| State | Incumbent | Candidates |
| Senator | Party | Electoral history | Result |
| Arizona | Kyrsten Sinema | Independent | 2018 | Incumbent retired.Democratic gain. | ▌Y Ruben Gallego (Democratic) 50.06% ▌Kari Lake (Republican) 47.65% ▌Eduardo Heredia-Quintana (Green) 2.29% |
| California | Laphonza Butler | Democratic | 2023 (appointed) | Interim appointee retired.Democratic hold.Winner also elected to finish the term; see above. | ▌Y Adam Schiff (Democratic) 58.87% ▌Steve Garvey (Republican) 41.13% |
| Connecticut | Chris Murphy | Democratic | 20122018 | Incumbent re-elected. | ▌Y Chris Murphy (Democratic) 58.58% ▌Matthew Corey (Republican) 39.78% ▌Robert F. Hyde (Independent) 0.9% ▌Justin Paglino (Green) 0.8% |
| Delaware | Tom Carper | Democratic | 2000200620122018 | Incumbent retired.Democratic hold. | ▌Y Lisa Blunt Rochester (Democratic) 56.6% ▌Eric Hansen (Republican) 39.5% ▌Michael Katz (Independent Party) 3.9% |
| Florida | Rick Scott | Republican | 2018 | Incumbent re-elected. | ▌Y Rick Scott (Republican) 55.57% ▌Debbie Mucarsel-Powell (Democratic) 42.79% ▌Ben Everidge (Independent) 0.6% ▌Feena Bonoan (Libertarian) 0.5% ▌Tuan Nguyen (Independent) 0.5% |
| Hawaii | Mazie Hirono | Democratic | 20122018 | Incumbent re-elected. | ▌Y Mazie Hirono (Democratic) 64.6% ▌Bob McDermott (Republican) 31.9% ▌Shelby Billionaire (We the People) 1.8% ▌Emma Pohlman (Green) 1.7% |
| Indiana | Mike Braun | Republican | 2018 | Incumbent retired to run for governor.Republican hold. | ▌Y Jim Banks (Republican) 58.64% ▌Valerie McCray (Democratic) 38.77% ▌Andy Horning (Libertarian) 2.59% |
| Maine | Angus King | Independent | 20122018 | Incumbent re-elected. | ▌Y Angus King (Independent) 52.06% ▌Demitroula Kouzounas (Republican) 34.64% ▌David Costello (Democratic) 10.83% ▌Jason Cherry (Independent) 2.5% |
| Maryland | Ben Cardin | Democratic | 200620122018 | Incumbent retired.Democratic hold. | ▌Y Angela Alsobrooks (Democratic) 54.64% ▌Larry Hogan (Republican) 42.84% ▌Mike Scott (Libertarian) 2.52% |
| Massachusetts | Elizabeth Warren | Democratic | 20122018 | Incumbent re-elected. | ▌Y Elizabeth Warren (Democratic) 59.81% ▌John Deaton (Republican) 40.00% |
| Michigan | Debbie Stabenow | Democratic | 2000200620122018 | Incumbent retired.Democratic hold. | ▌Y Elissa Slotkin (Democratic) 48.64% ▌Mike Rogers (Republican) 48.30% ▌Joseph Solis-Mullen (Libertarian) 1.0% ▌Douglas Marsh (Green) 1.0% ▌Dave Stein (Constitution) 0.7% ▌Doug Dern (Natural Law) 0.3% |
| Minnesota | Amy Klobuchar | DFL | 200620122018 | Incumbent re-elected. | ▌Y Amy Klobuchar (DFL) 56.20% ▌Royce White (Republican) 40.5% ▌Rebecca Whiting (Libertarian) 1.7% ▌Joyce Lacey (Independence) 1.5% |
| Mississippi | Roger Wicker | Republican | 2007 (appointed)2008 (special)20122018 | Incumbent re-elected. | ▌Y Roger Wicker (Republican) 62.81% ▌Ty Pinkins (Democratic) 36.6% |
| Missouri | Josh Hawley | Republican | 2018 | Incumbent re-elected. | ▌Y Josh Hawley (Republican) 55.58% ▌Lucas Kunce (Democratic) 41.76% ▌W. C. Young (Libertarian) 1.2% ▌Jared Young (Independent) 0.7% ▌Nathan Kline (Green) 0.7% |
| Montana | Jon Tester | Democratic | 200620122018 | Incumbent lost re-election.Republican gain. | ▌Y Tim Sheehy (Republican) 52.64% ▌Jon Tester (Democratic) 45.50% ▌Sid Daoud (Libertarian) 1.2% ▌Michael Downey (Green) 0.7% |
| Nebraska | Deb Fischer | Republican | 20122018 | Incumbent re-elected. | ▌Y Deb Fischer (Republican) 53.19% ▌Dan Osborn (Independent) 46.47% |
| Nevada | Jacky Rosen | Democratic | 2018 | Incumbent re-elected. | ▌Y Jacky Rosen (Democratic) 47.87% ▌Sam Brown (Republican) 46.20% ▌None of These Candidates 3.0% ▌Janine Hansen (Independent American) 1.5% ▌Christopher Cunningham (Libertarian) 1.4% |
