| Time | Name | Height | Weight | Position | College | Year | Draft | R |
| 4.21 | Xavier Worthy | 5 ft 11 in (1.80 m) | 165 lb (74.8 kg; 11.8 st) | Wide receiver | Texas | 2024 | No. 28 overall by Kansas City Chiefs | |
| 4.22 | John Ross | 5 ft 11 in (1.80 m) | 190 lb (86.2 kg; 13.6 st) | Wide receiver | Washington | 2017 | No. 9 overall by Cincinnati Bengals | |
| 4.23 | Kalon Barnes | 5 ft 11 in (1.80 m) | 183 lb (83.0 kg; 13.1 st) | Cornerback | Baylor | 2022 | No. 242 overall by Carolina Panthers | |
| 4.24 | Rondel Menendez | 5 ft 9 in (1.75 m) | 192 lb (87.1 kg; 13.7 st) | Wide receiver | Eastern Kentucky | 1999 | No. 247 overall by Atlanta Falcons | |
| Chris Johnson | 5 ft 11 in (1.80 m) | 192 lb (87.1 kg; 13.7 st) | Running back | East Carolina | 2008 | No. 24 overall by Tennessee Titans | |
| 4.26 | Jerome Mathis | 5 ft 11 in (1.80 m) | 184 lb (83.5 kg; 13.1 st) | Wide receiver | Hampton | 2005 | No. 114 overall by Houston Texans | |
| Dri Archer | 5 ft 8 in (1.73 m) | 173 lb (78.5 kg; 12.4 st) | Running back | Kent State | 2014 | No. 97 overall by Pittsburgh Steelers | |
| Tariq Woolen | 6 ft 4 in (1.93 m) | 205 lb (93.0 kg; 14.6 st) | Cornerback | UTSA | 2022 | No. 153 overall by Seattle Seahawks | |
| D. J. Turner | 5 ft 11 in (1.80 m) | 178 lb (80.7 kg; 12.7 st) | Cornerback | Michigan | 2023 | No. 60 overall by Cincinnati Bengals | |
| 4.27 | Henry Ruggs III | 6 ft 0 in (1.83 m) | 190 lb (86.2 kg; 13.6 st) | Wide receiver | Alabama | 2020 | No. 12 overall by Las Vegas Raiders | |
| Stanford Routt | 6 ft 2 in (1.88 m) | 193 lb (87.5 kg; 13.8 st) | Cornerback | Houston | 2005 | No. 38 overall by Oakland Raiders | |
| Marquise Goodwin | 5 ft 10 in (1.78 m) | 181 lb (82.1 kg; 12.9 st) | Wide receiver | Texas | 2013 | No. 78 overall by Buffalo Bills | |
| 4.28 | Champ Bailey | 6 ft 0 in (1.83 m) | 192 lb (87.1 kg; 13.7 st) | Cornerback | Georgia | 1999 | No. 7 overall by Washington Redskins | |
| Jacoby Ford | 5 ft 9 in (1.75 m) | 190 lb (86.2 kg; 13.6 st) | Wide receiver | Clemson | 2010 | No. 108 overall by Oakland Raiders | |
| Jalen Myrick | 5 ft 10 in (1.78 m) | 200 lb (90.7 kg; 14.3 st) | Cornerback | Minnesota | 2017 | No. 222 overall by Jacksonville Jaguars | |
| J. J. Nelson | 5 ft 10 in (1.78 m) | 156 lb (70.8 kg; 11.1 st) | Wide receiver | UAB | 2015 | No. 159 overall by Arizona Cardinals | |
| DeMarcus Van Dyke | 6 ft 1 in (1.85 m) | 187 lb (84.8 kg; 13.4 st) | Cornerback | Miami | 2011 | No. 81 overall by Oakland Raiders | |
| Tyquan Thornton | 6 ft 2 in (1.88 m) | 181 lb (82.1 kg; 12.9 st) | Wide receiver | Baylor | 2022 | No. 50 overall by New England Patriots |
| Nate Wiggins | 6 ft 1 in (1.85 m) | 173 lb (78.5 kg; 12.4 st) | Cornerback | Clemson | 2024 | No. 30 overall by Baltimore Ravens | |
| Maxwell Hairston | 6 ft 1 in (1.85 m) | 170 lb (77.1 kg; 12.1 st) | Cornerback | Kentucky | 2025 | No. 30 overall by Buffalo Bills |
| 4.29 | Fabian Washington | 5 ft 11 in (1.80 m) | 188 lb (85.3 kg; 13.4 st) | Cornerback | Nebraska | 2005 | No. 23 overall by Oakland Raiders | |
| Zedrick Woods | 5 ft 11 in (1.80 m) | 205 lb (93.0 kg; 14.6 st) | Safety | Mississippi | 2019 | Undrafted | |
| Javelin Guidry | 5 ft 9 in (1.75 m) | 191 lb (86.6 kg; 13.6 st) | Cornerback | Utah | 2020 | Undrafted | |
| Matthew Golden | 5 ft 11 in (1.80 m) | 191 lb (86.6 kg; 13.6 st) | Wide receiver | Texas | 2025 | No. 23 overall by Green Bay Packers |
| 4.30 | Darrent Williams | 5 ft 9 in (1.75 m) | 176 lb (79.8 kg; 12.6 st) | Cornerback | Oklahoma State | 2005 | No. 56 overall by Denver Broncos | |
| Tye Hill | 5 ft 10 in (1.78 m) | 185 lb (83.9 kg; 13.2 st) | Cornerback | Clemson | 2006 | No. 15 overall by St. Louis Rams | |
| Yamon Figurs | 5 ft 11 in (1.80 m) | 174 lb (78.9 kg; 12.4 st) | Wide receiver | Kansas State | 2007 | No. 74 overall by Baltimore Ravens | |
| Darrius Heyward-Bey | 6 ft 2 in (1.88 m) | 210 lb (95.3 kg; 15.0 st) | Wide receiver | Maryland | 2009 | No. 7 overall by Oakland Raiders | |
| Jamel Dean | 6 ft 1 in (1.85 m) | 206 lb (93.4 kg; 14.7 st) | Cornerback | Auburn | 2019 | No. 94 overall by Tampa Bay Buccaneers | |
| Jakorian Bennett | 5 ft 11 in (1.80 m) | 188 lb (85.3 kg; 13.4 st) | Cornerback | Maryland | 2023 | No. 104 overall by Las Vegas Raiders | |
| Darien Porter | 6 ft 3 in (1.91 m) | 195 lb (88.5 kg; 13.9 st) | Cornerback | Iowa State | 2025 | No. 68 overall by Las Vegas Raiders | |
| Dont'e Thornton Jr. | 6 ft 5 in (1.96 m) | 205 lb (93.0 kg; 14.6 st) | Wide receiver | Tennessee | 2025 | No. 108 overall by Las Vegas Raiders | |