| Organizations | Year | Category | Work | Result | Ref. |
| Black Reel Awards | 2002 | Best Supporting Actor | Two Can Play That Game | Nominated | |
| 2006 | Hustle & Flow | Nominated | |
| Critics' Choice Television Awards | 2015 | Best Actor in a Comedy Series | Black-ish (season 1) | Nominated | |
| 2016 | Black-ish (season 2) | Nominated | |
| 2017 | Black-ish (season 3) | Nominated | |
| 2018 | Black-ish (season 4) | Nominated | |
| Golden Globe Awards | 2016 | Best Actor in a Comedy Series | Black-ish (season 2) | Nominated | |
| 2017 | Black-ish (season 3) | Nominated | |
| NAACP Image Awards | 2002 | Outstanding Supporting Actor in a Motion Picture | Two Can Play That Game | Nominated | |
| 2003 | Barbershop | Nominated | |
| 2006 | Outstanding Actor in a Drama Series | K-Ville | Nominated | |
| 2009 | Law & Order | Nominated | |
| 2010 | Nominated | |
| 2011 | Nominated | |
| 2013 | Outstanding Actor in a Comedy Series | Guys with Kids | Nominated | |
| 2015 | Black-ish | Won | |
| 2016 | Won | |
| 2017 | Won | |
| Outstanding Host - Variety (Series or Special) | BET Awards 2016 (as host) | Nominated |
| 2018 | Outstanding Actor in a Comedy Series | Black-ish | Won | |
| 2019 | Won | |
| 2020 | Won | |
| 2021 | Won | |
| 2022 | Won | |
| Primetime Emmy Awards | 2015 | Outstanding Lead Actor in a Comedy Series | Black-ish (episode: "Sex, Lies, and Vasectomies") | Nominated | |
| 2016 | Outstanding Comedy Series (as a producer) | Black-ish (season 2) | Nominated | |
| Outstanding Lead Actor in a Comedy Series | Black-ish (episode: "Hope") | Nominated |
| 2017 | Outstanding Comedy Series (as a producer) | Black-ish (season 3) | Nominated | |
| Outstanding Lead Actor in a Comedy Series | Black-ish (episode: "Lemons") | Nominated |
| 2018 | Outstanding Comedy Series (as producer) | Black-ish (season 4) | Nominated | |
| Outstanding Lead Actor in a Comedy Series | Black-ish (episode: "Advance to Go (Collect $200)") | Nominated |
| 2019 | Outstanding Lead Actor in a Comedy Series | Black-ish (episode: "Purple Rain") | Nominated | |
| 2020 | Outstanding Lead Actor in a Comedy Series | Black-ish (episode: "Love, Boat") | Nominated | |
| 2021 | Outstanding Comedy Series (as a producer) | Black-ish (season 7) | Nominated | |
| Outstanding Lead Actor in a Comedy Series | Black-ish (episode: "What About Gary?") | Nominated |
| Screen Actors Guild Awards | 2005 | Outstanding Cast in a Motion Picture | Hustle & Flow | Nominated | |
| 2006 | Outstanding Cast in a Motion Picture | The Departed | Nominated | |
| 2016 | Outstanding Actor in a Comedy Series | Black-ish (season 2) | Nominated | |
| Outstanding Ensemble in a Comedy Series | Nominated |
| 2017 | Outstanding Actor in a Comedy Series | Black-ish (season 3) | Nominated | |
| Outstanding Ensemble in a Comedy Series | Nominated |
| Teen Choice Awards | 2004 | Choice TV Actor – Comedy | All About the Andersons | Nominated | |
| 2015 | Black-ish | Nominated | |
| 2017 | Nominated | |
| 2019 | Nominated | |