| No. | Result | Record | Opponent | Type | Round, time | Date | Location | Notes |
| 68 | Loss | 63–3–2 | Terence Crawford | UD | 12 | 13 Sep 2025 | Allegiant Stadium, Paradise, Nevada, U.S. | Lost WBA (Super), WBC, IBF, WBO, and The Ring super middleweight titles |
| 67 | Win | 63–2–2 | William Scull | UD | 12 | 3 May 2025 | ANB Arena, Riyadh, Saudi Arabia | Retained WBA (Super), WBC, WBO, and The Ring super middleweight titles;Won IBF super middleweight title |
| 66 | Win | 62–2–2 | Edgar Berlanga | UD | 12 | 14 Sep 2024 | T-Mobile Arena, Paradise, Nevada, U.S. | Retained WBA (Super), WBC, WBO, and The Ring super middleweight titles |
| 65 | Win | 61–2–2 | Jaime Munguía | UD | 12 | 4 May 2024 | T-Mobile Arena, Paradise, Nevada, U.S. | Retained WBA (Super), WBC, IBF, WBO, and The Ring super middleweight titles |
| 64 | Win | 60–2–2 | Jermell Charlo | UD | 12 | 30 Sep 2023 | T-Mobile Arena, Paradise, Nevada, U.S. | Retained WBA (Super), WBC, IBF, WBO, and The Ring super middleweight titles |
| 63 | Win | 59–2–2 | John Ryder | UD | 12 | 6 May 2023 | Estadio Akron, Zapopan, Mexico | Retained WBA (Super), WBC, IBF, WBO, and The Ring super middleweight titles |
| 62 | Win | 58–2–2 | Gennady Golovkin | UD | 12 | 17 Sep 2022 | T-Mobile Arena, Paradise, Nevada, U.S. | Retained WBA (Super), WBC, IBF, WBO, and The Ring super middleweight titles |
| 61 | Loss | 57–2–2 | Dmitry Bivol | UD | 12 | 7 May 2022 | T-Mobile Arena, Paradise, Nevada, U.S. | For WBA (Super) light heavyweight title |
| 60 | Win | 57–1–2 | Caleb Plant | TKO | 11 (12), 1:05 | 6 Nov 2021 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Retained WBA (Super), WBC, WBO, and The Ring super middleweight titles;Won IBF super middleweight title |
| 59 | Win | 56–1–2 | Billy Joe Saunders | RTD | 8 (12), 3:00 | 8 May 2021 | AT&T Stadium, Arlington, Texas, U.S. | Retained WBA (Super), WBC, and The Ring super middleweight titles;Won WBO super middleweight title |
| 58 | Win | 55–1–2 | Avni Yıldırım | RTD | 3 (12), 3:00 | 27 Feb 2021 | Hard Rock Stadium, Miami Gardens, Florida, U.S. | Retained WBA (Super), WBC, and The Ring super middleweight titles |
| 57 | Win | 54–1–2 | Callum Smith | UD | 12 | 19 Dec 2020 | Alamodome, San Antonio, Texas, U.S. | Won WBA (Super), The Ring, and vacant WBC super middleweight titles |
| 56 | Win | 53–1–2 | Sergey Kovalev | KO | 11 (12), 2:15 | 2 Nov 2019 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Won WBO light heavyweight title |
| 55 | Win | 52–1–2 | Daniel Jacobs | UD | 12 | 4 May 2019 | T-Mobile Arena, Paradise, Nevada, U.S. | Retained WBA (Super), WBC, and The Ring middleweight titles;Won IBF middleweight title |
| 54 | Win | 51–1–2 | Rocky Fielding | TKO | 3 (12), 2:38 | 15 Dec 2018 | Madison Square Garden, New York City, New York, U.S. | Won WBA (Regular) super middleweight title |
| 53 | Win | 50–1–2 | Gennady Golovkin | MD | 12 | 15 Sep 2018 | T-Mobile Arena, Paradise, Nevada, U.S. | Won WBA (Super), WBC, and vacant The Ring middleweight titles |
| 52 | Draw | 49–1–2 | Gennady Golovkin | SD | 12 | 16 Sep 2017 | T-Mobile Arena, Paradise, Nevada, U.S. | Retained The Ring middleweight title;For WBA (Super), WBC, and IBF middleweight titles |
| 51 | Win | 49–1–1 | Julio César Chávez Jr. | UD | 12 | 6 May 2017 | T-Mobile Arena, Paradise, Nevada, U.S. | |
| 50 | Win | 48–1–1 | Liam Smith | KO | 9 (12), 2:28 | 17 Sep 2016 | AT&T Stadium, Arlington, Texas, U.S. | Won WBO light middleweight title |
| 49 | Win | 47–1–1 | Amir Khan | KO | 6 (12), 2:37 | 7 May 2016 | T-Mobile Arena, Paradise, Nevada, U.S. | Retained WBC and The Ring middleweight titles |
| 48 | Win | 46–1–1 | Miguel Cotto | UD | 12 | 21 Nov 2015 | Mandalay Bay Events Center, Paradise, Nevada, U.S. | Won The Ring and vacant WBC middleweight titles |
| 47 | Win | 45–1–1 | James Kirkland | KO | 3 (12), 2:19 | 9 May 2015 | Minute Maid Park, Houston, Texas, U.S. | |
| 46 | Win | 44–1–1 | Erislandy Lara | SD | 12 | 12 Jul 2014 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | |
