| Constituency | Incumbent | Results | Candidates |
| State(linked tosummaries below) | PVI | Senator | Party | Electoral history | Last race |
| Alabama | R+15 | Tommy Tuberville | Republican | 2020 | 60.1% R | Incumbent retiringto run for governor | ▌Jared Hudson (Republican) ▌Dakarai Larriett (Democratic) ▌Steve Marshall (Republican) ▌Barry Moore (Republican) ▌Morgan Murphy (Republican) ▌Jeremy Spratling (Republican) ▌Kyle Sweetser (Democratic) ▌Rodney Walker (Republican) ▌Mark Wheeler II (Democratic) |
| Alaska | R+6 | Dan Sullivan | Republican | 20142020 | 53.9% R | Incumbent running | ▌Ann Diener (Democratic) ▌Dan Sullivan (Republican) |
| Arkansas | R+15 | Tom Cotton | Republican | 20142020 | 66.5% R | Incumbent running | ▌Micah Ashby (Republican) ▌Tom Cotton (Republican) ▌Ethan Dunbar (Democratic) ▌Jeb Little (Republican) ▌Hallie Shoffner (Democratic) |
| Colorado | D+6 | John Hickenlooper | Democratic | 2020 | 53.5% D | Incumbent running | ▌Karen Breslin (Democratic) ▌Julie Gonzales (Democratic) ▌John Hickenlooper (Democratic) ▌Janak Joshi (Republican) ▌George Markert (Republican) |
| Delaware | D+8 | Chris Coons | Democratic | 2010 (special)20142020 | 59.4% D | Incumbent running | ▌Christopher Beardsley (Democratic) ▌Chris Coons (Democratic) |
| Georgia | R+1 | Jon Ossoff | Democratic | 2021 | 50.6% D | Incumbent running | ▌Al Bartell (Independent) ▌Reagan Box (Republican) ▌Buddy Carter (Republican) ▌Mike Collins (Republican) ▌Derek Dooley (Republican) ▌Jon Ossoff (Democratic) |
| Idaho | R+18 | Jim Risch | Republican | 200820142020 | 62.6% R | Incumbent running | ▌Todd Achilles (Independent) ▌Jim Risch (Republican) ▌David Roth (Democratic) |
| Illinois | D+6 | Dick Durbin | Democratic | 19962002200820142020 | 54.9% D | Incumbent retiring | ▌Steve Botsford (Democratic) ▌Sean Brown (Democratic) ▌Awisi Bustos (Democratic) ▌R. Cary Capparelli (Republican) ▌Casey Chlebek (Republican) ▌CaSándra Claiborne (Republican) ▌Jonathan Dean (Democratic) ▌Adam Delgado (Democratic) ▌Jeannie Evans (Republican) ▌John Goodman (Republican) ▌Robin Kelly (Democratic) ▌Raja Krishnamoorthi (Democratic) ▌Pamela Denise Long (Republican) ▌Bryan Maxwell (Democratic) ▌Robert Palmer (Democratic) ▌Kevin Ryan (Democratic) ▌Jump Shepherd (Democratic) ▌Juliana Stratton (Democratic) ▌Christopher Swann (Democratic) ▌Jimmy Tillman (Republican) ▌Don Tracy (Republican) ▌Anthony Williams (Democratic) |
| Iowa | R+6 | Joni Ernst | Republican | 20142020 | 51.7% R | Incumbent retiring | ▌Jim Carlin (Republican) ▌Ashley Hinson (Republican) ▌Bob Krause (Democratic) ▌Thomas Laehn (Libertarian) ▌Nathan Sage (Democratic) ▌Richard Sherzan (Democratic) ▌Joshua Smith (Republican) ▌Josh Turek (Democratic) ▌Zach Wahls (Democratic) |
| Kansas | R+8 | Roger Marshall | Republican | 2020 | 53.2% R | Incumbent running | ▌Christy Davis (Democratic) ▌Roger Marshall (Republican) ▌Erik Murray (Democratic) ▌Anne Parelkar (Democratic) ▌Michael Soetaert (Democratic) ▌Sandy Spidel Neumann (Democratic) |
