| No. | Image | Administrator | Tenure | Total days | President(s) served under |
| 1 | | Fowler Hamilton | September 30, 1961 – December 7, 1962 | 433 | John F. Kennedy, Lyndon B. Johnson |
| 2 | | David E. Bell | December 21, 1962 – July 31, 1966 | 1318 | Lyndon B. Johnson |
| 3 | | William Gaud | August 3, 1966 – January 10, 1969 | 892 | Lyndon B. Johnson |
| 4 | | John A. Hannah | April 2, 1969 – October 7, 1973 | 1650 | Richard Nixon |
| 5 | | Daniel Parker | October 31, 1973 – January 19, 1977 | 1177 | Richard Nixon, Gerald Ford |
| 6 | | John J. Gilligan | March 30, 1977 – March 31, 1979 | 732 | Jimmy Carter |
| 7 | | Douglas Bennet | August 3, 1979 – January 20, 1981 | 537 |
| 8 | | M. Peter McPherson | February 27, 1981 – August 7, 1987 | 2353 | Ronald Reagan |
| 9 | | M. Alan Woods | December 1, 1987 – June 29, 1989 | 577 | Ronald Reagan, George H. W. Bush |
| 10 | | Ronald Roskens | March 22, 1990 – December 1, 1992 | 986 | George H. W. Bush |
| 11 | | J. Brian Atwood | May 10, 1993 – June 30, 1999 | 2243 | Bill Clinton |
| 12 | | J. Brady Anderson | August 2, 1999 – January 20, 2001 | 528 |
| 13 | | Andrew Natsios | May 1, 2001 – January 14, 2006 | 1720 | George W. Bush |
| 14 | | Randall L. Tobias | March 31, 2006 – April 27, 2007 | 393 |
| 15 | | Henrietta H. Fore | November 14, 2007 – January 20, 2009 | 434 |
| – | | Alonzo Fulgham | January 20, 2009 – January 7, 2010 (acting) | 353 | Barack Obama |
| 16 | | Rajiv Shah | January 7, 2010 – February 19, 2015 | 1870 |
| – | | Alfonso E. Lenhardt | February 19, 2015 – December 2, 2015 (acting) | 287 |
| 17 | | Gayle Smith | December 2, 2015 – January 20, 2017 | 416 |
| – | | Wade Warren | January 20, 2017 – August 7, 2017 (acting) | 200 | Donald Trump |
| 18 | | Mark Green | August 7, 2017 – April 10, 2020 | 978 |
| – | | John Barsa | April 13, 2020 – November 6, 2020 (acting) | 208 |
| – | | Gloria Steele | January 20, 2021 – May 2, 2021 (acting) | 103 | Joe Biden |
| 19 | | Samantha Power | May 3, 2021 – January 20, 2025 | 1358 |
| – | | Jason Gray | January 20, 2025 – February 3, 2025 (acting) | 14 | Donald Trump |
| – | | Marco Rubio | February 3, 2025 – August 29, 2025 (acting) | 207 |
| – | | Russell Vought | August 29, 2025 – Present (acting) | 67 |