| 45 | Win | 43–1–1 | Alfredo Angulo | TKO | 10 (12), 0:44 | 8 Mar 2014 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | |
| 44 | Loss | 42–1–1 | Floyd Mayweather Jr. | MD | 12 | 14 Sep 2013 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Lost WBC and The Ring light middleweight titles;For WBA (Super) light middleweight title |
| 43 | Win | 42–0–1 | Austin Trout | UD | 12 | 20 Apr 2013 | Alamodome, San Antonio, Texas, U.S. | Retained WBC light middleweight title;Won WBA (Unified) and vacant The Ring light middleweight titles |
| 42 | Win | 41–0–1 | Josesito López | TKO | 5 (12), 2:55 | 15 Sep 2012 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Retained WBC light middleweight title |
| 41 | Win | 40–0–1 | Shane Mosley | UD | 12 | 5 May 2012 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Retained WBC light middleweight title |
| 40 | Win | 39–0–1 | Kermit Cintrón | TKO | 5 (12), 2:53 | 26 Nov 2011 | Plaza de Toros, Mexico City, Mexico | Retained WBC light middleweight title |
| 39 | Win | 38–0–1 | Alfonso Gómez | TKO | 6 (12), 2:36 | 17 Sep 2011 | Staples Center, Los Angeles, California, U.S. | Retained WBC light middleweight title |
| 38 | Win | 37–0–1 | Ryan Rhodes | TKO | 12 (12), 0:48 | 18 Jun 2011 | Arena VFG, Guadalajara, Mexico | Retained WBC light middleweight title |
| 37 | Win | 36–0–1 | Matthew Hatton | UD | 12 | 5 Mar 2011 | Honda Center, Anaheim, California, U.S. | Won vacant WBC light middleweight title |
| 36 | Win | 35–0–1 | Lovemore N'dou | UD | 12 | 4 Dec 2010 | Estadio Universitario Beto Ávila, Veracruz, Mexico | Retained WBC Silver light middleweight title |
| 35 | Win | 34–0–1 | Carlos Baldomir | KO | 6 (10), 2:58 | 18 Sep 2010 | Staples Center, Los Angeles, California, U.S. | Retained WBC Silver light middleweight title |
| 34 | Win | 33–0–1 | Luciano Leonel Cuello | TKO | 6 (12), 1:23 | 10 Jul 2010 | Arena VFG, Guadalajara, Mexico | Won vacant WBC Silver light middleweight title |
| 33 | Win | 32–0–1 | José Cotto | TKO | 9 (10), 2:51 | 1 May 2010 | MGM Grand Garden Arena, Paradise, Nevada, U.S. | |
| 32 | Win | 31–0–1 | Brian Camechis | KO | 3 (12), 0:23 | 6 Mar 2010 | Palenque de la Feria, Tuxtla Gutiérrez, Mexico | Retained NABF welterweight title |
| 31 | Win | 30–0–1 | Lanardo Tyner | UD | 12 | 5 Dec 2009 | Tepic, Mexico | Retained NABF welterweight title |
| 30 | Win | 29–0–1 | Carlos Herrera | TKO | 1 (10), 2:46 | 15 Sep 2009 | Auditorio Siglo XXI, Puebla, Mexico | Retained WBC Youth welterweight title |
| 29 | Win | 28–0–1 | Marat Khuzeev | KO | 2 (10), 2:33 | 8 Aug 2009 | Auditorio Benito Juárez, Zapopan, Mexico | Won vacant WBC Youth welterweight title |
| 28 | Win | 27–0–1 | Jefferson Gonçalo | KO | 9 (12), 1:54 | 6 Jun 2009 | Xcaret Park, Cancún, Mexico | Retained NABF welterweight title |
| 27 | Win | 26–0–1 | Michel Rosales | TKO | 10 (12), 2:53 | 11 Apr 2009 | Gimnasio Niños Héroes, Tepic, Mexico | Retained NABF welterweight title |
| 26 | Win | 25–0–1 | Euri González | TKO | 11 (12), 1:36 | 21 Feb 2009 | Auditorio Benito Juárez, Zapopan, Mexico | Retained NABF welterweight title;Won WBO Latino welterweight title |
| 25 | Win | 24–0–1 | Antonio Fitch | TKO | 1 (12), 1:52 | 17 Jan 2009 | Foro Scotiabank, Mexico City, Mexico | Won vacant NABF welterweight title |
| 24 | Win | 23–0–1 | Raúl Pinzón | TKO | 1 (12), 2:30 | 5 Dec 2008 | Miccosukee Resort & Gaming, Miami, Florida, U.S. | Retained WBA Fedecentro welterweight title |
| 23 | Win | 22–0–1 | Larry Mosley | UD | 10 | 24 Oct 2008 | Morongo Casino Resort & Spa, Cabazon, California, U.S. | |
| 22 | Win | 21–0–1 | Carlos Adán Jerez | UD | 10 | 2 Aug 2008 | Auditorio Benito Juárez, Zapopan, Mexico | Retained WBA Fedecentro welterweight title |
| 21 | Win | 20–0–1 | Miguel Vázquez | UD | 10 | 28 Jun 2008 | Palenque Calle 2, Zapopan, Mexico | |
| 20 | Win | 19–0–1 | Francisco Villanueva | SD | 10 | 6 Jun 2008 | Tepic, Mexico | |