| No. | Result | Record | Opponent | Type | Round, time | Date | Age | Location | Notes |
| 73 | Draw | 62–8–3 | Mario Barrios | MD | 12 | Jul 19, 2025 | 46 years, 214 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | For WBC welterweight title |
| 72 | Loss | 62–8–2 | Yordenis Ugás | UD | 12 | Aug 21, 2021 | 42 years, 247 days | T-Mobile Arena, Paradise, Nevada, U.S. | For WBA (Super) welterweight title |
| 71 | Win | 62–7–2 | Keith Thurman | SD | 12 | Jul 20, 2019 | 40 years, 215 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Won WBA (Super) welterweight title |
| 70 | Win | 61–7–2 | Adrien Broner | UD | 12 | Jan 19, 2019 | 40 years, 33 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Retained WBA (Regular) welterweight title |
| 69 | Win | 60–7–2 | Lucas Matthysse | TKO | 7 (12), 2:43 | Jul 15, 2018 | 39 years, 210 days | Axiata Arena, Kuala Lumpur, Malaysia | Won WBA (Regular) welterweight title |
| 68 | Loss | 59–7–2 | Jeff Horn | UD | 12 | Jul 2, 2017 | 38 years, 197 days | Suncorp Stadium, Brisbane, Australia | Lost WBO welterweight title |
| 67 | Win | 59–6–2 | Jessie Vargas | UD | 12 | Nov 5, 2016 | 37 years, 324 days | Thomas & Mack Center, Paradise, Nevada, U.S. | Won WBO welterweight title |
| 66 | Win | 58–6–2 | Timothy Bradley | UD | 12 | Apr 9, 2016 | 37 years, 114 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Won vacant WBO International welterweight title |
| 65 | Loss | 57–6–2 | Floyd Mayweather Jr. | UD | 12 | May 2, 2015 | 36 years, 136 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Lost WBO welterweight title;For WBA (Unified), WBC, and The Ring welterweight titles |
| 64 | Win | 57–5–2 | Chris Algieri | UD | 12 | Nov 23, 2014 | 35 years, 341 days | Cotai Arena, Macau, China SAR | Retained WBO welterweight title |
| 63 | Win | 56–5–2 | Timothy Bradley | UD | 12 | Apr 12, 2014 | 35 years, 116 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Won WBO welterweight title |
| 62 | Win | 55–5–2 | Brandon Ríos | UD | 12 | Nov 24, 2013 | 34 years, 342 days | Cotai Arena, Macau, China SAR | Won vacant WBO International welterweight title |
| 61 | Loss | 54–5–2 | Juan Manuel Márquez | KO | 6 (12), 2:59 | Dec 8, 2012 | 33 years, 357 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | |
| 60 | Loss | 54–4–2 | Timothy Bradley | SD | 12 | Jun 9, 2012 | 33 years, 175 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Lost WBO welterweight title |
| 59 | Win | 54–3–2 | Juan Manuel Márquez | MD | 12 | Nov 12, 2011 | 32 years, 330 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Retained WBO welterweight title |
| 58 | Win | 53–3–2 | Shane Mosley | UD | 12 | May 7, 2011 | 32 years, 141 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Retained WBO welterweight title |
| 57 | Win | 52–3–2 | Antonio Margarito | UD | 12 | Nov 13, 2010 | 31 years, 331 days | Cowboys Stadium, Arlington, Texas, U.S. | Won vacant WBC super welterweight title |
| 56 | Win | 51–3–2 | Joshua Clottey | UD | 12 | Mar 13, 2010 | 31 years, 86 days | Cowboys Stadium, Arlington, Texas, U.S. | Retained WBO welterweight title |
| 55 | Win | 50–3–2 | Miguel Cotto | TKO | 12 (12), 0:55 | Nov 14, 2009 | 30 years, 332 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Won WBO welterweight title |
| 54 | Win | 49–3–2 | Ricky Hatton | KO | 2 (12), 2:59 | May 2, 2009 | 30 years, 136 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Won IBO and The Ring light welterweight titles |
| 53 | Win | 48–3–2 | Oscar De La Hoya | RTD | 8 (12), 3:00 | Dec 6, 2008 | 29 years, 355 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | |
| 52 | Win | 47–3–2 | David Díaz | TKO | 9 (12), 2:24 | Jun 28, 2008 | 29 years, 194 days | Mandalay Bay Events Center, Paradise, Nevada, U.S. | Won WBC lightweight title |
| 51 | Win | 46–3–2 | Juan Manuel Márquez | SD | 12 | Mar 15, 2008 | 29 years, 89 days | Mandalay Bay Events Center, Paradise, Nevada, U.S. | Won WBC and vacant The Ring super featherweight titles |
| 50 | Win | 45–3–2 | Marco Antonio Barrera | UD | 12 | Oct 6, 2007 | 28 years, 293 days | Mandalay Bay Events Center, Paradise, Nevada, U.S. | Retained WBC International super featherweight title |
| 49 | Win | 44–3–2 | Jorge Solís | KO | 8 (12), 1:16 | Apr 14, 2007 | 28 years, 118 days | Alamodome, San Antonio, Texas, U.S. | Retained WBC International super featherweight title |
