| Year | Title | Role | Notes |
| 1998 | Significant Others | Patti Pasternak | Episode: "My Left Kidney" |
| 1998 | Grace and Glorie | Charlene Stiles | TV film |
| 1999 | Spin City | Gayle | Episode: "Carter & Stuart & Bennett & Deirdre" |
| 1999 | Sex and the City | Madeline Dunn | Episode: "The Chicken Dance" |
| 2001 | Emeril | Benson | Main role |
| 2003 | Good Morning, Miami | Kiera | Episode: "The Slow and the Furious" |
| 2003–04, 2006 | Law & Order: Criminal Intent | Megan Colby / Doreen Whitlock / Lena Copeland | Episodes: "Zoonotic", "Magnificat", "Bedfellows" |
| 2004 | Wonderfalls | Sister Katrina | Episode: "Wound-up Penguin" |
| 2004 | Hope & Faith | Sally Jones | Episode: "Queer as Hope" |
| 2005 | Numbers | Vicky Sites | Episode: "Dirty Bomb" |
| 2005 | The Inside | Kelly Comack | Episode: "Pre-Filer" |
| 2006 | Arrested Development | Jan Eagleman | Episode: "Fakin' It" |
| 2007 | Lost | Emily Linus | Episode: "The Man Behind the Curtain" |
| 2007 | Desperate Housewives | Lucy | Episode: "You Can't Judge a Book by Its Cover" |
| 2008–2014 | True Blood | Arlene Fowler | Main role |
| 2009 | Private Practice | Yvonne Pierce | Episode: "Do the Right Thing" |
| 2010–2016 | The Good Wife | Elsbeth Tascioni | Recurring role (seasons 1, 3–7) |
| 2011 | True Blood: Jessica's Blog | Arlene Fowler | Episode: "The Ethics of Glamouring" |
| 2011 | Law & Order: Special Victims Unit | Bella Zane | Episode: "Educated Guess" |
| 2012 | Royal Pains | Jackie Van Ark | Episode: "Hurts Like a Mother" |
| 2012–2016 | Person of Interest | Grace Hendricks | Recurring role (seasons 1–3, 5) |
| 2014 | The Following | Judy | Episodes: "Resurrection", "For Joe", "Trust Me" |
| 2014 | Getting On | Denya Thorp | Episode: "The 7th Annual Christmas Card Competition" |
| 2014 | Recorded Lives | Risa | TV series |
| 2015 | Happyish | Debbie | Main role |
| 2016 | Crowded | Martina Moore | Main role |
| 2016 | Grace and Frankie | Krystle | Episode: "The Goodbyes" |
| 2017 | When We Rise | Sally Miller Gearhart | TV miniseries |
| 2017 | The Celebrity Perspective | Guest | TV series |
| 2017 | Dating Game Killer | Carol Jensen | TV film |
| 2017–2022 | The Good Fight | Elsbeth Tascioni | Recurring role and director (5 episodes) |
| 2017–2022 | Claws | Polly Marks | Main role |
| 2018 | Brockmire | Elle | Recurring role (season 2) |
| 2018 | RuPaul's Drag Race | Herself | Guest judge, episode: "The Bossy Rossy Show" |
| 2021 | Dr. Death | Robbie McClung | Episodes: "Feet of Clay", "Hardwood Floors" |
| 2024–present | Elsbeth | Elsbeth Tascioni | Main role; also executive producer |
