| Year | Title | Role | Notes |
| 2009–10 | Crafty | Eli / Craft Service | Series regular (8 episodes) |
| 2010 | Big on the Web | Himself (host) | Unknown episode(s) |
| 2010 | The Surf Report | Himself (host) | Unknown episode(s) |
| 2012 | Punk'd | Field Agent | Recurring role (12 episodes)Segment producer (5 episodes) |
| 2012 | The Office | Ship Sales Transport Captain | Episode: "The Boat" |
| 2013 | Arrested Development | Employer | Episode: "The B. Team" |
| 2013 | Family Tree | Confederate Soldier | Episode: "Civil War" |
| 2013 | Children's Hospital | Jasper 'Pants' | Episode: "Imaginary Friends" |
| 2013 | Adam Devine's House Party | Himself | Episode: "Ex-Girlfriend" |
| 2013 | Who Gets the Last Laugh? | — | Field producerEpisode: "Kunal Nayyar / Bill Bellamy / Jeff Dye" |
| 2014 | Deadbeat | Sports Commentator | Episode: "The Hot God Contest" |
| 2014 | Mixology | Bruce | Series regular (13 episodes) |
| 2014 | The League | Shapps | Episode: "EBDBBnB" |
| 2014 | How I Met Your Dad | Danny | Unaired CBS/FOX pilot |
| 2014 | Last Call with Carson Daly | Himself (guest) | Episode: "J.B. / Andrew Santino / Warm Soda" |
| 2015 | Sin City Saints | Jake Tulius | Series regular (8 episodes) |
| 2015 | The Sixth Lead | Tow Truck Operator | Episode: "Trouble at the Security Gate" |
| 2015 | Conan | Himself (comic guest) | Episode: "Edward Norton / Melissa Rauch / Andrew Santino" |
| 2015 | Roast of Justin Bieber Pre-Show | Himself (host) | TV special |
| 2015 | The Meltdown with Jonah and Kumail | Himself (guest) | Episode: "The One with All the Spitting" |
| 2015 | The Half Hour | Himself (comedian) | Episode: "Must CC: The Half Hour" |
| 2016 | American Dad! | Jaramillo Henchman (voice role) | Episode: "Fight and Flight" |
| 2016–17 | Here's the Rub | Nikola Popov | Series regular, executive producer (12 episodes) |
| 2016–22 | This Is Us | Casey | 3 episodes |
| 2017 | The Late Late Show with James Corden | Himself (guest) | Episode: "Jim Carrey / Al Madrigal / Andrew Santino / Erik Griffin" |
| 2017–18 | I'm Dying Up Here | Billy Hobbs | Series regular (20 episodes) |
| 2018 | Alone Together | Kyle | Episode: "Nurse Esther" |
| 2019 | Fam | Spence | Episode: "Party Girl" |
| 2019–20 | Lights Out with David Spade | Himself (panelist) | 3 episodes |
| 2020 | Curb Your Enthusiasm | Plumber | Episode: "Insufficient Praise" |
| 2020–23 | Dave | Mike | Series regular (30 episodes) |
| 2021–23 | Ten Year Old Tom | Various voices | 5 episodes |
| 2021 | Fairfax | Biff (voice) | Episode: "Dale Hates His Dad" |
| 2023–present | Royal Crackers | Theodore "Theo" Hornsby Jr. (voice) | Main role |
| 2023 | Beef | Michael | Recurring role |
| 2024 | Dinner Time Live with David Chang | Himself (guest) | Episode: "Choose Your Own Adventure Volume 2" |
| 2025 | Last Meals | Himself (guest) | Episode: "Andrew Santino Eats His Last Meal" |