| Res. | Record | Opponent | Method | Event | Date | Round | Time | Location | Notes |
| Loss | 16–5–1 | Natália Silva | Decision (unanimous) | UFC 315 | May 10, 2025 | 3 | 5:00 | Montreal, Quebec, Canada | |
| Loss | 16–4–1 | Valentina Shevchenko | Decision (unanimous) | UFC 306 | September 14, 2024 | 5 | 5:00 | Las Vegas, Nevada, United States | Lost the UFC Women's Flyweight Championship. |
| Draw | 16–3–1 | Valentina Shevchenko | Draw (split) | UFC Fight Night: Grasso vs. Shevchenko 2 | September 16, 2023 | 5 | 5:00 | Las Vegas, Nevada, United States | Retained the UFC Women's Flyweight Championship. |
| Win | 16–3 | Valentina Shevchenko | Submission (face crank) | UFC 285 | March 4, 2023 | 4 | 4:34 | Las Vegas, Nevada, United States | Won the UFC Women's Flyweight Championship. Performance of the Night. |
| Win | 15–3 | Viviane Araújo | Decision (unanimous) | UFC Fight Night: Grasso vs. Araújo | October 15, 2022 | 5 | 5:00 | Las Vegas, Nevada, United States | |
| Win | 14–3 | Joanne Wood | Submission (rear-naked choke) | UFC on ESPN: Blaydes vs. Daukaus | March 26, 2022 | 1 | 3:57 | Columbus, Ohio, United States | |
| Win | 13–3 | Maycee Barber | Decision (unanimous) | UFC 258 | February 13, 2021 | 3 | 5:00 | Las Vegas, Nevada, United States | |
| Win | 12–3 | Kim Ji-yeon | Decision (unanimous) | UFC Fight Night: Smith vs. Rakić | August 29, 2020 | 3 | 5:00 | Las Vegas, Nevada, United States | Flyweight debut. |
| Loss | 11–3 | Carla Esparza | Decision (majority) | UFC Fight Night: Rodríguez vs. Stephens | September 21, 2019 | 3 | 5:00 | Mexico City, Mexico | Fight of the Night. |
| Win | 11–2 | Karolina Kowalkiewicz | Decision (unanimous) | UFC 238 | June 8, 2019 | 3 | 5:00 | Chicago, Illinois, United States | |
| Loss | 10–2 | Tatiana Suarez | Submission (rear-naked choke) | UFC Fight Night: Maia vs. Usman | May 19, 2018 | 1 | 2:44 | Santiago, Chile | |
| Win | 10–1 | Randa Markos | Decision (split) | UFC Fight Night: Pettis vs. Moreno | August 5, 2017 | 3 | 5:00 | Mexico City, Mexico | Catchweight (119 lb) bout; Grasso missed weight. |
| Loss | 9–1 | Felice Herrig | Decision (unanimous) | UFC Fight Night: Bermudez vs. The Korean Zombie | February 4, 2017 | 3 | 5:00 | Houston, Texas, United States | |
| Win | 9–0 | Heather Jo Clark | Decision (unanimous) | The Ultimate Fighter Latin America 3 Finale: dos Anjos vs. Ferguson | November 5, 2016 | 3 | 5:00 | Mexico City, Mexico | |
| Win | 8–0 | Jodie Esquibel | Decision (unanimous) | Invicta FC 18 | July 29, 2016 | 3 | 5:00 | Kansas City, Missouri, United States | Performance of the Night. |
| Win | 7–0 | Mizuki Inoue | Decision (unanimous) | Invicta FC 11 | February 27, 2015 | 3 | 5:00 | Los Angeles, California, United States | Fight of the Night. |
| Win | 6–0 | Alida Gray | TKO (punches) | Invicta FC 10 | December 5, 2014 | 1 | 1:47 | Houston, Texas, United States | |
| Win | 5–0 | Ashley Cummins | Decision (unanimous) | Invicta FC 8 | September 6, 2014 | 3 | 5:00 | Kansas City, Missouri, United States | |
| Win | 4–0 | Karina Rodríguez | Decision (unanimous) | Xtreme Kombat 20 | August 31, 2013 | 3 | 5:00 | Izcalli, Mexico | |
| Win | 3–0 | Alejandra Alvarez | TKO (punches and knees) | Xtreme Kombat 20 | August 31, 2013 | 1 | 0:36 | Izcalli, Mexico | |
| Win | 2–0 | Lupita Hernandez | KO (punch) | Fight Hard Championship 3 | May 11, 2013 | 1 | 0:12 | Jalisco, Mexico | |
| Win | 1–0 | Sandra del Rincon | KO (punch) | GEX: Old Jack's Fight Night | December 19, 2012 | 1 | 0:15 | Jalisco, Mexico | Strawweight debut. |
