| Year | Title | Role | Notes |
| 1991 | Big Deals | Topaz Radulavitch | Television film |
| 1995–1996 | Exit 57 | Various | Main role; 12 episodesAlso creator and writer |
| 1999–2000 | Strangers with Candy | Geraldine Antonia "Jerri" Blank | Main role; 31 episodesAlso creator and writer |
| 2001 | Fling | The Receptionist | 2 episodes |
| Just Shoot Me! | Betsy Frayne |
| 2001–2015 | Late Show with David Letterman | Herself | 31 episodes |
| 2002–2003 | Sex and the City | Courtney Masterson | 4 episodes |
| Monk | Gail Fleming | 2 episodes |
| 2003 | Untitled New York Pilot | Connie | Unsold pilot |
| 2004 | Ed | Kate McCormick | 2 episodes |
| Cracking Up | Marla | Episode: "Prom Night" |
| The Wrong Coast | Various voices | Unknown episodes |
| Law & Order: Special Victims Unit | Charlie Donato | Episode: "Head" |
| 2005 | Wonder Showzen | Miss Amy | Episode: "History" |
| 2006 | Sesame Street | Snow White | Episode: "Snow White's Meltdown" |
| My Name Is Earl | Judy | Episode: "Larceny of a Kitty Kat" |
| 2006, 2014 | The Colbert Report | Klanswoman, Abraxxia (voice) | 2 episodes |
| 2007 | Andy Barker, P.I. | Rita Spaulding | Episode: "The Lady Varnishes" |
| Rescue Me | Beth | 2 episodes |
| 2008 | Yo Gabba Gabba! | Tooth Fairy | Episode: "Teeth" |
| Gym Teacher: The Movie | Principal Hoffman | Television film |
| 2009 | The Closer | Claire Howard | 2 episodes |
| The New Adventures of Old Christine | Frances "Frankenstein" Stein | Episode: "Old Christine Meets Young Frankenstein" |
| 2009–2023 | American Dad! | Roslyn Jenkins, Dr. Lizzy, Dr. Meg Penner (voice) | 4 episodes |
| 2010 | The Middle | Abby Michaels | Episode: "The Fun House" |
| The Problem Solverz | Thaz (voice) | Episode: "Neon Gnome" |
| Oddities | Herself | Episode: "Mummified Hand" |
| 2010–2012 | WordGirl | Miss Jade Davis, Rhyme, Various voices | 3 episodes |
| 2011 | Royal Pains | Nan | Episode: "Mulligian" |
| The Drunk and On Drugs Happy Fun Time Hour | Katherine "K-Money" Money | Main role; 6 episodes |
| Hot In Cleveland | Heather Shaw | 2 episodes |
| 2011–2014 | Raising Hope | Delilah | 3 episodes |
| 2011, 2019 | SpongeBob SquarePants | Ma Angler (voice) | 2 episodes |
| 2011–2025 | Bob's Burgers | Samantha (voice), Inga (voice) | 3 episodes |
| 2012 | The Good Wife | Stacie Hall | 3 episodes |
| Necessary Roughness | Dr. Jane Crosetti | Episode: "What's Eating You?" |
| 30 Rock | Visor Lady | Episode: "Unwindulax" |
| 2013 | F to 7th | Kate | Episode: "Family" |
| Doc McStuffins | Dress-Up Daisy (voice) | 2 episodes |
| Monsters vs. Aliens | Dr. Belle Cutter (voice) | Episode: "The Mystery of Dr. Cutter" |
| 2013–2014 | The Heart, She Holler | Hurshe Heartshe | Main role; 22 episodes |
| Alpha House | Louise Laffer | 14 episodes |
| 2014 | Lil Bub's Special Special | Herself | Television special |
| Mr. Pickles | Sally (voice) | Episode: "Dead Man's Curve" |
| Seriously Distracted | JD | 3 episodes |
| Dead Boss | Mary | Unsold pilot |
| 2014, 2019 | Broad City | Pam | 2 episodes |
| 2014–2020 | BoJack Horseman | Princess Carolyn, additional voices | Main role; 61 episodes |
| 2015 | Clarence | Ms. Donna-Joe Judley, Woman (voice) | Episode: "Hoofin' It" |
