| Year | Association | Category | Work | Result | Ref. |
| 2014 | Juno Awards | Recording Package of the Year | White Paint | Nominated | |
| 2016 | Canadian Screen Awards | Best Performance in a Program or Series Produced for Digital Media | The Plateaus | Nominated | |
| Best Actress in a Comedy Series | Schitt's Creek | Nominated | |
| 2018 | Canadian Screen Awards | Nominated | |
| 2019 | Canadian Screen Awards | Nominated | |
| Critics' Choice Television Awards | Best Supporting Actress in a Comedy Series | Nominated | |
| Gracie Awards | Best Actress in a Breakthrough Role | Won | |
| Screen Actors Guild Awards | Outstanding Performance by an Ensemble in a Comedy Series | Nominated | |
| 2020 | Canadian Screen Awards | Best Actress in a Comedy Series | Nominated | |
| Dorian Awards | TV Musical Performance of the Year ("A Little Bit Alexis") | Nominated | |
| Best TV Performance – Supporting Actress | Won | |
| Primetime Emmy Awards | Outstanding Supporting Actress in a Comedy Series | Won | |
| 2021 | Canadian Screen Awards | Best Actress in a Comedy Series | Nominated | |
| Critics' Choice Television Awards | Best Supporting Actress in a Comedy Series | Nominated | |
| Golden Globe Awards | Best Supporting Actress – Series, Miniseries or Television Film | Nominated | |
| MTV Movie & TV Awards | Best Comedic Performance | Nominated | |
| Screen Actors Guild Awards | Outstanding Performance by a Female Actor in a Comedy Series | Nominated | |
| Outstanding Performance by an Ensemble in a Comedy Series | Won | |
| 2024 | Critics' Choice Super Awards | Best Actress in a Science Fiction/Fantasy Series | Black Mirror: "Joan Is Awful" | Won | |