| Marcos Jr. Cabinet |
| Incumbent | Office | Department(Constituting instrument) | Acronym | Took office |
| | Ralph RectoAd interim | Executive Secretary | Office of the Executive Secretary(Executive Order No. 292, s. 1987) | OES | November 17, 2025 |
| | Ma. Theresa Lazaro | Secretary of Foreign Affairs | Foreign Affairs(Commonwealth Act No. 732) | DFA | July 1, 2025 |
| | Frederick GoAd interim | Secretary of Finance | Finance(Executive Order No. 292, s. 1987) | DOF | November 17, 2025 |
| | Gilberto Teodoro | Secretary of National Defense | National Defense(Commonwealth Act No. 1) | DND | June 5, 2023 |
| | Fredderick VidaActing | Secretary of Justice | Justice(Executive Order No. 292, s. 1987) | DOJ | October 10, 2025 |
| | Juanito Victor Remulla Jr. | Secretary of the Interior and Local Government | Interior and Local Government(Republic Act No. 6975) | DILG | October 8, 2024 |
| | Francisco Tiu Laurel Jr. | Secretary of Agriculture | Agriculture(Presidential Decree No. 461, s. 1974) | DA | November 3, 2023 |
| | Maria Cristina Roque | Secretary of Trade and Industry | Trade and Industry(Executive Order No. 133, s. 1987) | DTI | August 2, 2024 |
| | Bienvenido Laguesma | Secretary of Labor and Employment | Labor and Employment(Executive Order No. 292, s. 1987) | DOLE | June 30, 2022 |
| | Teodoro Herbosa | Secretary of Health | Health(Executive Order No. 94, s. 1947) | DOH | June 5, 2023 |
| | Jose Ramon Aliling | Secretary of Human Settlements and Urban Development | Human Settlements and Urban Development(Republic Act No. 11201) | DHSUD | May 23, 2025 |
| | Giovanni Z. LopezActing | Secretary of Transportation | Transportation(Republic Act No. 10844) | DOTr | September 1, 2025 |
| | Sharon Garin | Secretary of Energy | Energy(Republic Act No. 7638) | DOE | May 23, 2025 |
| | Juan Eduardo Angara | Secretary of Education | Education(Republic Act No. 9155) | DepEd | July 19, 2024 |
| | Raphael LotillaAd interim | Secretary of Environment and Natural Resources | Environment and Natural Resources(Presidential Decree No. 461, s. 1974) | DENR | May 23, 2025 |
| | Rolando ToledoActing | Secretary of Budget and Management | Budget and Management(Presidential Decree No. 1405, s. 1978) | DBM | November 17, 2025 |
| | Renato Solidum Jr. | Secretary of Science and Technology | Science and Technology(Executive Order No. 128, s. 1987) | DOST | July 22, 2022 |
| | Conrado Estrella III | Secretary of Agrarian Reform | Agrarian Reform(Republic Act No. 6657) | DAR | June 30, 2022 |
| | Ma. Christina Frasco | Secretary of Tourism | Tourism(Executive Order No. 120, s. 1987) | DOT | June 30, 2022 |
| | Rexlon Gatchalian | Secretary of Social Welfare and Development | Social Welfare and Development(Presidential Decree No. 994, s. 1976) | DSWD | January 31, 2023 |
| | Vince DizonAd interim | Secretary of Public Works and Highways | Public Works and Highways(Executive Order No. 124-A, s. 1987) | DPWH | September 1, 2025 |
| | Henry Rhoel Aguda | Secretary of Information and Communications Technology | Information and Communications Technology(Republic Act No. 10844) | DICT | March 20, 2025 |
| | Hans Leo Cacdac | Secretary of Migrant Workers | Migrant Workers(Republic Act No. 11641) | DMW | August 20, 2024 |
| | Arsenio Balisacan | Secretary of Economy, Planning and Development | Economy, Planning and Development(Republic Act No. 12145) | DEPDev | June 30, 2022 |
| | Eduardo Año | National Security Adviser | National Security Council(Executive Order No. 330, s. 1950) | NSC | January 14, 2023 |
| | TBA | Special Assistant to the President for Investment and Economic Affairs | Office of the Special Assistant to the President for Investment and Economic Affairs(Executive Order No. 292, s. 2024) | OSAPIEA | |
| | Elaine Masukat | Secretary of the Presidential Management Staff | Presidential Management(Executive Order No. 250, s. 1970) | PMS | January 3, 2023 |
| | TBA | Chief Presidential Legal Counsel | Office of the Chief Presidential Legal Counsel(Executive Order No. 152, s. 2004) | OCPLC | No incumbent |
| | Andres Centino | Presidential Assistant for Maritime Concerns | Presidential Office for Maritime Concerns(Executive Order No. 57, s. 2024) | POMC | September 28, 2023 |
| | Jose Acuzar | Presidential Adviser for Pasig River Rehabilitation | Inter-Agency Council for Pasig River Urban Development(Executive Order No. 35, s. 2023) | IACPRUD | May 23, 2025 |
| | Carlito Galvez Jr. | Presidential Adviser on Peace, Reconciliation and Unity | Office of the Presidential Adviser on Peace, Reconciliation and Unity(Executive Order No. 125, s. 1993) | OPAPRU | June 26, 2023 |
| | Lorenzo Gadon | Presidential Adviser for Poverty Alleviation | Office of the Presidential Adviser for Poverty Alleviation(Administrative Order No. 6, s. 1998) | OPAPA | June 26, 2023 |
| | TBA | Presidential Assistant for the Visayas | Office of the Presidential Assistant for the Visayas(Memorandum Order No. 8, s. 2016) | OPAV | No incumbent |
| | Antonio Cerilles | Presidential Adviser for Mindanao Concerns | Office of the Presidential Adviser for Mindanao Concerns | OPMC | March 13, 2025 |
| | Antonio Lagdameo Jr. | Special Assistant to the President | Office of the Special Assistant to the President(Executive Order No. 1, s. 2016) | OSAP | June 30, 2022 |
| | Darlene Marie Berberabe | Solicitor General | Office of the Solicitor General of the Philippines(Act No. 136) | OSG | May 29, 2025 |
| | Dave GomezAd interim | Secretary of the Presidential Communications Office | Presidential Communications Office(Executive Order No. 4, s. 2010) | PCO | July 10, 2025 |