| No. | Result | Record | Opponent | Type | Round, time | Date | Location | Notes |
| 32 | Win | 32–0 | Sergey Kovalev | TKO | 8 (12), 2:29 | Jun 17, 2017 | Mandalay Bay Events Center, Paradise, Nevada, U.S. | Retained WBA (Super), IBF, and WBO light heavyweight titles;Won vacant The Ring light heavyweight title |
| 31 | Win | 31–0 | Sergey Kovalev | UD | 12 | Nov 19, 2016 | T-Mobile Arena, Paradise, Nevada, U.S. | Won WBA (Super), IBF, and WBO light heavyweight titles |
| 30 | Win | 30–0 | Alexander Brand | UD | 12 | Aug 6, 2016 | Oracle Arena, Oakland, California, U.S. | Won vacant WBO International light heavyweight title |
| 29 | Win | 29–0 | Sullivan Barrera | UD | 12 | Mar 26, 2016 | Oracle Arena, Oakland, California, U.S. | |
| 28 | Win | 28–0 | Paul Smith | TKO | 9 (12), 1:45 | Jun 20, 2015 | Oracle Arena, Oakland, California, U.S. | |
| 27 | Win | 27–0 | Edwin Rodríguez | UD | 12 | Nov 16, 2013 | Citizens Business Bank Arena, Ontario, California, U.S. | Retained WBA (Super) and The Ring super middleweight titles |
| 26 | Win | 26–0 | Chad Dawson | TKO | 10 (12), 2:45 | Sep 8, 2012 | Oracle Arena, Oakland, California, U.S. | Retained WBA (Super), WBC, and The Ring super middleweight titles |
| 25 | Win | 25–0 | Carl Froch | UD | 12 | Dec 17, 2011 | Boardwalk Hall, Atlantic City, New Jersey, U.S. | Retained WBA (Super) super middleweight title;Won WBC and vacant The Ring super middleweight titles;Super Six World Boxing Classic: final |
| 24 | Win | 24–0 | Arthur Abraham | UD | 12 | May 14, 2011 | Home Depot Center, Carson, California, U.S. | Retained WBA (Super) super middleweight title;Super Six World Boxing Classic: semi-final |
| 23 | Win | 23–0 | Sakio Bika | UD | 12 | Nov 27, 2010 | Oracle Arena, Oakland, California, U.S. | Retained WBA (Super) super middleweight title |
| 22 | Win | 22–0 | Allan Green | UD | 12 | Jun 19, 2010 | Oracle Arena, Oakland, California, U.S. | Retained WBA (Super) super middleweight title;Super Six World Boxing Classic: group stage 2 |
| 21 | Win | 21–0 | Mikkel Kessler | TD | 11 (12), 1:42 | Nov 21, 2009 | Oracle Arena, Oakland, California, U.S. | Won WBA (Super) super middleweight title;Super Six World Boxing Classic: group stage 1;Unanimous TD: Kessler cut from accidental head clashes |
| 20 | Win | 20–0 | Shelby Pudwill | TKO | 3 (10), 2:16 | Sep 12, 2009 | Pechanga Resort & Casino, Temecula, California, U.S. | |
| 19 | Win | 19–0 | Edison Miranda | UD | 12 | May 16, 2009 | Oracle Arena, Oakland, California, U.S. | Retained NABF and WBO–NABO super middleweight titles |
| 18 | Win | 18–0 | Henry Buchanan | UD | 12 | Feb 6, 2009 | Tachi Palace Hotel & Casino, Lemoore, California, U.S. | Won WBO–NABO super middleweight title;Won vacant NABF super middleweight title |
| 17 | Win | 17–0 | Esteban Camou | TKO | 3 (10), 2:46 | Dec 13, 2008 | Morongo Casino Resort & Spa, Cabazon, California, U.S. | |
| 16 | Win | 16–0 | Jerson Ravelo | TKO | 8 (12), 2:37 | Jun 20, 2008 | Royal Watler Cruise Terminal, George Town, Cayman Islands | Won vacant WBO–NABO super middleweight title |
| 15 | Win | 15–0 | Rubin Williams | TKO | 7 (10), 2:51 | Mar 20, 2008 | HP Pavilion, San Jose, California, U.S. | |
| 14 | Win | 14–0 | Roger Cantrell | TKO | 5 (10), 1:56 | Nov 16, 2007 | Beausejour Stadium, Gros Islet, Saint Lucia | |
| 13 | Win | 13–0 | Francisco Diaz | TKO | 3 (8), 2:59 | Jul 14, 2007 | Home Depot Center, Carson, California, U.S. | |
| 12 | Win | 12–0 | Dhafir Smith | TKO | 6 (8), 2:47 | May 17, 2007 | Tachi Palace Hotel & Casino, Lemoore, California, U.S. | |
| 11 | Win | 11–0 | Julio Jean | TKO | 3 (8), 2:04 | Mar 29, 2007 | HP Pavilion, San Jose, California, U.S. | |
| 10 | Win | 10–0 | Derrick Findley | UD | 6 | Nov 16, 2006 | HP Pavilion, San Jose, California, U.S. | |
| 9 | Win | 9–0 | Andy Kolle | RTD | 6 (8), 3:00 | Apr 29, 2006 | Foxwoods Resort Casino, Ledyard, Connecticut, U.S. | |
| 8 | Win | 8–0 | Kendall Gould | UD | 6 | Feb 23, 2006 | Tachi Palace Hotel & Casino, Lemoore, California, U.S. | |
| 7 | Win | 7–0 | Darnell Boone | UD | 6 | Nov 19, 2005 | Rose Garden, Portland, Oregon, U.S. | |
| 6 | Win | 6–0 | Glenn LaPlante | KO | 1 (6), 2:59 | Oct 1, 2005 | St. Pete Times Forum, Tampa, Florida, U.S. | |
| 5 | Win | 5–0 | Christopher Holt | RTD | 3 (6), 3:00 | Aug 18, 2005 | HP Pavilion, San Jose, California, U.S. | |
| 4 | Win | 4–0 | Ben Aragon | TKO | 3 (6), 0:59 | Jun 18, 2005 | FedExForum, Memphis, Tennessee, U.S. | |
| 3 | Win | 3–0 | Roy Ashworth | DQ | 3 (6), 2:56 | Apr 7, 2005 | Pechanga Resort & Casino, Temecula, California, U.S. | Ashworth disqualified for hitting on the break |
| 2 | Win | 2–0 | Kenny Kost | UD | 6 | Feb 10, 2005 | Palace Indian Gaming Center, Lemoore, California, U.S. | |
| 1 | Win | 1–0 | Chris Molina | TKO | 2 (4), 0:40 | Dec 18, 2004 | Staples Center, Los Angeles, California, U.S. | |