| # | Name | Replacing | Confirmation Vote Date | Term | Appointer | Prior Position |
| 1 | | John Rutledge | New seat | September 26, 1789 (Acclamation) | February 15, 1790 – March 4, 1791 (Resigned) | George Washington | Governor of South Carolina (1779–1782) |
| 2 | | William Cushing | New seat | September 26, 1789 (Acclamation) | February 2, 1790 – September 13, 1810 (Died) | Chief Justice of the Massachusetts Superior Court (1777–1789) |
| 3 | | James Wilson | New seat | September 26, 1789 (Acclamation) | October 5, 1789 – August 21, 1798 (Died) | Delegate to the Constitutional Convention (1787) |
| 4 | | John Blair | New seat | September 26, 1789 (Acclamation) | February 2, 1790 – October 25, 1795 (Resigned) | Member of the Virginia House of Burgesses (1766–1770) |
| 5 | | James Iredell | New seat | February 10, 1790 (Acclamation) | May 12, 1790 – October 20, 1799 (Died) | Attorney General of North Carolina (1779–1782) |
| 6 | | Thomas Johnson | J. Rutledge | November 7, 1791 (Acclamation) | September 19, 1791 – January 16, 1793 (Resigned) | Governor of Maryland (1777–1779) |
| 7 | | William Paterson | T. Johnson | March 4, 1793 (Acclamation) | March 11, 1793 – September 8, 1806 (Died) | Governor of New Jersey (1790–1793) |
| 8 | | Samuel Chase | Blair | January 27, 1796 (Acclamation) | February 4, 1796 – June 19, 1811 (Died) | Chief Justice of the Maryland General Court (1791–1796) |
| 9 | | Bushrod Washington | Wilson | December 20, 1798 (Acclamation) | November 9, 1798 – November 26, 1829 (Died) | John Adams | Delegate to the Virginia Ratifying Convention (1788) |
| 10 | | Alfred Moore | Iredell | December 9, 1799 (Acclamation) | April 21, 1800 – January 26, 1804 (Resigned) | Attorney General of North Carolina (1782–1791) |
| 11 | | William Johnson | Moore | March 24, 1804 (Acclamation) | May 7, 1804 – August 4, 1834 (Died) | Thomas Jefferson | Speaker of the South Carolina House of Representatives (1798–1800) |
| 12 | | Henry Brockholst Livingston | Paterson | December 17, 1806 (Acclamation) | January 20, 1807 – March 18, 1823 (Died) | Justice of the New York Supreme Court (1802–1807) |
| 13 | | Thomas Todd | New seat | March 2, 1807 (Acclamation) | March 4, 1807 – February 7, 1826 (Died) | Chief Justice of the Kentucky Court of Appeals (1806–1807) |
| 14 | | Gabriel Duvall | Chase | November 18, 1811 (Acclamation) | November 23, 1811 – January 12, 1835 (Resigned) | James Madison | U . Representative from Maryland's 2nd district (1794–1796) |
| 15 | | Joseph Story | Cushing | November 18, 1811 (Acclamation) | February 3, 1812 – September 10, 1845 (Died) | U . Representative from Massachusetts's 2nd district (1808–1809) |
| 16 | | Smith Thompson | Livingston | December 9, 1823 (Acclamation) | September 1, 1823 – December 18, 1843 (Died) | James Monroe | United States Secretary of the Navy (1819–1823) |
| 17 | | Robert Trimble | Todd | May 9, 1826 (25–5) | June 16, 1826 – August 25, 1828 (Died) | John Quincy Adams | Judge of the United States District Court for the District of Kentucky (1817–1826) |
| 18 | | John McLean | Trimble | March 7, 1829 (Acclamation) | March 12, 1829 – April 4, 1861 (Died) | Andrew Jackson | United States Postmaster General (1823–1829) |
| 19 | | Henry Baldwin | Washington | January 6, 1830 (41–2) | January 18, 1830 – April 21, 1844 (Died) | U . Representative from Pennsylvania's 14th district (1817–1822) |
| 20 | | James M. Wayne | W. Johnson | January 9, 1835 (Acclamation) | January 14, 1835 – July 5, 1867 (Died) | U . Representative from Georgia's at-large district (1829–1835) |
| 21 | | Philip P. Barbour | Duvall | March 15, 1836 (30–11) | May 12, 1836 – February 25, 1841 (Died) | Judge of the United States District Court for the Eastern District of Virginia (1830–1836) |
| 22 | | John Catron | New seat | March 8, 1837 (28–15) | May 1, 1837 – May 30, 1865 (Died) | Judge of the Tennessee Supreme Court of Errors and Appeals (1824–1834) |
| 23 | | John McKinley | New seat | September 25, 1837 (Acclamation) | January 9, 1838 – July 19, 1852 (Died) | Martin Van Buren | United States Senator from Alabama (1826–1831, 1837) |
| 24 | | Peter V. Daniel | Barbour | March 2, 1841 (25–5) | January 10, 1842 – May 31, 1860 (Died) | Judge of the United States District Court for the Eastern District of Virginia (1836–1841) |
| 25 | | Samuel Nelson | Thompson | February 14, 1845 (Acclamation) | February 27, 1845 – November 28, 1872 (Retired) | John Tyler | Chief Justice of the New York Supreme Court (1831–1845) |
