| Organizations | Year | Category | Work | Result | Ref. |
| AACTA Awards | 2024 | Best Actress in a Series | Beef | Nominated | |
| Best Drama Series | Nominated |
| American Film Institute Awards | 2023 | Top 10 Television Programs of the Year | Won | |
| Annie Awards | 2020 | Outstanding Achievement for Voice Acting in an Animated Television/Broadcast Production | Tuca & Bertie | Nominated | |
| Astra TV Awards | 2024 | Best Streaming Limited or Anthology Series | Beef | Won | |
| Best Actress in a Streaming Limited or Anthology Series or Movie | Won |
| British Academy Television Awards | 2024 | Best International Programme | Nominated | |
| Critics' Choice Television Awards | 2024 | Best Limited Series | Won | |
| Best Actress in a Limited Series or Movie Made for Television | Won |
| 2025 | Best Comedy Special | Ali Wong: Single Lady | Won | |
| Directors Guild of America Awards | 2025 | Outstanding Directing – Variety Specials | Nominated | |
| Dorian Awards | 2023 | Best TV Performance – Comedy | Beef | Nominated | |
| Gold Derby Awards | 2023 | Limited/Movie Actress | Won | |
| Golden Globe Awards | 2024 | Best Limited or Anthology Series or Television Film | Won | |
| Best Actress – Miniseries or Television Film | Won |
| 2025 | Best Performance in Stand-Up Comedy on Television | Ali Wong: Single Lady | Won | |
| Goodreads Choice Awards | 2019 | Humor | Dear Girls | Won | |
| Gotham Awards | 2019 | Breakthrough Series – Short Form | Tuca & Bertie | Nominated | |
| 2023 | Beef | Won | |
| Outstanding Performance in a New Series | Won |
| Grammy Awards | 2026 | Best Comedy Album | Single Lady | Pending | |
| Independent Spirit Awards | 2024 | Best New Scripted Series | Beef | Won | |
| Best Lead Performance in a New Scripted Series | Won |
| Legionnaires of Laughter Legacy Awards | 2019 | Best Stand Up Comedian Female | — | Nominated | |
| NAACP Image Awards | 2024 | Outstanding Actress in a Television Movie, Mini-Series or Dramatic Special | Beef | Nominated | |
| Online Film & Television Association | 2023 | Best Actress in a Motion Picture, Limited or Anthology Series | Won | |
| People's Choice Awards | 2018 | Comedy Act | Herself | Nominated | |
| 2019 | Comedy Movie Star | Always Be My Maybe | Nominated | |
| 2021 | Comedy Act | The Milk & Money Tour | Nominated | |
| 2024 | Bingeworthy Show of the Year | Beef | Nominated | |
| Female TV Star of the Year | Nominated |
| Comedy TV Star of the Year | Nominated |
| Primetime Creative Arts Emmy Awards | 2024 | Outstanding Character Voice-Over Performance | Tuca & Bertie: Fledging Day | Nominated | |
| Primetime Emmy Awards | 2022 | Outstanding Writing for a Variety Special | Ali Wong: Don Wong | Nominated | |
| 2024 | Outstanding Limited or Anthology Series | Beef | Won | |
| Outstanding Lead Actress in a Limited or Anthology Series or Movie | Won |
| 2025 | Primetime Emmy Award for Outstanding Variety Special (Pre-Recorded) | Ali Wong: Single Lady | Nominated | |
| Producers Guild of America Awards | 2024 | Best Limited Series Television | Beef | Won | |
| 2025 | Outstanding Producer of Live Entertainment, Variety, Sketch, Standup & Talk Television | Ali Wong: Single Lady | Nominated | |
| Satellite Awards | 2024 | Best Miniseries or Television Film | Beef | Nominated | |
| Best Actress – Miniseries or Television Film | Nominated |
| Screen Actors Guild Awards | 2024 | Outstanding Performance by a Female Actor in a Miniseries or Television Movie | Won | |
| TCA Awards | 2023 | Outstanding Achievement in Movies, Miniseries and Specials | Won | |