| Kentucky | R+15 | Mitch McConnell | Republican | 1984199019962002200820142020 | 57.8% R | Incumbent retiring | ▌Andy Barr (Republican) ▌Charles Booker (Democratic) ▌Daniel Cameron (Republican) ▌Michael Faris (Republican) ▌Logan Forsythe (Democratic) ▌Jonathan Holliday (Republican) ▌Jimmy Leon (Republican) ▌Amy McGrath (Democratic) ▌Nate Morris (Republican) ▌Dale Romans (Democratic) ▌Pamela Stevenson (Democratic) ▌Joel Willett (Democratic) |
| Louisiana | R+11 | Bill Cassidy | Republican | 20142020 | 59.3% R | Incumbent running | ▌Tracie Burke (Democratic) ▌Bill Cassidy (Republican) ▌Jamie Davis (Democratic) ▌Julie Emerson (Republican) ▌John Fleming (Republican) ▌Blake Miguez (Republican) ▌Kathy Seiden (Republican) ▌Eric Skrmetta (Republican) ▌Sammy Wyatt (Republican) |
| Maine | D+4 | Susan Collins | Republican | 19962002200820142020 | 51.0% R | Incumbent's intent unknown | ▌Natasha Alcala (Democratic) ▌Carmen Calabrese (Republican) ▌Bill Clarke (Republican) ▌David Costello (Democratic) ▌David Evans (Democratic) ▌Tucker Favreau (Democratic) ▌Janet Mills (Democratic) ▌Graham Platner (Democratic) ▌Phillip Rench (Independent) ▌Dan Smeriglio (Republican) |
| Massachusetts | D+14 | Ed Markey | Democratic | 2013 (special)20142020 | 66.2% D | Incumbent running | ▌John Deaton (Republican) ▌Ed Markey (Democratic) ▌Seth Moulton (Democratic) ▌Alex Rikleen (Democratic) |
| Michigan | EVEN | Gary Peters | Democratic | 20142020 | 49.9% D | Incumbent retiring | ▌Kent Benham (Republican) ▌Abdul El-Sayed (Democratic) ▌Fred Heurtebise (Republican) ▌Rachel Howard (Democratic) ▌Mallory McMorrow (Democratic) ▌Mike Rogers (Republican) ▌Bernadette Smith (Republican) ▌Haley Stevens (Democratic) |
| Minnesota | D+3 | Tina Smith | DFL | 2018 (appointed)2018 (special)2020 | DFL | Incumbent retiring | ▌Angie Craig (DFL) ▌Peggy Flanagan (DFL) ▌David Hann (Republican) ▌Adam Schwarze (Republican) ▌Tom Weiler (Republican) ▌Royce White (Republican) |
| Mississippi | R+11 | Cindy Hyde-Smith | Republican | 2018 (appointed)2018 (special)2020 | 54.1% R | Incumbent running | ▌Sarah Adlakha (Republican) ▌Scott Colom (Democratic) ▌Cindy Hyde-Smith (Republican) ▌Ty Pinkins (Independent) ▌Priscilla Williams-Till (Democratic) |
| Montana | R+10 | Steve Daines | Republican | 20142020 | 55.0% R | Incumbent running | ▌Alani Bankhead (Democratic) ▌Michael Black Wolf (Democratic) ▌Steve Daines (Republican) ▌Michael Hummert (Democratic) ▌Reilly Neill (Democratic) |
| Nebraska | R+10 | Pete Ricketts | Republican | 2023 (appointed)2024 (special) | 62.6% R | Incumbent running | ▌Dan Osborn (Independent) ▌Pete Ricketts (Republican) |
| New Hampshire | D+2 | Jeanne Shaheen | Democratic | 200820142020 | 56.6% D | Incumbent retiring | ▌Scott Brown (Republican) ▌Karishma Manzur (Democratic) ▌Chris Pappas (Democratic) ▌Jared Sullivan (Democratic) ▌John E. Sununu (Republican) |
