| Year | Award | Category | Work | Result | Ref. |
| 2017 | FilmQuest | Best Supporting Actress – Feature | Domain | Nominated | |
| 2020 | Nashville Film Festival | Audience Award | Circus Person | Won | |
| 2022 | Hollywood Critics Association Awards | Best Actress in a Streaming Series, Drama | Severance | Won | |
| Saturn Awards | Best Actress in a Streaming Series | Nominated | |
| Gotham Awards | Outstanding Performance in a New Series | Nominated | |
| 2023 | Screen Actors Guild Awards | Outstanding Performance by an Ensemble in a Drama Series | Nominated | |
| 2025 | Canadian Screen Awards | Best Performance in a Leading Role, Drama | Darkest Miriam | Nominated | |
| Astra Awards | Best Actress in a Drama Series | Severance | Nominated | |
| Critics' Choice Super Awards | Best Actress in a Science Fiction/Fantasy Series, Limited Series or Made-for-TV Movie | Won | |
| TCA Awards | Individual Achievement in Drama | Nominated | |
| Primetime Emmy Awards | Outstanding Lead Actress in a Drama Series | Won | |
| 2026 | Critics' Choice Television Awards | Best Actress in a Drama Series | Nominated | |
| Golden Globe Awards | Best Actress – Television Series Drama | Pending | |
| Satellite Awards | Best Actress in a Drama or Genre Series | Pending | |