| No. | Result | Record | Opponent | Type | Round, time | Date | Location | Notes |
| 33 | Win | 29–4 | Jake Paul | KO | 6 (8), 1:31 | 19 Dec 2025 | Kaseya Center, Miami, US | |
| 32 | Loss | 28–4 | Daniel Dubois | KO | 5 (12), 0:59 | 21 Sep 2024 | Wembley Stadium, London, England | For IBF heavyweight title |
| 31 | Win | 28–3 | Francis Ngannou | KO | 2 (10), 2:38 | 8 Mar 2024 | Kingdom Arena, Riyadh, Saudi Arabia | |
| 30 | Win | 27–3 | Otto Wallin | RTD | 5 (12), 3:00 | 23 Dec 2023 | Kingdom Arena, Riyadh, Saudi Arabia | |
| 29 | Win | 26–3 | Robert Helenius | KO | 7 (12), 1:27 | 12 Aug 2023 | The O2 Arena, London, England | |
| 28 | Win | 25–3 | Jermaine Franklin | UD | 12 | 1 Apr 2023 | The O2 Arena, London, England | |
| 27 | Loss | 24–3 | Oleksandr Usyk | SD | 12 | 20 Aug 2022 | King Abdullah Sports City, Jeddah, Saudi Arabia | For WBA (Super), IBF, WBO, IBO, and vacant The Ring heavyweight titles |
| 26 | Loss | 24–2 | Oleksandr Usyk | UD | 12 | 25 Sep 2021 | Tottenham Hotspur Stadium, London, England | Lost WBA (Super), IBF, WBO, and IBO heavyweight titles |
| 25 | Win | 24–1 | Kubrat Pulev | KO | 9 (12), 2:58 | 12 Dec 2020 | Wembley Arena, London, England | Retained WBA (Super), IBF, WBO, and IBO heavyweight titles |
| 24 | Win | 23–1 | Andy Ruiz Jr. | UD | 12 | 7 Dec 2019 | Diriyah Arena, Diriyah, Saudi Arabia | Won WBA (Super), IBF, WBO, and IBO heavyweight titles |
| 23 | Loss | 22–1 | Andy Ruiz Jr. | TKO | 7 (12), 1:33 | 1 Jun 2019 | Madison Square Garden, New York, US | Lost WBA (Super), IBF, WBO, and IBO heavyweight titles |
| 22 | Win | 22–0 | Alexander Povetkin | TKO | 7 (12), 1:59 | 22 Sep 2018 | Wembley Stadium, London, England | Retained WBA (Super), IBF, WBO, and IBO heavyweight titles |
| 21 | Win | 21–0 | Joseph Parker | UD | 12 | 31 Mar 2018 | Principality Stadium, Cardiff, Wales | Retained WBA (Super), IBF, and IBO heavyweight titles;Won WBO heavyweight title |
| 20 | Win | 20–0 | Carlos Takam | TKO | 10 (12), 1:34 | 28 Oct 2017 | Principality Stadium, Cardiff, Wales | Retained WBA (Super), IBF, and IBO heavyweight titles |
| 19 | Win | 19–0 | Wladimir Klitschko | TKO | 11 (12), 2:25 | 29 Apr 2017 | Wembley Stadium, London, England | Retained IBF heavyweight title;Won vacant WBA (Super) and IBO heavyweight titles |
| 18 | Win | 18–0 | Éric Molina | TKO | 3 (12), 2:02 | 10 Dec 2016 | Manchester Arena, Manchester, England | Retained IBF heavyweight title |
| 17 | Win | 17–0 | Dominic Breazeale | TKO | 7 (12), 1:01 | 25 Jun 2016 | The O2 Arena, London, England | Retained IBF heavyweight title |
| 16 | Win | 16–0 | Charles Martin | KO | 2 (12), 1:32 | 9 Apr 2016 | The O2 Arena, London, England | Won IBF heavyweight title |
| 15 | Win | 15–0 | Dillian Whyte | TKO | 7 (12), 1:27 | 12 Dec 2015 | The O2 Arena, London, England | Retained WBC International and Commonwealth heavyweight titles;Won vacant British heavyweight title |
| 14 | Win | 14–0 | Gary Cornish | TKO | 1 (12), 1:37 | 12 Sep 2015 | The O2 Arena, London, England | Retained WBC International heavyweight title;Won vacant Commonwealth heavyweight title |
| 13 | Win | 13–0 | Kevin Johnson | TKO | 2 (10), 1:22 | 30 May 2015 | The O2 Arena, London, England | Retained WBC International heavyweight title |
| 12 | Win | 12–0 | Raphael Zumbano Love | TKO | 2 (8), 1:21 | 9 May 2015 | Barclaycard Arena, Birmingham, England | |
| 11 | Win | 11–0 | Jason Gavern | KO | 3 (8), 1:21 | 4 Apr 2015 | Metro Radio Arena, Newcastle, England | |
| 10 | Win | 10–0 | Michael Sprott | TKO | 1 (10), 1:26 | 22 Nov 2014 | Echo Arena, Liverpool, England | |
| 9 | Win | 9–0 | Denis Bakhtov | TKO | 2 (10), 1:00 | 11 Oct 2014 | The O2 Arena, London, England | Won vacant WBC International heavyweight title |
| 8 | Win | 8–0 | Konstantin Airich | TKO | 3 (8), 1:16 | 13 Sep 2014 | Phones 4u Arena, Manchester, England | |
| 7 | Win | 7–0 | Matt Skelton | TKO | 2 (6), 2:33 | 12 Jul 2014 | Echo Arena, Liverpool, England | |
| 6 | Win | 6–0 | Matt Legg | KO | 1 (6), 1:23 | 31 May 2014 | Wembley Stadium, London, England | |
| 5 | Win | 5–0 | Hector Alfredo Avila | KO | 1 (6), 2:14 | 1 Mar 2014 | Exhibition and Conference Centre, Glasgow, Scotland | |
| 4 | Win | 4–0 | Dorian Darch | TKO | 2 (6), 0:51 | 1 Feb 2014 | Motorpoint Arena, Cardiff, Wales | |
| 3 | Win | 3–0 | Hrvoje Kisiček | TKO | 2 (6), 1:38 | 14 Nov 2013 | York Hall, London, England | |
| 2 | Win | 2–0 | Paul Butlin | TKO | 2 (6), 0:50 | 26 Oct 2013 | Motorpoint Arena, Sheffield, England | |
| 1 | Win | 1–0 | Emanuele Leo | TKO | 1 (6), 2:47 | 5 Oct 2013 | The O2 Arena, London, England | |