| 48 | Win | 43–3–2 | Érik Morales | KO | 3 (12), 2:57 | Nov 18, 2006 | 27 years, 336 days | Thomas & Mack Center, Paradise, Nevada, U.S. | Retained WBC International super featherweight title |
| 47 | Win | 42–3–2 | Óscar Larios | UD | 12 | Jul 2, 2006 | 27 years, 197 days | Araneta Coliseum, Quezon City, Philippines | Retained WBC International super featherweight title |
| 46 | Win | 41–3–2 | Érik Morales | TKO | 10 (12), 2:33 | Jan 21, 2006 | 27 years, 35 days | Thomas & Mack Center, Paradise, Nevada, U.S. | Retained WBC International super featherweight title |
| 45 | Win | 40–3–2 | Héctor Velázquez | TKO | 6 (12), 2:59 | Sep 10, 2005 | 26 years, 267 days | Staples Center, Los Angeles, California, U.S. | Won vacant WBC International super featherweight title |
| 44 | Loss | 39–3–2 | Érik Morales | UD | 12 | Mar 19, 2005 | 26 years, 92 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | For IBA and vacant WBC International super featherweight titles |
| 43 | Win | 39–2–2 | Narongrit Pirang | KO | 4 (12), 1:26 | Dec 11, 2004 | 25 years, 360 days | MC Home Depot Fort, Taguig, Philippines | Retained The Ring featherweight title |
| 42 | Draw | 38–2–2 | Juan Manuel Márquez | SD | 12 | May 8, 2004 | 25 years, 143 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Retained The Ring featherweight title;For WBA (Unified) and IBF featherweight titles |
| 41 | Win | 38–2–1 | Marco Antonio Barrera | TKO | 11 (12), 2:56 | Nov 15, 2003 | 24 years, 333 days | Alamodome, San Antonio, Texas, U.S. | Won The Ring featherweight title |
| 40 | Win | 37–2–1 | Emmanuel Lucero | KO | 3 (12), 0:48 | Jul 26, 2003 | 24 years, 221 days | Grand Olympic Auditorium, Los Angeles, California, U.S. | Retained IBF super bantamweight title |
| 39 | Win | 36–2–1 | Serikzhan Yeshmagambetov | TKO | 5 (10), 1:52 | Mar 15, 2003 | 24 years, 88 days | Rizal Park, Manila, Philippines | |
| 38 | Win | 35–2–1 | Fahprakorb Rakkiatgym | KO | 1 (12), 2:46 | Oct 26, 2002 | 23 years, 313 days | Rizal Memorial College Gym, Davao City, Philippines | Retained IBF super bantamweight title |
| 37 | Win | 34–2–1 | Jorge Eliécer Julio | TKO | 2 (12), 1:09 | Jun 8, 2002 | 23 years, 173 days | The Pyramid, Memphis, Tennessee, U.S. | Retained IBF super bantamweight title |
| 36 | Draw | 33–2–1 | Agapito Sánchez | TD | 6 (12), 1:12 | Nov 10, 2001 | 22 years, 328 days | Bill Graham Civic Auditorium, San Francisco, California, U.S. | Retained IBF super bantamweight title;For WBO super bantamweight title;Split TD: Pacquiao cut from an accidental head clash |
| 35 | Win | 33–2 | Lehlohonolo Ledwaba | TKO | 6 (12), 0:59 | Jun 23, 2001 | 22 years, 188 days | MGM Grand Garden Arena, Paradise, Nevada, U.S. | Won IBF super bantamweight title |
| 34 | Win | 32–2 | Foijan Prawet | KO | 6 (12), 2:40 | Apr 28, 2001 | 22 years, 132 days | Kidapawan, Cotabato, Philippines | Retained WBC International super bantamweight title |
| 33 | Win | 31–2 | Tetsutora Senrima | TKO | 5 (12), 1:06 | Feb 24, 2001 | 22 years, 69 days | Ynares Center, Antipolo, Philippines | Retained WBC International super bantamweight title |
| 32 | Win | 30–2 | Nedal Hussein | TKO | 10 (12), 1:48 | Oct 14, 2000 | 21 years, 302 days | Ynares Center, Antipolo, Philippines | Retained WBC International super bantamweight title |
| 31 | Win | 29–2 | Seung-Kon Chae | TKO | 1 (12), 1:42 | Jun 28, 2000 | 21 years, 194 days | Araneta Coliseum, Quezon City, Philippines | Retained WBC International super bantamweight title |
| 30 | Win | 28–2 | Arnel Barotillo | KO | 4 (12) | Mar 4, 2000 | 21 years, 78 days | Ninoy Aquino Stadium, Manila, Philippines | Retained WBC International super bantamweight title |
| 29 | Win | 27–2 | Reynante Jamili | KO | 2 (12) | Dec 18, 1999 | 21 years, 1 day | Elorde Sports Complex, Parañaque, Philippines | Won vacant WBC International super bantamweight title |
| 28 | Loss | 26–2 | Medgoen Singsurat | TKO | 3 (12), 1:32 | Sep 17, 1999 | 20 years, 274 days | Pakpanag Metropolitan Stadium, Nakhon Si Thammarat, Thailand | WBC flyweight title at stake only for Singsurat as Pacquiao missed weight |
| 27 | Win | 26–1 | Gabriel Mira | TKO | 4 (12), 2:45 | Apr 24, 1999 | 20 years, 128 days | Araneta Coliseum, Quezon City, Philippines | Retained WBC flyweight title |
| 26 | Win | 25–1 | Todd Makelim | TKO | 3 (10), 2:52 | Feb 20, 1999 | 20 years, 65 days | Kidapawan, Philippines | |
| 25 | Win | 24–1 | Chatchai Sasakul | KO | 8 (12), 2:54 | Dec 4, 1998 | 19 years, 352 days | Tonsuk College Ground, Phutthamonthon, Thailand | Won WBC flyweight title |