| New Jersey | D+4 | Cory Booker | Democratic | 2013 (special)20142020 | 57.2% D | Incumbent running | ▌Cory Booker (Democratic) ▌Chris Fields (Democratic) |
| New Mexico | D+4 | Ben Ray Luján | Democratic | 2020 | 51.7% D | Incumbent running | ▌Ben Ray Luján (Democratic) |
| North Carolina | R+1 | Thom Tillis | Republican | 20142020 | 48.7% R | Incumbent retiring | ▌Shannon Bray (Libertarian) ▌Don Brown (Republican) ▌Robert Colon (Democratic) ▌Roy Cooper (Democratic) ▌Richard Dansie (Republican) ▌Justin Dues (Democratic) ▌Margot Dupre (Republican) ▌Daryl Farrow (Democratic) ▌Thomas "TJ" Johnson (Republican) ▌Michele Morrow (Republican) ▌Orrick Quick (Democratic) ▌Elizabeth Temple (Republican) ▌Michael Whatley (Republican) ▌Marcus Williams (Democratic) |
| Oklahoma | R+17 | Markwayne Mullin | Republican | 2022 (special) | 61.8% R | Incumbent running | ▌Troy Green (Democratic) ▌Markwayne Mullin (Republican) ▌N'Kiyla Thomas (Democratic) |
| Oregon | D+8 | Jeff Merkley | Democratic | 200820142020 | 56.9% D | Incumbent running | ▌Joe Johnson (Republican) ▌Jeff Merkley (Democratic) ▌Jake Ryan (Democratic) |
| Rhode Island | D+8 | Jack Reed | Democratic | 19962002200820142020 | 66.5% D | Incumbent running | ▌Connor Burbridge (Democratic) ▌Jack Reed (Democratic) |
| South Carolina | R+8 | Lindsey Graham | Republican | 2002200820142020 | 54.4% R | Incumbent running | ▌Annie Andrews (Democratic) ▌Brandon Brown (Democratic) ▌Catherine Fleming Bruce (Democratic) ▌Paul Dans (Republican) ▌Kyle Freeman (Democratic) ▌Lindsey Graham (Republican) ▌Mark Lynch (Republican) ▌Thomas Murphy (Republican) |
| South Dakota | R+15 | Mike Rounds | Republican | 20142020 | 65.7% R | Incumbent's intent unknown | ▌Julian Beaudion (Democratic) ▌Brian Bengs (Independent) ▌Justin McNeal (Republican) |
| Tennessee | R+14 | Bill Hagerty | Republican | 2020 | 62.2% R | Incumbent running | ▌Bill Hagerty (Republican) |
| Texas | R+6 | John Cornyn | Republican | 2002200820142020 | 53.5% R | Incumbent running | ▌John Adefope (Republican) ▌Anna Bender (Republican) ▌Virgil Bierschwale (Republican) ▌Sara Canady (Republican) ▌John Cornyn (Republican) ▌Jasmine Crockett (Democratic) ▌Ahmad Hassan (Democratic) ▌Wesley Hunt (Republican) ▌Gulrez Khan (Republican) ▌Ken Paxton (Republican) ▌James Talarico (Democratic) |
| Virginia | D+3 | Mark Warner | Democratic | 200820142020 | 56.0% D | Incumbent running | ▌Lorita Daniels (Democratic) ▌Kim Farrington (Republican) ▌Bryce Reeves (Republican) ▌Jason Reynolds (Democratic) ▌Mark Warner (Democratic) ▌David Williams (Republican) |
| West Virginia | R+21 | Shelley Moore Capito | Republican | 20142020 | 70.3% R | Incumbent running | ▌Shelley Moore Capito (Republican) ▌Alexander Gaaserud (Republican) ▌Zach Shrewsbury (Democratic) ▌Tom Willis (Republican) |
| Wyoming | R+23 | Cynthia Lummis | Republican | 2020 | 72.9% R | Incumbent retiring | ▌Jimmy Skovgard (Republican) |