| 26 | | Levi Woodbury | Story | January 31, 1846 (Acclamation) | September 23, 1845 – September 4, 1851 (Died) | James K. Polk | United States Secretary of the Treasury (1834–1841) |
| 27 | | Robert Cooper Grier | Baldwin | August 4, 1846 (Acclamation) | August 10, 1846 – January 31, 1870 (Retired) | Judge for the Pennsylvania District Court for Allegheny County (1833–1846) |
| 28 | | Benjamin Robbins Curtis | Woodbury | December 20, 1851 (Acclamation) | October 10, 1851 – September 30, 1857 (Resigned) | Millard Fillmore | Massachusetts State Representative |
| 29 | | John Archibald Campbell | McKinley | March 22, 1853 (Acclamation) | April 11, 1853 – April 30, 1861 (Resigned) | Franklin Pierce | Alabama State Representative |
| 30 | | Nathan Clifford | Curtis | January 12, 1858 (26–23) | January 21, 1858 – July 25, 1881 (Died) | James Buchanan | United States Attorney General (1846–1848) |
| 31 | | Noah Haynes Swayne | McLean | January 24, 1862 (38–1) | January 27, 1862 – January 24, 1881 (Retired) | Abraham Lincoln | U . attorney for the District of Ohio (1830–1834) |
| 32 | | Samuel Freeman Miller | Daniel | July 16, 1862 (Acclamation) | July 21, 1862 – October 13, 1890 (Died) | Lawyer, Private practice |
| 33 | | David Davis | Campbell | December 8, 1862 (Acclamation) | December 10, 1862 – March 3, 1877 (Resigned) | Judge of the Illinois 3rd Circuit Court (1848–1862) |
| 34 | | Stephen Johnson Field | New seat | March 10, 1863 (Acclamation) | May 20, 1863 – December 1, 1897 (Retired) Chief Justice of the California Supreme Court (1859–1863) |
| 35 | | William Strong | Grier | February 18, 1870 (Acclamation) | March 14, 1870 – December 14, 1880 (Retired) | Ulysses S. Grant | U . Representative from Pennsylvania's 9th district (1847–1851) |
| 36 | | Joseph P. Bradley | New seat | March 21, 1870 (46–9) | March 23, 1870 – January 22, 1892 (Died) | Lawyer, Private practice |
| 37 | | Ward Hunt | Nelson | December 11, 1872 (Acclamation) | January 9, 1873 – January 27, 1882 (Retired) | Chief Judge of the New York Court of Appeals (1868–1872) |
| 38 | | John Marshall Harlan | Davis | December 10, 1877 (Acclamation) | November 29, 1877 – October 14, 1911 (Died) | Rutherford B. Hayes | Attorney General of Kentucky (1863–1867) |
| 39 | | William Burnham Woods | Strong | December 21, 1880 (39–8) | January 5, 1881 – May 14, 1887 (Died) | Judge of the United States Court of Appeals for the Fifth Circuit (1869–1880) |
| 40 | | Stanley Matthews | Swayne | May 12, 1881 (24–23) | May 17, 1881 – March 22, 1889 (Died) | James A. Garfield | United States Senator from Ohio (1877–1879) |
| 41 | | Horace Gray | Clifford | December 20, 1881 (51–5) | January 9, 1882 – September 15, 1902 (Died) | Chester A. Arthur | Chief Justice of the Massachusetts Supreme Judicial Court (1873–1881) |
| 42 | | Samuel Blatchford | Hunt | March 22, 1882 (Acclamation) | April 3, 1882 – July 7, 1893 (Died) | Judge of the United States Court of Appeals for the Second Circuit (1878–1882) |
| 43 | | Lucius Quintus Cincinnatus Lamar II | Woods | January 16, 1888 (32–28) | January 18, 1888 – January 23, 1893 (Died) | Grover Cleveland | United States Secretary of the Interior (1885–1888) |
| 44 | | David Josiah Brewer | Matthews | December 18, 1889 (53–11) | January 6, 1890 – March 28, 1910 (Died) | Benjamin Harrison | Judge of the United States Court of Appeals for the Eighth Circuit (1884–1889) |
| 45 | | Henry Billings Brown | Miller | December 29, 1890 (Acclamation) | January 5, 1891 – May 28, 1906 (Retired) | Judge of the United States District Court for the Eastern District of Michigan (1875–1890) |
| 46 | | George Shiras Jr. | Bradley | July 26, 1892 (Acclamation) | October 10, 1892 – February 23, 1903 (Retired) | Lawyer, Private practice |
| 47 | | Howell Edmunds Jackson | L. Lamar | February 18, 1893 (Acclamation) | March 4, 1893 – August 8, 1895 (Died) | Judge of the United States Court of Appeals for the Sixth Circuit (1891–1893) |
| 48 | | Edward Douglass White | Blatchford | February 19, 1894 (Acclamation) | March 12, 1894 – December 18, 1910 (Continued as chief justice) | Grover Cleveland | United States Senator from Louisiana (1891–1894) |
| 49 | | Rufus W. Peckham | H. Jackson | December 9, 1895 (Acclamation) | January 6, 1896 – October 24, 1909 (Died) | Associate Judge of the New York Court of Appeals |