| Year | Nominated work | Category | Result |
| 1989 | — | Producer of the Year (Non-Classical) | Nominated |
| "Don't Be Cruel" | Best R&B Song | Nominated |
| 1990 | "Every Little Step" | Nominated |
| "Superwoman" | Nominated |
| "It's No Crime" | Best R&B Instrumental Performance | Nominated |
| — | Producer of the Year (Non-Classical) | Nominated |
| 1991 | "Whip Appeal" | Best R&B Vocal Performance, Male | Nominated |
| "My, My, My" | Best R&B Song | Nominated |
| 1993 | "End of the Road" | Won |
| — | Producer of the Year (Non-Classical) | Won |
| 1994 | The Bodyguard: Original Soundtrack Album (as a Producer) | Album of the Year | Won |
| "For the Cool in You" | Best R&B Vocal Performance, Male | Nominated |
| "Can We Talk" | Best R&B Song | Nominated |
| 1995 | "When Can I See You" | Best Male R&B Vocal Performance | Won |
| Best R&B Song | Nominated |
| "You Mean the World to Me" | Nominated |
| "I'll Make Love to You" | Won |
| Record of the Year | Nominated |
| 1996 | — | Producer of the Year | Won |
| "Someone to Love" (with Jon B.) | Best Pop Collaboration with Vocals | Nominated |
| "Someone to Love" | Best Song Written Specifically for a Motion Picture or for Television | Nominated |
| "Red Light Special" | Best R&B Song | Nominated |
| "You Can't Run" | Nominated |
| 1997 | "Sittin' up in My Room" | Nominated |
| "You're Makin' Me High" | Nominated |
| "Exhale (Shoop Shoop)" | Won |
| Song of the Year | Nominated |
| Best Song Written Specifically for a Motion Picture or for Television | Nominated |
| "It Hurts Like Hell" | Nominated |
| "Count On Me" | Nominated |
| "Change The World" (as a Producer) | Record of the Year | Won |
| "Slow Jams" | Best R&B Performance by a Duo or Group with Vocal | Nominated |
| — | Producer of the Year | Won |
| Secrets | Best Pop Album | Nominated |
| Waiting to Exhale: Original Soundtrack Album | Album of the Year | Nominated |
| 1998 | The Day | Nominated |
| Best R&B Album | Nominated |
| "Every Time I Close My Eyes" | Best Male Pop Vocal Performance | Nominated |
| — | Producer of the Year, Non-Classical | Won |
| "A Song for Mama" | Best Song Written Specifically for a Motion Picture or for Television | Nominated |
| "I Care 'Bout You" | Best Short Form Music Video | Nominated |
| "How Come, How Long" (feat. Stevie Wonder) | Nominated |
| Best Pop Collaboration with Vocals | Nominated |
| 1999 | "How Come, How Long" (Live) (feat. Stevie Wonder) | Nominated |
| 2000 | "When You Believe" | Best Song Written for a Motion Picture, Television or Other Visual Media | Nominated |
| FanMail | Album of the Year | Nominated |
| 2009 | Tha Carter III (as a Featured artist) | Nominated |
| 2013 | "Pray For Me" | Best R&B Song | Nominated |
| 2015 | Love, Marriage & Divorce (with Toni Braxton) | Best R&B Album | Won |