Jesus Monteya | |
| Troop Beverly Hills | Himself | |
| 1990 | Far Out Man | Cheech | |
| The Shrimp on the Barbie | Carlos Munoz | |
| Mother Goose Rock 'n' Rhyme | Carnival Barker | |
| 1992 | Ferngully: The Last Rainforest | Stump (voice) | |
| 1994 | Charlie's Ghost Story | Coronado | |
| The Magic of the Golden Bear: Goldy III | Master Borgia | |
| A Million to Juan | Shell Shock | |
| The Lion King | Banzai (voice) | |
| 1995 | Desperado | Short Bartender | |
| 1996 | From Dusk till Dawn | Border Guard/Chet Pussy/Carlos | |
| The Great White Hype | Julio Escobar | |
| Tin Cup | Romeo Posar | |
| 1998 | Paulie | Ignacio | |
| 1999 | The Nuttiest Nutcracker | Mac (voice) | Direct-to-video |
| 2000 | See You in My Dreams | Estaban | |
| Luminarias | Jesus | |
| Picking Up the Pieces | Mayor Machado | |
| 2001 | Spy Kids | Felix Gumm The Fake Uncle | |
| 2002 | Spy Kids 2: The Island of Lost Dreams | Cameo |
| Pinocchio | The Fox (voice) | English dub |
| 2003 | Masked and Anonymous | Prospero | |
| Spy Kids 3-D: Game Over | Felix Gumm The Fake Uncle | Cameo |
| Once Upon a Time in Mexico | Belini | |
| Good Boy! | The Henchmen (voice) | |
| 2004 | The Lion King 1½ | Banzai (voice) | Direct-to-video |
| Christmas with the Kranks | Officer Salino | |
| 2005 | Sian Ka'an | Unknown role (voice) | |
| Fall Down a School | Erick Matthew, 202, 26, 57, 211 Bus Motorists (voices) | |
| Underclassman | Captain Victor Delgado | |
| 2006 | Cars | Ramone (voice) | |