| New Jersey | George Helmy | Democratic | 2024 (appointed) | Interim appointee retired.Democratic hold.Interim appointee resigned December 8, 2024, to give Kim preferential seniority.Winner appointed the same day. | ▌Y Andy Kim (Democratic) 53.64% ▌Curtis Bashaw (Republican) 44.00% ▌Christina Khalil (Green) 1.1% ▌Ken Kaplan (Libertarian) 0.6% ▌Patricia Mooneyham (Independent) 0.4% ▌Joanne Kuniansky (Socialist Workers) 0.2% |
| New Mexico | Martin Heinrich | Democratic | 20122018 | Incumbent re-elected. | ▌Y Martin Heinrich (Democratic) 55.06% ▌Nella Domenici (Republican) 44.9% |
| New York | Kirsten Gillibrand | Democratic | 2009 (appointed)2010 (special)20122018 | Incumbent re-elected. | ▌Y Kirsten Gillibrand (Democratic) 58.5% ▌Mike Sapraicone (Republican) 41.0% ▌Diane Sare (LaRouche) 0.5% |
| North Dakota | Kevin Cramer | Republican | 2018 | Incumbent re-elected. | ▌Y Kevin Cramer (Republican) 66.5% ▌Katrina Christiansen (Democratic–NPL) 33.5% |
| Ohio | Sherrod Brown | Democratic | 200620122018 | Incumbent lost re-election.Republican gain. | ▌Y Bernie Moreno (Republican) 50.09% ▌Sherrod Brown (Democratic) 46.47% ▌Don Kissick (Libertarian) 3.44% |
| Pennsylvania | Bob Casey Jr. | Democratic | 200620122018 | Incumbent lost re-election.Republican gain. | ▌Y Dave McCormick (Republican) 48.82% ▌Bob Casey Jr. (Democratic) 48.60% ▌John Thomas (Libertarian) 1.24% ▌Leila Hazou (Green) 1.00% ▌Marty Selker (Constitution) 0.3% |
| Rhode Island | Sheldon Whitehouse | Democratic | 200620122018 | Incumbent re-elected. | ▌Y Sheldon Whitehouse (Democratic) 59.90% ▌Patricia Morgan (Republican) 40.10% |
| Tennessee | Marsha Blackburn | Republican | 2018 | Incumbent re-elected. | ▌Y Marsha Blackburn (Republican) 63.8% ▌Gloria Johnson (Democratic) 34.2% ▌Tharon Chandler (Independent) 0.9% ▌Pamela Moses (Independent) 0.8% ▌Hastina Robinson (Independent) 0.3% |
| Texas | Ted Cruz | Republican | 20122018 | Incumbent re-elected. | ▌Y Ted Cruz (Republican) 53.07% ▌Colin Allred (Democratic) 44.57% ▌Ted Brown (Libertarian) 2.36% |
| Utah | Mitt Romney | Republican | 2018 | Incumbent retired.Republican hold. | ▌Y John Curtis (Republican) 62.50% ▌Caroline Gleich (Democratic) 31.74% ▌Carlton Bowen (Independent American) 5.74% |
| Vermont | Bernie Sanders | Independent | 200620122018 | Incumbent re-elected. | ▌Y Bernie Sanders (Independent) 63.16% ▌Gerald Malloy (Republican) 32.07% ▌Steve Berry (Independent) 2.2% ▌Matt Hill (Libertarian) 1.2% ▌Justin Schoville (Peace and Justice) 0.9% ▌Matt Stewart Greenstein (Independent) 0.3% |
| Virginia | Tim Kaine | Democratic | 20122018 | Incumbent re-elected. | ▌Y Tim Kaine (Democratic) 54.4% ▌Hung Cao (Republican) 45.4% |
| Washington | Maria Cantwell | Democratic | 2000200620122018 | Incumbent re-elected. | ▌Y Maria Cantwell (Democratic) 59.09% ▌Raul Garcia (Republican) 40.64% |
| West Virginia | Joe Manchin | Independent | 2010 (special)20122018 | Incumbent retired.Republican gain. Winner delayed start of term until January 13, 2025, to finish his term as Governor of West Virginia. | ▌Y Jim Justice (Republican) 68.75% ▌Glenn Elliott (Democratic) 27.26% ▌David Moran (Libertarian) 3.99% |
| Wisconsin | Tammy Baldwin | Democratic | 20122018 | Incumbent re-elected. | ▌Y Tammy Baldwin (Democratic) 49.33% ▌Eric Hovde (Republican) 48.48% ▌Phil Anderson (Disrupt the Corruption) 1.2% ▌Thomas Leager (America First) 0.9% |
| Wyoming | John Barrasso | Republican | 2007 (appointed)2008 (special)20122018 | Incumbent re-elected. | ▌Y John Barrasso (Republican) 75.11% ▌Scott Morrow (Democratic) 24.12% |