| Year | Title | Role | Notes |
| 1999 | Saving Graces | Mindy | TV series |
| 1999–2000 | Freaks and Geeks | Kim Kelly | 18 episodes |
| 2000 | Malcolm in the Middle | Meghan | Episode: "High School Play" |
| 2001 | Anatomy of a Hate Crime | Chasity Pasley | Television film |
| Spring Break Lawyer | Jenny |
| Dead Last | Tracy Sallback | Episode: "Death Is in the Air" |
| 2001–2003 | Dawson's Creek | Audrey Liddell | Main role (season 6); recurring (season 5) |
| 2002 | Undeclared | Kelly | 2 episodes |
| 2003 | Criminology 101 | Polly | Television film |
| 2004 | Foster Hall | Peg Hall |
| 2005 | Life As We Know It | Alex Morrill | 2 episodes |
| Testing Bob | Madison 'Maddie' West | Television film |
| Super Robot Monkey Team Hyperforce Go! | Korlianne (voice) | Episode: "Girl Trouble" |
| 2005–2006 | Love, Inc. | Denise Johnson | 22 episodes |
| 2005, 2018 | American Dad! | Dana / Blanch (voices) | 2 episodes |
| 2006–2007 | ER | Dr. Hope Bobeck | 19 episodes |
| 2007 | Entourage | Cheryl | Episode: "Dog Day Afternoon" |
| How I Met Your Mother | Rachel | Episode: "Third Wheel" |
| 2008–2009 | Terminator: The Sarah Connor Chronicles | Kacy Corbin | 5 episodes |
| 2009 | Kath & Kim | Whitney | Episode: "Competition" |
| 2009–2015 | Cougar Town | Laurie Keller | Main role |
| 2011 | Community | Greendale Team Member | Episode: "For a Few Paintballs More" |
| Fish Hooks | Clamanda (voice) | Episode: "We've Got Fish Spirits" |
| 2012 | Don't Trust the B---- in Apartment 23 | Herself | Episode: "A Reunion..." |
| RuPaul's Drag Race All Stars | Episode: "RuPaul's Gaff In" |
| 2013 | Arrested Development | Joan | Episode: "Borderline Personalities" |
| 2014 | Garfunkel and Oates | Karen | 2 episodes |
| 2014–2018 | Drunk History | Various | 3 episodes |
| 2015 | Bottom's Butte | Beverly Bottom (voice) | Episode: "Pilot" |
| 2016 | New Girl | Connie | Episode: "300 Feet" |
| Angie Tribeca | Courtney Woodpatch-Newton | Episode: "Miso Dead" |
| Bajillion Dollar Propertie$ | Cate Kates | Episode: "Spiritual Gurus" |
| 2016–2017 | Vice Principals | Gale Liptrapp | Main role |
| 2017 | The Odd Couple | Natasha | Episode: "Should She Stay or Should She Go?" |
| Chopped Junior | Herself (guest judge) | Episode: "Curry Hurry" |
| The Sackett Sisters | Mandy Sackett | Episode: "Pilot" |
| Beat Bobby Flay | Herself (guest judge) | Episode: "Tame the Flame" |
| 2018 | Camping | Allison | Episode: "Up All Night" |
| 2018–2019 | Unbreakable Kimmy Schmidt | Sheba Goodman | 2 episodes |
| Busy Tonight | Herself | Main role; also executive producer |
| 2019 | Astronomy Club: The Sketch Show | | Episode: "Full House But Black" |
| 2021 | Search Party | Donna | Episode: "Home Again, Home Again, Jiggity-Jig" |
| 2021–2024 | Girls5eva | Summer Dutkowsky | Main role |
| 2023 | With Love | Amanda | Episode: "Lily's Double Quinceañera" |
| Single Drunk Female | Darby | 3 episodes |
| 2024–present | Busy This Week | Herself | Main role |
